Abstract: Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) wherein the mutant allele is selected from the group consisting of the ELANE mutants set forth in Table 1, the method comprising introducing to the cell a composition comprising: a CRISPR nuclease or a sequence encoding the CRISPR nuclease; and a first RNA molecule comprising a guide sequence portion having 17-30 nucleotides, wherein a complex of the CRISPR nuclease and the first RNA molecule affects a double strand break in the mutant allele of the ELANE gene the method optionally further comprising introduction of a second RNA molecule comprising a guide sequence portion capable of complexing with a CRISPR nuclease, wherein the complex of the second RNA molecule and CRISPR nuclease affects a second double strand break in the ELANE gene.

Abstract: A method, product, and system comprising: rendering a webpage, said rendering comprises generating a HyperText Transfer Protocol (HTTP) packet to request the webpage from a server, the HTTP packet is absent of referral information in a referrer field, said rendering comprises communicating the HTTP packet to the server; obtaining from a user a first command to return from the webpage to a previous page, the previous page was rendered immediately before said rendering the webpage; based on the referrer field, dynamically modifying the webpage to present content of a publisher of the webpage instead of returning to the previous page; and in response to obtaining from the user a second command to return to the previous page, navigating to the previous page.

Abstract: New exemplary systems using a laser beam generated by a transmitter unit in abase station, for detecting, communicating with and controlling devices, typically battery-operated, installed in public spaces. Interaction between the laser beam and the device uses a laser detector module on the device, selected to emit a fluorescent signal when the laser beam impinges thereon. A fluorescence detector is installed on the base station, and it detects the incoherent fluorescence emitted by the device when the laser impinges on the device. A wireless data link can implement the exchange of information and instructions between the base station and the device, that may be needed following positive detection of the fluorescent emission from the device. The system may use a laser beam in the short wavelength infra-red (SWIR) region. The detector may provide the device with power for its operation and/or for keeping an installed battery charged.

Abstract: A system for ensuring the integrity of the enclosure of a wireless power transmitter. The enclosure of the transmitter comprises a window in order to allow a high-power beam to exit the transmitter. The window is equipped with an area which reflects at least a portion of the beam, and directs the reflected beam onto a detector. Thus the system can ascertain whether the window is undamaged, since if the detector is receiving a satisfactory portion of the beam, then it is indicative of an undamaged window. This advantageously prevents dangerous beam generated damage which may be caused if the exit window of the transmitter is damaged. The laser beam is preferably circularly polarized before exiting the transmitter to prevent dangerous laser damage caused by the reflections of the maximum of the P or S polarization components, which may occur with linearly polarized beams.

Abstract: Methods for inactivating a mutant human guanylate cyclase 2D (GUCY2D) allele comprising delivering a gRNA having a crRNA comprising at least 17 contiguous nucleotides set forth in any one of SEQ ID NOs: 237, 238, 241, 242, 247, 248, 394, 307, 413, 414, 417, 418, or 3011, compositions thereof, and methods of preventing, treating, ameliorating or slowing the progression of cone-rod dystrophies.

Abstract: A safety supervision system for wireless power transmission, comprising a transmitter having an optical beam generator with safe states for transmitting power to receivers that convert the beam into electrical power. The system control unit stores previously known signatures categorized by predetermined parameters associated with one or more unwanted situations, stores data from sensors, compares this stored data to the signatures, and executes one or more responses based on this comparison. The system may comprise transmitter and/or receiver malfunction detection systems adapted to monitor the transmitter and receiver control units and to cause the optical beam generator to switch to a safe state upon detection of a transmitter or receiver control unit malfunction, and may further comprise a hazard detection system preventing human exposure to beam intensity above a predefined safe level.

Abstract: Systems for the aiming of a laser beam of wireless power towards the photovoltaic cell of a receiver, using an adjustable beam deflection unit, enabling accurate orientation of the mirror used to deflect the laser beam. Insufficient aiming accuracy may result in the spilling over of beam energy intended for absorption by the photovoltaic cell, into the surroundings. The criteria of accuracy and stability required of an electronically controlled beam aiming mirror must be such that the angular deviation of a beam, from the direction intended by the electronic control, is such that the level of optical power transferred into the surroundings, when a beam having the maximum power which the system can transmit is aimed at the target, does not exceed that allowed by a regulatory requirement. One common regulation limits the allowed dissipated power to the power of a class 3B laser.

