Abstract: The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HV protease, the inhibition of HV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: There is provided herein a low foam surfactant composition comprising: (a) di-trisiloxane alkoxylate component of the general formula (I): (R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2??(I); and, (b) mono-trisiloxane alkoxylate component of the general formula (II): (R12R13R14SiO)2Si(R15)R16??(II) wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate and methods of making the same.

Abstract: The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: The present invention is directed to 2,5,6-substituted morpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Methods and systems for discovery of a set of nodes in a network. The method comprises selecting a node amongst nodes in a group of nodes to be processed; and instructing to implement a discovery procedure for the selected node. The procedure comprises broadcasting a neighbor discovery request from a node currently selected on a shared transmission medium of the network; and receiving at the node currently selected replies sent by neighbor nodes on the shared transmission medium and adding the neighbor nodes to the group of nodes to be processed; and repeating the steps of selecting and instructing for other nodes in the group of nodes to be processed, until all nodes of the set are discovered.

Abstract: The present invention is directed to 5-heteroarylmorpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Methods and systems for discovery of a set of nodes (20, 30) in a network (165). The method comprises selecting (S11) a node (20) amongst nodes in a group of nodes to be processed; and instructing (S12) to implement a discovery procedure for the selected node. The procedure comprises broadcasting (S22) a neighbor discovery request from a node (20) currently selected on a shared transmission medium (1) of the network; and receiving (S23) at the node (20) currently selected replies sent (S34) by neighbor nodes on the shared transmission medium and adding (S13) the neighbor nodes to the group of nodes to be processed; and repeating (S14) the steps of selecting and instructing for other nodes (30) in the group of nodes to be processed, until all nodes of the set are discovered.

Abstract: The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or racemic mixture or stereoisomer thereof, and methods for preventing or treating an LDL-cholesterol-related disease or disorder using such compound(s), and kits and compositions comprising such compound(s).

Abstract: The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Compounds of Formula I are disclosed wherein R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A, R6B, R7, R8 and R9 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: A method for transmitting data to and from nodes of a multi-hop network with a TDMA scheme is suggested. The network is clustered into N clusters, wherein each cluster of the N clusters has at least one of the nodes. In a first step, the TDMA scheme is organized by periodic superframes. Each superframe of the periodic superframes has a number of frames including at least one broadcast frame and one collection frame for the N clusters. In a second step, one dedicated communication channel is shared by the N clusters within the broadcast frame. In a third step, N separate communication channels are used by the N clusters within the collection frame.

Abstract: The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Methods and systems for discovery of a set of nodes (20, 30) in a network (165). The method comprises selecting (S11) a node (20) amongst nodes in a group of nodes to be processed; and instructing (S12) to implement a discovery procedure for the selected node. The procedure comprises broadcasting (S22) a neighbor discovery request from a node (20) currently selected on a shared transmission medium (1) of the network; and receiving (S23) at the node (20) currently selected replies sent (S34) by neighbor nodes on the shared transmission medium and adding (S13) the neighbor nodes to the group of nodes to be processed; and repeating (S14) the steps of selecting and instructing for other nodes (30) in the group of nodes to be processed, until all nodes of the set are discovered.