Abstract: A medical injector is provided herein which includes first and second body portions each having a longitudinal axis and configured to couple at a coupling. The first and second body portions are complementarily formed so as to be movable about the coupling. The medical injector also includes an axially-displaceable plunger; biasing element for advancing the plunger a predetermined distance; and, a releasable retainer for releasably retaining the plunger in a first state against the force of the biasing element. In an initial state, the axes of the first and second body portions are not aligned and the plunger is in the first state. In a coupled state, the axes of the first and second body portions are axially aligned, and the releasable retainer releases the plunger, thereby allowing the biasing element to advance the plunger the predetermined distance.

Abstract: A medical injector is provided herein having a body and a needle mounting surface movable relative to the body, the needle mounting surface having features for mounting a needle thereto. In an initial state, the needle mounting surface is disposed within the body with no needle mounted thereto. With relative movement between the body and the needle mounting surface, the needle mounting surface is urged out of the body. Advantageously, a medical injector is provided which ensures proper sequence in preparation of the device, particularly with respect to the step of allowing mounting of a medical needle to the device subsequent to preparation of the medicament to be administered.

Abstract: In one aspect of the subject invention, a drug delivery device is provided which includes a reservoir for containing a medicament and has a proximal end and a distal end, the medicament including a suspension of solids in a liquid carrier. Further, the drug delivery device includes a needle in fluid communication with the reservoir and having a distal end for injection into a patient, and a proximal end in the reservoir. An accumulation surface is defined at least partially about the needle, distally of the proximal end of the needle. The accumulation surface defines a distally-extending indentation which is sized and shaped to collect, during use, solids that come out of suspension. Advantageously, with the subject invention, the accumulation surface allows for solids to accumulate at a location spaced from the proximal end of the needle, thereby minimizing the possibility of clogging the needle.

Abstract: A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir, wherein the device can be attached to a skin surface via an adhesive contact surface and a push button activation assembly can then be used to remove an interlock, allowing a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir, allow the release of the patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents. The push button activation assembly further allows the release of one or more improved safety mechanisms after use.

Abstract: A medical injector is provided herein having a body; a reservoir containing first and second mixable component; a stopper; a plunger; a spring disposed to advance the plunger; a first releasable retainer for releasably retaining the plunger in a first state against force of the spring; a first trigger for causing the first releasable retainer to release the plunger; a second releasable retainer for releasably retaining the plunger in a second state against force of the spring; and, a second trigger for causing the second releasable retainer to release the plunger. The spring causes the plunger to advance so that the stopper traverses at least a predetermined extent of advancement thereby causing mixing of the first and second mixable components. Advantageously, with the subject invention, a medical injector is provided which allows for autoreconstitution with subsequent dose setting and autoplunger activation being activated by separate triggers.

Abstract: A plate with housings for receiving objects for bulking, each housing being delimited by lateral walls and comprising a support zone for receiving the object for bulking. Each housing is formed by a cell with the lateral walls delimiting the cells adjoining one another from one cell to an adjacent cell and extending in a direction substantially perpendicular to the plane of the plate. Each cell is shaped to at least partially receive the proximal part of an object for bulking and each cell immobilizes each object for bulking.

Abstract: A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle.

Abstract: A system and method for a patch-like, self-contained substance infusion device (700) which can be attached to a skin surface via an adhesive contact surface. A push button (780) activation assembly can then be used to remove an interlock (730), allowing a disk or Belleville spring (735) assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly (710). This allows the release of one or more spring-loaded patient needles (760) into the skin surface, and establishes a fluid communication path between the patient needles (760) and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button (780) activation assembly further allows the release of one or more improved safety mechanisms (794) after use.

Abstract: The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and, an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.

Abstract: A medical injector is provided herein having a body and a reservoir disposed in the body, the reservoir including at least first and second mixable components. At least one stopper is associated with the reservoir where distal advancement of the stopper over a predetermined distance causes mixing of the mixable components. A plunger is disposed in the body, along with a knob stem and a knob fixed to the knob stem so as to be rotatable therewith. A sleeve is telescopingly disposed over the knob stem, wherein the knob stem and the sleeve have cooperating elements formed thereon which selectively permit rotation of the knob stem to be transmitted to the sleeve so that the knob stem and the sleeve may rotate together. A spring is also provided for urging the sleeve distally. A releasable retainer releasably retains the sleeve against force of the spring. Rotation of the knob releases the sleeve and allows the spring to displace the sleeve distally.