Abstract: A system for transmitting wireless power from multiple sources to multiple receivers, in which the safety of the system is maintained in spite of the possibility that two beams may intersect in the transmission space, thereby generating power or power density levels which exceed those at which the safety mechanisms of the system were designed to operate. The paths of the beams are known from the transmission positions and directions, and from the positions and orientations of the receivers, as measured by positioning devices on them. When an intersection, or near intersection of beams is determined, the system is triggered to reduce the safety risk by attenuating or turning off, or by diverting, one or more of the beams. In addition, since a reflected beam's path may not be readily discernable, the system can ascertain if one of the beams has undergone a reflection, by looking for displayed mirror images.

Abstract: Methods and systems for safely and effectively supplying a beam of wireless power from a transmitter to at least one receiver. A delta signal is generated by repeatedly calculating the difference in power between the power of the beam emitted by the transmitter and the amount of power received at the receiver. The system dynamically generates a time delay, which is a time period shorter than the maximal exposure duration relating to safe exposure durations for the power level of the delta signal. If the time delay is exceeded, the system changes an operational parameter of the system, such as terminating the beam. Because of limitations to building a perfect timing system, the system is built to be more sensitive to time delays having longer safe exposure durations, with large delta signals having short safe exposure durations being responded to immediately and without significant regard to the time delay.

Abstract: A wireless power transmitter for powering a remote receiver using a laser beam, the laser beam generator having current inputs and outputs electrically insulated from their surroundings, and each including a separate controlled gated switch. The transmitter has a beam adjustment element for switching the beam between a collimated beam for power transfer, and a more divergent beam for scanning, which is performed by a beam deflector. A detection system detect the presence of a receiver, and is used to ensure accurate beam impingement on the power receiving element. A controller senses when the beam is centered on the power receiving element, switches from the divergent scanning beam to the collimated beam, and instructs the beam generator to raise the power of the laser beam to a level for powering the receiver. The gate controller operates at a higher voltage than the other system control circuits.

Abstract: A safety supervision system for wireless power transmission, comprising a transmitter having an optical beam generator with safe states for transmitting power to receivers that convert the beam into electrical power. The system control unit stores previously known signatures categorized by predetermined parameters associated with one or more unwanted situations, stores data from sensors, compares this stored data to the signatures, and executes one or more responses based on this comparison. The system may comprise transmitter and/or receiver malfunction detection systems adapted to monitor the transmitter and receiver control units and to cause the optical beam generator to switch to a safe state upon detection of a transmitter or receiver control unit malfunction, and may further comprise a hazard detection system preventing human exposure to beam intensity above a predefined safe level.

Abstract: A system for transmitting wireless power from multiple sources to multiple receivers, in which the safety of the system is maintained in spite of the possibility that two beams may intersect in the transmission space, thereby generating power or power density levels which exceed those at which the safety mechanisms of the system were designed to operate. The paths of the beams are known from the transmission positions and directions, and from the positions and orientations of the receivers, as measured by positioning devices on them. When an intersection, or near intersection of beams is determined, the system is triggered to reduce the safety risk by attenuating or turning off, or by diverting, one or more of the beams. In addition, since a reflected beam's path may not be readily discernable, the system can ascertain if one of the beams has undergone a reflection, by looking for displayed mirror images.

Abstract: A wireless optical power transmission system comprising a transmitter and receiver, the transmitter comprising a laser emitting a beam, a scanning mirror for steering the beam towards said receiver and a control unit receiving signals from a detection unit on the receiver and controlling the beam power and the scanning mirror. The receiver has a photovoltaic cell having a bandgap energy of 0.75-1.2 eV, with a plurality of conductors on a beam receiving surface. A cover layer of material blocking illumination of wavelengths outside that of the laser, is disposed on the photovoltaic cell. The cover layer may have anti-reflective coatings on its top and bottom surfaces. The detection unit thus generates a signal representing the power of the laser beam impinging upon the receiver, independent of illuminations other than that of said laser beam. The control unit thus can maintain the laser power impinging on the receiver.

