Abstract: This disclosure relates to GSPT1 degrader compounds (e.g. small molecule compounds), compositions comprising one or more of the compounds, and to methods of use the compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such compounds.

Abstract: A preparation method of itaconate-butadiene bio-based engineering rubber belongs to the bio-based engineering rubber area. The bio-based engineering rubber of the present disclosure is formed through chemical crosslinking of copolymers, which are formed by polymerization of itaconate and butadiene emulsion. The number average molecular weight of the itaconate-butadiene copolymer is about 53000-1640000, and weight-average molecular weight is about 110000-2892000. Itaconate-butadiene copolymers are formed by polymerization of itaconate and butadiene emulsion, then and chemical crosslinking of the copolymer is performed to form bio-based engineering rubber using a traditional sulfur vulcanizing system. The bio-based engineering rubber has high molecular weights as well as lower glass-transition temperatures and can be vulcanized using the traditional sulfur vulcanizing system.

Abstract: Aspects of the disclosure are directed to jointly searching machine learning model architectures and hardware architectures in a combined space of models, hardware, and mapping strategies. A search strategy is utilized where all models, hardware, and mappings are evaluated together at once via weight sharing and a supernetwork. A multi-objective reward function is utilized with objectives for quality, performance, power, and area.

Abstract: The present invention provides an image sensor and a method for fabricating the image sensor. The image sensor includes a semiconductor substrate, photodiodes (PD), deep isolation trenches, first deep P-well blocks and second deep P-wells. The isolation trenches surrounds the PDs, and each of the isolation trenches is separated from any adjacent isolation trenches at a crossing where they would have crossed each other if they further extended. The first deep P-wells blocks have projections on the semiconductor substrate, which encompass projections of said separated portions of the isolation trenches on the semiconductor substrate. The first P-well blocks can be formed using only one photomask, resulting in a reduction in cost.

Abstract: A method and device for smoke or fire recognition, a computer device and a storage medium are disclosed. The method includes: acquiring a to-be-recognized image in a smoke or fire monitoring region; recognizing a smoke or fire suspected region in the to-be-recognized image according to the to-be-recognized image, including recognizing a smoke or fire suspected region in a visible light image on the basis of colors, and recognizing a smoke or fire suspected region in an infrared image on the basis of brightness; and inputting the to-be-recognized image including the smoke or fire suspected region into a preset model, and recognizing a smoke or fire state in the to-be-recognized image according to an output result of the preset model, the preset model being obtained by training based on the visible light image pre-marked with a smoke or fire state or the infrared image pre-marked with a smoke or fire state.

Abstract: An impedance control method as well as a controller and a robot using the same are provided. The method includes: obtaining joint motion information and joint force information in the joint space of a robotic arm and an actual interaction force acting on an end-effector, and calculating actual motion information of the end-effector in the task space based on the joint motion information; calculating a corrected desired trajectory using environment information and a desired end-effector interaction force, and calculating the impedance control torque based on the joint force information, the actual interaction force, the actual motion information, and desired end-effector information including the corrected desired trajectory and determining a compensation torque based on a nonlinear term in a constructed dynamics equation so as to perform a joint torque control on the robotic arm based on the impedance control torque and the compensation torque.

Abstract: An inverse kinematics solving method for redundant robot as well as a redundant robot using the same are provided. The method includes: obtaining an expression of a Jacobian matrix null space of a current configuration of each robotic arm of the redundant robot corresponding to a preset end pose of the robotic arm according to the preset end pose, and obtaining a relation between an angular velocity of the joints of the redundant robot in the Jacobian matrix null space of the current configuration based on the obtained expression; traversing the Jacobian matrix null space using the relation, and building an energy cost function of the redundant robot based on the relation; obtaining a target joint angle of each joint of the redundant robot based on the optimal inverse kinematics solution to transmit to the servo of the joint so as to control the joint.

Abstract: A method for preparing a tar extract with aroma characteristics from a discarded cigarette butt includes: (1) adding the discarded cigarette butt to an extraction solvent, and carrying out subcritical fluid extraction to obtain an extraction solution; (2) carrying out vacuum filtration on the extraction solution, and carrying out vacuum distillation on the filtrate to obtain a concentrated extractum; and (3) carrying out molecular distillation on the concentrated extractum, and collecting a light fraction of the molecular distillation to obtain the tar extract with aroma characteristics. Through the subcritical fluid extraction and separation by the molecular distillation to prepare the tar extract, harmful substances in the tar are removed, and the aroma components are retained. The tar extract is applied to a cigarette to improve the aroma, smoke and taste characteristics of the cigarette.

