Abstract: Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Terminal devices and methods for designing a network application product are provided. The terminal device includes a task starting interface, a graphical displaying interface, an inputting interface. The task starting interface is configured to receive a task starting instruction to obtain a plurality of first type e-cards having at least one dimensionality type. Each first type e-card contains graphic information corresponding to a dimensionality type and text information corresponding to the graphic information. The graphical displaying interface is configured to display the plurality of first type e-cards. The inputting interface is configured to receive an inputting instruction to select at least two first type e-cards from the plurality of first type e-cards. The inputting interface is further configured to receive context information generated by correlating information including the graphic information and the text information on the at least two first type e-cards.

Abstract: The present invention is applicable to the field of Internet, and provides an interactive method and apparatus based on a web picture. The method includes: obtaining a web picture including a human image; determining a region where a specific part of the human image in the web picture is located; receiving an interactive instruction in the region where the specific part is located, and generating the interactive information corresponding to the specific part. When receiving the interactive instruction in the region where the specific part is located, generating the interactive information corresponding to the specific part by determining the region where the specific part of the human image in the obtained web picture including the human image is located. The interactive method provided by the embodiment of the present invention is simple to operate, and the interactive manners are various.

Abstract: The embodiments of the present disclosure disclose a gate driving circuit and a display panel. In the gate driving circuit, a control unit of a shift register may input a dual pulse control signal to a first control terminal of an output unit; and the output unit outputs a scanning signal having a pulse width equal to a pulse period of the dual pulse control signal to a corresponding gate line under the control of the dual pulse control signal. In this way, the output unit is controlled by the control unit to output a scanning signal of which a pulse width may be modulated, so as to output a gate signal of which a pulse width may be modulated.

Abstract: This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human inteferon like alpha 2b (HuIFN-?2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon, therapy, such as viral diseases and cancer.

Abstract: Provided herein are KRAS G12C inhibitors, compounds of formula (II), or a pharmaceutically acceptable salt thereof: compositions of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Disclosed is a disposable absorbent article having an outer shell and a detachable disposable absorbent core insert supported on an inside surface of the outer shell. The core insert is attached to the inside surface and is detachable therefrom. The inside surface further includes a retaining structure for receiving the absorbent core insert, the core insert being attachable with the retaining structure and detachable from the retaining structure.

Abstract: Disclosed are a method and apparatus for demodulating a signal. The method comprises: obtaining a received signal, wherein the received signal comprises a phase noise signal; establishing a likelihood probability ratio integral model on the basis of the received signal and a preset phase noise parameter, wherein the phase noise parameter represents the phase noise signal and is a random variable; performing phase rotation angle extraction and transformation processing and discretization processing on the likelihood probability ratio integral model to obtain a likelihood probability ratio discrete model, wherein the phase rotation angle represents the phase rotation angle obtained on the basis of the phase noise signal; and determining a likelihood probability ratio corresponding to the received signal on the basis of the likelihood probability ratio discrete model to obtain a demodulation result.

Abstract: A planting implement including a toolbar and a seed metering system supported by the toolbar. The seed metering system includes at least one row unit. Each row unit includes a frame, an auxiliary seed hopper supported by the frame, a seed meter fluidly coupled to the auxiliary seed hopper, and a vacuum fan fluidly coupled to the auxiliary seed hopper and the seed meter in a closed fluid system in which the vacuum fan recirculates air through the auxiliary seed hopper and the seed meter.

Abstract: Disclosed are a method and apparatus for demodulating a signal. The method comprises: obtaining a received signal, wherein the received signal comprises a phase noise signal; establishing a likelihood probability ratio integral model on the basis of the received signal and a preset phase noise parameter, wherein the phase noise parameter represents the phase noise signal and is a random variable; performing phase rotation angle extraction and transformation processing and discretization processing on the likelihood probability ratio integral model to obtain a likelihood probability ratio discrete model, wherein the phase rotation angle represents the phase rotation angle obtained on the basis of the phase noise signal; and determining a likelihood probability ratio corresponding to the received signal on the basis of the likelihood probability ratio discrete model to obtain a demodulation result.

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KNO35 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: This disclosure is directed to methods, compounds and compositions for delivering nucleic acids to a cell of interest. In particular, it provides salts that are particularly effective in delivering nucleic acids to cells in the lung for disorders such as cystic fibrosis (CF).

Abstract: A test substrate includes a base and a first electrode layer, a pixel defining layer, a light-emitting functional layer and a second electrode layer disposed on the base in sequence. The test substrate has at least two test regions, and each test region is a region where one first electrode of the plurality of first electrodes is located. Each test region includes a first region. Orthographic projections of portions of the pixel defining layer and the light-emitting functional layer located in a same first region on the base overlap with each other, and areas of orthographic projections of portions of the first electrode layer located in first regions of the at least two test regions are different.

Abstract: A transistor with dual spacers includes a gate, a first dual spacer and a second inner spacer. The gate is disposed on a substrate, wherein the gate includes a gate dielectric layer and a gate electrode, and the gate dielectric layer protrudes from the gate electrode and covers the substrate. The first dual spacer is disposed on the gate dielectric layer beside the gate, wherein the first dual spacer includes a first inner spacer and a first outer spacer. The second inner spacer having an L-shaped profile is disposed on the gate dielectric layer beside the first dual spacer. The present invention also provides a method of forming said transistor with dual spacers.

Abstract: A transistor with dual spacers includes a gate, a first dual spacer and a second inner spacer. The gate is disposed on a substrate, wherein the gate includes a gate dielectric layer and a gate electrode, and the gate dielectric layer protrudes from the gate electrode and covers the substrate. The first dual spacer is disposed on the gate dielectric layer beside the gate, wherein the first dual spacer includes a first inner spacer and a first outer spacer. The second inner spacer having an L-shaped profile is disposed on the gate dielectric layer beside the first dual spacer. The present invention also provides a method of forming said transistor with dual spacers.

Abstract: A system may include an array of storage devices configured to store a data. The system may further include an array of processing nodes in communication with the array of storage devices. The array of processing nodes may receive a request to perform at least one task associated with the data. The request may include a function call to a function configured to operate on a first data table and a second data table included in the data. The array of processing nodes may partition the first data table among respective subsets of the processing nodes based on a partition key. The array of processing nodes may distribute the second data table among the partitions based on the partition key. The array of processing nodes may execute the function on the first data table and the second data table at each of the partitions. A method and computer-readable medium may also be implemented.

Abstract: A method for compensating the pixel driving circuit may include: in a light emitting phase of the pixel driving circuit, sensing an electric signal of the first electrode of the electroluminescent element, and calculating an electrical compensation signal based on the electric signal; in the light emitting phase of the pixel driving circuit, sensing a brightness signal of the electroluminescent element by a photosensitive sensor and calculating an optical compensation signal according to the brightness signal; and generating a comprehensive compensation signal according to the electrical compensation signal and the optical compensation signal, and controlling a signal on a control terminal of the drive transistor according to the comprehensive compensation signal.