Patents by Inventor Lincoln C. Young
Lincoln C. Young has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8715446Abstract: A latent solvent-based microfluidic apparatus and method involves laminate bonding of two non-elastomeric, cyclic olefin copolymer (COC) components having opposing surfaces to be bonded, wherein in a contacted state there is at least one interstitial space between the contacted surfaces, applying an organic latent solvent to at least one of the opposing surfaces, wherein the latent solvent is in an inactive state, contacting the two opposing surfaces together, actively removing the latent solvent from the at least one interstitial space; and adjusting a latent solvency parameter to activate the latent solvent, wherein the opposing contacted surfaces become bonded.Type: GrantFiled: January 20, 2011Date of Patent: May 6, 2014Assignee: Rheonix, Inc.Inventors: Todd Roswech, Peng Zhou, Lincoln C. Young
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Patent number: 8715447Abstract: A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation.Type: GrantFiled: July 19, 2011Date of Patent: May 6, 2014Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Publication number: 20140093431Abstract: The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.Type: ApplicationFiled: December 11, 2013Publication date: April 3, 2014Applicant: RHEONIX, INC.Inventors: PENG ZHOU, LINCOLN C. YOUNG
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Publication number: 20140073517Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.Type: ApplicationFiled: March 15, 2013Publication date: March 13, 2014Applicant: RHEONIX, INC.Inventors: Peng Zhou, Lincoln C. Young, Benjamin Thomas, Zongyuan Chen, Todd Roswech, Gwendolyn Spizz, Rubina Yasmin
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Publication number: 20140065598Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.Type: ApplicationFiled: February 19, 2013Publication date: March 6, 2014Inventors: Peng Zhou, Lincoln C. Young, Benjamin Thomas, Zongyuan Chen, Greg Mouchka, Todd Roswech, Gwendolyn Spizz, Rubina Yasmin
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Patent number: 8647337Abstract: A dispensing head for dispensing a cryogenic fluid may comprise a flow passage configured to be placed in flow communication with a reservoir containing a cryogenic fluid, the flow passage defining a flow passage inlet opening configured to receive the cryogenic fluid from the reservoir, and a flow passage outlet opening opposite the flow passage inlet opening. The dispensing head may further comprise a dispensing member configured to dispense the cryogenic fluid, the dispensing member defining a lumen having a lumen inlet opening and a lumen outlet opening; and at least one porous member disposed in the flow passage, the at least one porous member being configured as a primary flow regulation mechanism to limit a flow rate of the cryogenic fluid as it flows from the reservoir to the lumen outlet opening.Type: GrantFiled: June 23, 2009Date of Patent: February 11, 2014Assignee: STC Consulting, LLCInventors: R. Sam Niedbala, Lincoln C. Young, Peng Zhou
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Patent number: 8646482Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.Type: GrantFiled: August 12, 2010Date of Patent: February 11, 2014Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Patent number: 8609039Abstract: The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.Type: GrantFiled: December 20, 2011Date of Patent: December 17, 2013Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Patent number: 8535020Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.Type: GrantFiled: October 9, 2008Date of Patent: September 17, 2013Assignee: Rheonix, Inc.Inventors: Lincoln C. Young, Peng Zhou
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Patent number: 8512502Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.Type: GrantFiled: July 23, 2012Date of Patent: August 20, 2013Assignee: Rheonix, Inc.Inventors: Lincoln C. Young, Peng Zhou
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Patent number: 8383039Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.Type: GrantFiled: February 23, 2011Date of Patent: February 26, 2013Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young, Benjamin Thomas, Zongyuan Chen, Greg Mouchka, Todd Roswech, Gwendolyn Spizz, Rubina Yasmin
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Patent number: 8372355Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.Type: GrantFiled: May 19, 2011Date of Patent: February 12, 2013Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Patent number: 8323586Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.Type: GrantFiled: July 25, 2011Date of Patent: December 4, 2012Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Publication number: 20120279638Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.Type: ApplicationFiled: July 23, 2012Publication date: November 8, 2012Applicant: RHEONIX, INC.Inventors: Peng Zhou, Lincoln C. Young
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Patent number: 8293053Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.Type: GrantFiled: October 9, 2008Date of Patent: October 23, 2012Assignee: Rheonix, Inc.Inventors: Lincoln C. Young, Peng Zhou
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Publication number: 20120214168Abstract: A method is provided for purifying nucleic acid from a sample in a microfluidic device. The method can be used to purify nucleic acids from any source known in the art that comprises nucleic acids, such as prokaryotic or eukaryotic organisms, viruses, cell, tissues, organs, etc. In a specific example, the tissue is whole blood. The method for purifying nucleic acid may run fully automated in the microfluidic device.Type: ApplicationFiled: February 21, 2012Publication date: August 23, 2012Applicant: RHEONIX, INC.Inventors: Lincoln C. Young, Peng Zhou, Gwendolyn Spizz, Rubina Yasmin
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Publication number: 20120128549Abstract: The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.Type: ApplicationFiled: December 20, 2011Publication date: May 24, 2012Applicant: RHEONIX, INC.Inventors: Peng Zhou, Lincoln C. Young
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Publication number: 20120115738Abstract: A microfluidic device for analyzing a sample of interest is provided. The microfluidic device can comprise a microfluidic device body, wherein the microfluidic device body comprises a sample preparation area, a nucleic acid amplification area, a nucleic acid analysis area, and a network of fluid channels. Each of the sample preparation area, the nucleic acid amplification area and the nucleic acid analysis area are fluidly interconnected to at least one of the other two areas by at least one of the fluid channels. Using the microfluidic device, sample preparation can be combined with amplification of a biologically active molecule, and a suitable biological sample can be provided for analysis and/or detection of a molecule of interest. The small-scale apparatus and methods provided are easier, faster, less expensive, and equally efficacious compared to larger scale equipment for the preparation and analysis of a biological sample.Type: ApplicationFiled: October 10, 2008Publication date: May 10, 2012Inventors: Peng Zhou, Lincoln C. Young, Todd Roswech, Gwendolyn Spizz, Zongyuan Chen, Benjamin W. Thomas, Travis Lee
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Patent number: 8101428Abstract: The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.Type: GrantFiled: June 3, 2011Date of Patent: January 24, 2012Assignee: Rheonix, Inc.Inventors: Peng Zhou, Lincoln C. Young
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Patent number: D681807Type: GrantFiled: December 21, 2010Date of Patent: May 7, 2013Assignee: Cryoconcepts LPInventors: R. Sam Niedbala, Lincoln C. Young, Peng Zhou, Matthew Sommerfield, Jarrett Seng