Abstract: The invention relates to various polymorphic forms and amorphous form of sodium 4-((3-(4-cyclohexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzate, including the polymorphic form A, mixtures of the polymorphs, process for the preparation thereof and the use thereof in a pharmaceutical composition containing thereof.

Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R1 represents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or -alkylaryl; R2 represents H; or alkyl; R3 represents H; or alkyl; U, V and W represent —(CH2)—; or U and V together represent —CH?CH— and W represents C?O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C1-6haloalkoxy and halo); or optionally substituted heterocyclyl (wherein opti

Abstract: This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology in described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon like alpha 2b (HuIFN-?2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.

Abstract: Disclosed are an aza-phenalene-3-ketone derivative, a preparation method thereof and its application as a PARP inhibitor. The aza-phenalene-3-ketone derivative has the following structure: wherein R is hydrogen, methyl, ethyl, isopropyl, benzyl or 3-methyl-3-butenyl. The aza-phenalene-3-ketone derivative has very high activity for inhibiting PARP, thereby providing a good basis for new drug research of developing a nitrogen-doped phenalene-3-ketone compound as PARP inhibitor to treat cancer.

Abstract: An integrated circuit operable in a scan mode includes a scan chain formed by cascaded flip-flop cells. Each flip-flop cell includes a master latch that receives a first data signal and generates a first latch signal, a slave latch that receives the first latch signal and generates a second latch signal, and a multiplexer having first and second inputs respectively connected to the master and slave latches for receiving a first input signal and the second latch signal, and generating a scan data output signal depending on a trig signal. The first input signal is one of the first data signal and the first latch signal. The clock signal provided to the slave latch is gated by the trig signal.

Abstract: An integrated circuit receives test-control information that is phase encoded on a scan clock used for testing a scan chain within the IC. The phase encoding does not affect the normal use of the scan clock and scan test chain and allows additional test-related data such as power supply, clock, and additional global and specialized status data to be collected by a secondary test data storage system such as a shift register. The phase encoding further controls selectively outputting the enhanced test status or the traditional scan test outputs.

Abstract: The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.

Abstract: The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF recptor TrkA.

Abstract: Embodiments of the present disclosure provide techniques and configurations for an apparatus for stress event detection. In some embodiments, the apparatus may be a wearable device and may include at least one first sensor disposed on the wearable apparatus to generate a first sensor signal indicative of a brain activity of a user, at least one second sensor disposed on the wearable apparatus to generate a second sensor signal indicative of a heart rate of the user, and at least one third sensor disposed on the wearable apparatus to generate a third sensor signal indicative of a respiration rate of the user. The apparatus may further include a controller coupled with the at least first, second, and third sensors, to detect a stress event for the user, based at least in part on the first, second, and third sensor signals. Other embodiments may be described and/or claimed.

Abstract: The invention relates to various polymorphic forms and amorphous form of sodium 4-((3-(4-cyclo-hexylpiperazin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzate, including the polymorphic form A, mixtures of the polymorphs, process for the preparation thereof and the use thereof in a pharmaceutical composition containing thereof.

Abstract: An integrated circuit operable in a scan mode includes a scan chain formed by cascaded flip-flop cells. Each flip-flop cell includes a master latch that receives a first data signal and generates a first latch signal, a slave latch that receives the first latch signal and generates a second latch signal, and a multiplexer having first and second inputs respectively connected to the master and slave latches that receives a first input signal and the second latch signal, and generates a scan data output signal depending on an input trigger signal. The first input signal is one of the first data signal and the first latch signal. The clock signal provided to the slave latch is gated by the input trigger signal.

Abstract: Disclosed in embodiments of the present invention are an MCS index determination method and base station equipment. The method comprises: calculating, by a base station equipment and according to a first SINR obtained by measuring an SRS signal at time k0, a second SINR of a PUSCH signal; determining, by the base station equipment and according to the second SINR, a first MCS index; and calculating, by the base station equipment and according to the first MCS index and data volume actually required to be transmitted by a user, an actually scheduled PRB amount, and a second MCS index actually used.

Abstract: It is provided a method performed at a terminal for information interaction including the following steps: detecting current position and direction information of the terminal when the terminal shoots a scene image; determining an information search range of the terminal according to an image capture ability of the terminal; sending the current position and direction information and the information search range of the terminal to a server, wherein the server is configured to return, among a plurality of social information items published by one or more terminals on a social network platform, an information collection within the information search range and satisfying the position and direction information of the terminal; obtaining the scene image using the terminal; and displaying the information collection returned by the server along with the scene image.

Abstract: Methods for processing whole blood samples are provided. Aspects of the methods include depleting leukocytes from a whole blood sample to produce a leukocyte depleted sample, and then lysing red blood cells (RBCs) in the resultant leukocyte depleted sample to produce a leukocyte/RBC depleted sample. Also provided are compositions and kits for practicing embodiments of the invention. The methods and compositions find use in a variety of different applications, including the detection of circulating tumor cells (CTCs).

Abstract: Present disclosure relates to a method for providing graphical panel of a docking device and the docking device thereof. The method includes following steps: electrically coupling the docking device having ports to a first device having a display, wherein some indicators corresponding to the ports are provided on the docking device; and providing a graphical panel having a first contour corresponding to a second contour of the docking device, wherein some virtual indicators are positioned on the graphical panel corresponding to the visual indicators.

Abstract: The present disclosure herein provides a compound prescription colloidal eyedrop gel. The compound prescription colloidal eyedrop gel includes a plurality of carboxymethyl-hexanoyl chitosan (CHC) micelles, a basic structural stabilizer connecting the plurality of CHC micelles, a first drug inside the CHC micelle, and a second drug outside the CHC micelle.

Abstract: Present disclosure relates to a method for managing a docking device and the docking device thereof. The docking device is configured with a processor and at least two coupling ports. The method comprises following steps: electrically coupling a computer and/or at least one peripheral device to the at least two coupling ports respectively; retrieving a plurality of characteristic profiles by the processor, wherein each of the characteristic profiles is retrieved from each of the at least two coupling ports; receiving, by the processor, an input signal from the computer or the at least one peripheral device; and changing the characteristic profiles based on the input signal by the processor.

Abstract: The method includes: a) connecting a dock between a laptop and a power adapter; b) checking whether a smartphone is connected to the dock; c) verifying whether AC power can supply power over a required value of the laptop if yes in step b); d) verifying whether a residual battery capacity of the laptop is greater than 80% if yes in step c); e) verifying whether another smartphone is connected to the dock if yes in step d); f) verifying whether to enable data transfer if yes in step e); g) activating a CDP mode if yes in step f); h) activating a DCP mode if no in step f); i) verifying whether to enable faster charging if no in step e); j) going back to step f) if yes in step i); k) activating an SDP mode if no in step i); and l) showing a warning if no in steps b), c) or d).

Abstract: A screw holding and dispensing device includes a casing, a number of elastic members latched on an inner sidewall of the casing, and a pressing member received by the elastic member. Each elastic member carries a screw, to release a screw, an external force is applied on the pressing member, the pressing member is driven to move out of the top elastic member, the pressing member moves down and drives out the lowermost screw from the bottom elastic member, and the screw slides into a corresponding screw hole.

Abstract: A tunnel magnetoresistance (TMR) read sensor having a tabbed AFM layer and an extended pinned layer and methods for making the same are provided. The TMR read sensor has an AFM layer recessed from the air bearing surface, providing a reduced shield-to-shield distance.