Abstract: A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.

Abstract: A drug delivery device (100) includes a body (102, 116) having a reservoir (160) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (160) and the patient. The device (100) also includes a plunger (144) movable within the body (102, 116) for causing the medicament to be expelled from the reservoir (160), and a biasing means (140) for biasing the plunger (144) toward the reservoir (160), wherein in a pre-activated position, the biasing means (140) telescopes within itself, and upon activation, provides a force to the plunger (144) for expelling the medicament from the reservoir (160). The biasing means (140) is preferably provided in the form of a conical spring having a variable pitch.

Abstract: A drug delivery device (100), including a body (104, 116) having a reservoir (164, 176) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (164, 176) and the patient. The device (100) also includes a needle cover (114) for selectively covering the injection needle (152), an adhesive (264) for selectively adhering the device to the patient, a release liner (500) for selectively covering a patient side of the adhesive (264), and a connecting means (112, 520, 512, 508, 524) for connecting the needle cover (114) and the release liner (500) such that removal of one of the needle cover (114) and the release liner (500) from the device (100) removes the other one of the needle cover (114) and the release liner (500).

Abstract: A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).

Abstract: A medical injector is provided herein which includes first and second body portions rotatably coupled together; a displaceable plunger disposed in at least one of the first and second body portions; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first portion against force of the spring. The releasable retainer releases the plunger upon a predetermined extent of relative rotation between the first and second body portions, thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon rotation of injector body portions, thereby minimizing premature or failed activations.

Abstract: A delivery device for delivery of a medicament to a user including a container defining a reservoir storing the medicament, a body in which the container is received, a spray nozzle arranged on one of the body and the container for receiving medicament expelled from the container, and a pusher actuatable for pushing the medicament from the container reservoir through the nozzle, said pusher being movable from a rest position to a fully activated position relative to said body in response to an actuating force. The assembly is particularly applicable to nasal syringes where it is desirable to deliver the medicament in the form of a spray.

Abstract: A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

Abstract: A filling system for syringes utilizing short needles to be filled from a vial having a thick septum is described. The system may be useful in any situation where the septum or vial stopper of a medication container is thicker than the usable length of the needle on the delivery device. Preferably, the syringe is filled just prior to use. The short needle includes an optional limiter which only permits a certain predetermined length of the needle cannula to protrude beyond the limiter a distance which limits penetration of the needle tip into both the skin and a vial stopper. The system and adapter may be useful for needles having a protrusion distance from approximately 0.5 mm to 3 mm, or any needle with a protrusion length shorter that the thickness of a septum to be accessed. Furthermore, a device is provided with shielding capabilities to shield the needle of the device.

Abstract: A cartridge or injector for holding and mixing a medical product is provided herein including a tubular body having a cylindrical wall having first and second opposing ends. The wall includes inner and outer surfaces with the inner surface having a generally constant cross-section along at least a drug mixing area. A first stopper is slidably disposed within the wall between the first and second ends, the first stopper defining a liquid-tight seal with the inner surface. A second stopper is slidably disposed within the wall between the first stopper and the first end, the second stopper defining a liquid-tight seal with the inner surface. A flexible insert is disposed at or in proximity to the second end, the insert forming a liquid-tight seal with the wall, the insert being pierceable by a medical needle or other piercing instrument. A rigid retainer is fixed to the wall having an opening therein for providing access to the insert for piercing by a medical needle.

Abstract: With the subject invention, a container for an injection device with an injection needle is provided. The container includes a body having a compartment formed therein to accommodate the injection device in both a pre-use and a post-use condition. The body defines a first opening through which the injection device in its pre-use condition may be accessed, and the body defines a second opening into which the injection device may be directed in its post-use condition. A closure is provided for closing the first opening. The container also includes a retainer proximate the second opening for retaining the injection device in the container in its post-use condition preventing access to the injection needle after the injection device has been used to administer an injection.