Abstract: A system for safe transmission of an RF electromagnetic power beam to a receiver for conversion into electric power. The receiver has an antenna array for receiving the RF beam and electrical circuitry to receive a corresponding RF electrical current from the antenna array. The circuitry includes a converter for generating DC current from the RF electrical current, and includes at least one component that reflects part of the RF current back towards the antenna array. This converts the reflected portion of the RF electrical current into a retransmitted RF electromagnetic beam having the same frequency as the RF electromagnetic power beam, and is directed back towards the transmitter. The receiver monitors the reflected RF current, and transmits a proportional signal back to a controller. The controller reduces the transmitted power beam if its interference with the retransmitted beam would generate a field intensity above a safe level.

Abstract: A laser system involving coupled distributed resonators disposed serially, with the lasing gain medium located in the main resonator and the output of that resonator being directed into a free space resonator, such that the main resonator output mirror is effectively the free space resonator. The distributed resonators end mirrors are retroreflectors. Interference occurs between light traveling towards the remote mirror of the free space resonator and light reflected therefrom, generating regions of high reflectivity. The coupling of the free space resonator to the regions of high reflectivity of the free space resonator enables the first resonator to lase efficiently, even though the true reflectivity of the main resonator output mirror outside of those regions is insufficient to enable efficient lasing, if at all. This coupled resonator structure enables lasing to occur with a high field of view and the high gain engendered by the high reflectivity regions.

Abstract: A wireless power transmitter system for directing a high energy beam towards receivers fitted with identifying signs. One type of the identifying signs may have asymmetric shape properties, such that their mirror image cannot be matched to their actual shape, even after the image is rotated, tilted or otherwise geometrically manipulated. The system can thus determine whether a detected image of a sign is a true image received directly from said receiver, or is received after the imaged beam has undergone a reflection between the receiver and the transmission system. In the latter case, the system can prevent high power transmission from being directed to a location other than a real receiver, which could be a safety hazard. Other types of identifying signs may be located in or on the borders of different zones of a transmission space, to identify zones where transmission may be allowed or prohibited.

Abstract: A wireless optical power transmission system comprising a transmitter and receiver, the transmitter comprising a laser emitting a beam, a scanning mirror for steering the beam towards said receiver and a control unit receiving signals from a detection unit on the receiver and controlling the beam power and the scanning mirror. The receiver has a photovoltaic cell having a bandgap energy of 0.75-1.2 e V, with a plurality of conductors on abeam receiving surface. A cover layer of material blocking illumination of wavelengths outside that of the laser, is disposed on the photovoltaic cell. The cover layer may have anti-reflective coatings on its top and bottom surfaces. The detection unit thus generates a signal representing the power of the laser beam impinging upon the receiver, independent of illuminations other than that of said laser beam. The control unit thus can maintain the laser power impinging on the receiver.

Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.

Abstract: A receiver for receiving an incident beam of optical power from a remote transmitter over a predefined field of view, comprising an input lens having a high durability coating that can withstand domestic handling and contamination. Such a high durability coating may reflect a non-insignificant part of the light incident thereon. Behind the lens, there is fitted a retroreflector disposed such that it reflects that part of the incident beam traversing the lens, back through the lens to the transmitter. Reflections from the front surface of the lens impinge on one or more transparent beam catchers appropriately located, and equipped with energy conversion devices, such as photovoltaic cells, to convert light from the reflections of the incident beam into electricity. Additional energy conversion devices may be located inward of the lens, to collect and convert reflections from the inner surface of the lens, of light returning from the retroreflector.

Abstract: A method, product, and system comprising: rendering a webpage, said rendering comprises generating a HyperText Transfer Protocol (HTTP) packet to request the webpage from a server, the HTTP packet is absent of referral information in a referrer field, said rendering comprises communicating the HTTP packet to the server; obtaining from a user a first command to return from the webpage to a previous page, the previous page was rendered immediately before said rendering the webpage; based on the referrer field, dynamically modifying the webpage to present content of a publisher of the webpage instead of returning to the previous page; and in response to obtaining from the user a second command to return to the previous page, navigating to the previous page.