Abstract: The present invention provides a scrubbing robot, including a window scrubbing device, including a suction assembly configured to be sucked to a window body, a first travelling assembly configured to move on the window body, and a window body cleaning system; and a floor scrubbing device, including a second travelling assembly configured to move on a floor and a floor cleaning system, where the body of the floor scrubbing device has a mounting recess, and the window scrubbing device is configured to be capable of being embedded into and removed from the mounting recess. The scrubbing robot is an integrally functional cleaning robot integrating multiple functions of floor sweeping, floor scrubbing, and window scrubbing.

Abstract: The present disclosure relates to text data processing methods and apparatuses. One example method includes obtaining target text, where a phoneme of the target text includes a first phoneme and a second phoneme that are adjacent to each other. Feature extraction is performed on the first phoneme and the second phoneme to obtain a first audio feature of the first phoneme and a second audio feature of the second phoneme. By using a target recurrent neural network (RNN) and based on the first audio feature, first speech data corresponding to the first phoneme is obtained.By using the target RNN and based on the second audio feature, second speech data corresponding to the second phoneme is obtained.By using a vocoder and based on the first speech data and the second speech data, audio corresponding to the first phoneme and audio corresponding to the second phoneme are obtained.

Abstract: A hybrid braided stent includes a stent body (20). The stent body (20) is a single-layer structure. The stent body (20) is a tubular structure formed by interweaving a plurality of filaments. The end areas of at least two of the plurality of filaments are different.

Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.

Abstract: A display panel includes a substrate, a plurality of light-emitting devices, a first encapsulation layer, and a first dielectric layer. The first encapsulation layer includes a first portion and a second portion at least partially surrounding the first portion. The first dielectric layer is located between the first encapsulation layer and the plurality of light-emitting devices. Along the direction perpendicular to the plane of the display panel, a distance between a surface of the first portion away from at least one light-emitting device of the plurality of light emitting devices and a surface of the third portion away from the at least one light-emitting device is smaller than a distance between a surface of the second portion away from the at least one light-emitting device and a surface of the fourth portion away from the at least one light-emitting device.

Abstract: Embodiments of the present disclosure provide a switch assembly for a detection unit of a switchgear or controlgear.

Abstract: Disclosed is an improved approach for efficiently implementing a three-dimensional integrated circuit (3D-IC) design with heterogeneous and/or homogeneous dies. A first die design and a second die design in a three-dimensional (3D) electronic design maybe identified, and a wrapper design may be generated for at least a block of circuit component designs in the second die design for concurrent implementation of both the first and the second die designs. Both the first and the second dies of the 3D electronic design are concurrently implemented based at least upon a floorplan that is generated with at least the wrapper design for the 3D electronic design. A first wrapper and a second wrapper may be respectively generated for the first die design and the second die design based at least in part upon a result of the concurrent implementation.

Abstract: According to various implementations, generally disclosed herein is a hybrid and hierarchical neural architecture search (NAS) approach. The approach includes performing a search space partitioning scheme to divide the search space into sub-search spaces. The approach further includes performing a first type of NAS, such as a Multi-trial NAS, to cover a search across the sub-search spaces. The approach also includes performing a second type of NAS, such as a One-Shot NAS, to cover each sub-search space. The approach further includes automatically stopping the second type of NAS based on one or more early stopping criteria.

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Abstract: The present disclosure provides a robotic arm space position adjustment method, a robotic arm controller, and a computer readable storage medium. The method includes: calculating a potential energy function of moving a feature point of the robotic arm to a reference point based on an obtained preset acceleration of an artificial gravitational field, first vector of the artificial gravitational field in a preset reference coordinate system, second vector of the feature point of the robotic arm in the preset reference coordinate system, and a third vector of the reference point in the preset reference coordinate system; and calculating a null space virtual moment of moving the feature point of the robotic arm to the reference point based on a preset null space operator and the potential energy function, so as to adjust each joint of the robotic arm.