Abstract: Compounds of Formula I are disclosed wherein R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A, R6B, R8 and R9 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: A method for synchronizing nodes of a multi-hop network with a Time Division Multiplex Access scheme (TDMA), the nodes being hierarchically arranged in different levels, including a step of organizing the TDMA by periodic superframes, the respective superframe having a number of frames including at least a broadcast frame, a step of providing the respective broadcast frame with a number of slots, the number of slots being equal to a number of parent nodes in the multi-hop network, a step of assigning each parent node one slot in the broadcast frame in dependence on its level, and a step of distributing a synchronization information to the parent nodes by means of the broadcast frame, respectively.

Abstract: A data network includes a plurality of source nodes, at least one sink node, and at least one intermediate node, wherein routing of a reverse message from the sink node to a source node via at least one intermediate node is performed by the intermediate node using reverse path routing information data comprising a combination of source routing information data and transparent bridging information data, wherein the reverse path routing information data is constructed during propagation of a forward message from the source node to the sink node via the intermediate node.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: A sensor network has a plurality of wireless sensors which transmit to an intermediate receiving device which relays data to a central server. A method is provided for receiving data packets at the intermediate receiving device from a plurality of the transmitting devices. Data packets are sensed on a communication medium at the receiving device and the total traffic intensity of data packets from the transmitting devices is estimated. A detection threshold for data packets is provided and adapted as a function of the total intensity. The receiving device receives data packets with a signal strength above the current detection threshold.

Abstract: The present invention discloses an apparatus and method for adapting a transmission parameter in a transmitting node of a data communication system to the current link quality of a data communication channel. The adapted transmission parameter is selected by the transmitting node from a set of transmission parameters in dependence on a number of successful transmissions. The number of successful transmissions is compared in the transmitting node against one of a first threshold value corresponding to a first state of the transmitting node and a second threshold value corresponding to a second state of the transmitting node.

Abstract: This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the thin film and provide protection to components encapsulated within. The invention further describes methods to incorporate bioactive components encapsulated within pH-sensitive polymeric microparticles into a quick-dissolving thin film strip while maintaining the bioactivity of the contained therapeutic agents during thin film formation and microencapsulation.

Abstract: A method for synchronizing nodes of a multi-hop network with a Time Division Multiplex Access scheme (TDMA), the nodes being hierarchically arranged in different levels, including a step of organizing the TDMA by periodic superframes, the respective superframe having a number of frames including at least a broadcast frame, a step of providing the respective broadcast frame with a number of slots, the number of slots being equal to a number of parent nodes in the multi-hop network, a step of assigning each parent node one slot in the broadcast frame in dependence on its level, and a step of distributing a synchronization information to the parent nodes by means of the broadcast frame, respectively.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: A sensor network has a plurality of wireless sensors which transmit to an intermediate receiving device which relays data to a central server. A method is provided for receiving data packets at the intermediate receiving device from a plurality of the transmitting devices. Data packets are sensed on a communication medium at the receiving device and the total traffic intensity of data packets from the transmitting devices is estimated. A detection threshold for data packets is provided and adapted as a function of the total intensity. The receiving device receives data packets with a signal strength above the current detection threshold.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: A data network includes a plurality of source nodes, at least one sink node, and at least one intermediate node, wherein routing of a reverse message from the sink node to a source node via at least one intermediate node is performed by the intermediate node using reverse path routing information data comprising a combination of source routing information data and transparent bridging information data, wherein the reverse path routing information data is constructed during propagation of a forward message from the source node to the sink node via the intermediate node.

Abstract: Fused pyrimidine compounds of structural formula (I) are effective as antagonists of the biological activity of the GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and Metabolic Syndrome.

Abstract: A sensor network has a plurality of wireless sensors which transmit to an intermediate receiving device which relays data to a central server. A method is provided for receiving data packets at the intermediate receiving device from a plurality of the transmitting devices. Data packets are sensed on a communication medium at the receiving device and the total traffic intensity of data packets from the transmitting devices is estimated. A detection threshold for data packets is provided and adapted as a function of the total intensity. The receiving device receives data packets with a signal strength above the current detection threshold.

Abstract: A sensor network has a plurality of wireless sensors which transmit to an intermediate receiving device which relays data to a central server. A method is provided for receiving data packets at the intermediate receiving device from a plurality of the transmitting devices. Data packets are sensed on a communication medium at the receiving device and the total traffic intensity of data packets from the transmitting devices is estimated. A detection threshold for data packets is provided and adapted as a function of the total intensity. The receiving device receives data packets with a signal strength above the current detection threshold.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: Compounds of formula (I): are found to be selective inhibitors of cathepsin B, and hence useful in treating a variety of pathological conditions.

Abstract: Methods support a sleep mode for an embedded device. Embedded devices like sensors and actuators used in wireless sensor networks have a limited power supply. To conserve energy and thus increase the lifetime of these devices, the devices should be put into a stand-by mode (also called sleep-mode) when they are not used. These methods support the sleep mode at a higher level than the MAC layer, thus avoiding the problems of prior art approaches. Methods are exemplarily described for the case of the message queuing telemetry transport protocol for sensor networks. They can easily be adapted to other protocols.

Abstract: Provides apparatus, systems and methods for adapting a first and second transmission parameter R, P in a transmitting node of a data communication system to the current link quality of a data communication channel. A method comprises in the transmitting node counting the number of successful transmissions s, each successful transmission bases on a receipt of an acknowledgment “ACK”, and comparing the number of successful transmissions s against a threshold value Smax. In the event of reaching the threshold value Smax and operating with the first and second transmission parameter R, P in a predetermined parameter space, the method further comprises adapting at least one of the first and second transmission parameters R, P in dependence on a critical value that due to the current link quality corresponds to a temporarily unsupported value of one of the first and second transmission parameters R, P.

Abstract: A sensor network has a plurality of wireless sensors which transmit to an intermediate receiving device which relays data to a central server. A method is provided for receiving data packets at the intermediate receiving device from a plurality of the transmitting devices. Data packets are sensed on a communication medium at the receiving device and the total traffic intensity of data packets from the transmitting devices is estimated. A detection threshold for data packets is provided and adapted as a function of the total intensity. The receiving device receives data packets with a signal strength above the current detection threshold.