Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: Provided are an image display method and apparatus, an electronic device, and a medium, which relate to the field of computer technologies, in particular to the fields of cloud phones, cloud computing and cloud services. The specific implementation scheme is as follows: generating a simulated external display of a cloud device according to an acquired target resolution of a target client; and generating frame buffer data according to a frame buffer area of the simulated external display in the cloud device, and sending the frame buffer data to the target client so that the target client performs image display on a target interface according to the frame buffer data.

Abstract: Disclosed are a tartrate of 3-(5-fluoro-4-(4-methyl-2-(methylamino)thiazol-5-yl) pyrimidin-2-ylamino)-benzenesulfonamide and a polymorph thereof, which are inhibitors of protein kinases, in particular cyclin-dependent kinase 9 (CDK9), and can be used to treat proliferative disorders, such as cancer, and other diseases related to protein kinase/CDK activity.

Abstract: A method is proposed for providing a content page in an application. In the method, a media item is generated, and the media item is associated with respective resources in a resource list that is received from a resource provider. The media item is presented in the application. A content page is caused to be displayed in response to detecting an interaction event of a user of the application with the media item, the content page including respective content items for the respective resources. Therefore, the media item and the content page are generated and displayed in an automatic way for the one or more resource providers without any label work from the resource providers.

Abstract: According to an example, key splitting may include utilizing a masked version of a master key that is masked by using a mask.

Abstract: Provided are anti-PD-1 antibodies or fragments thereof. In various example, the antibodies or fragments thereof includes a heavy chain variable region comprising heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3, and a light chain variable region comprising light chain complementarity determining regions LCDR1, LCDR2, and LCDR3. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer, infection or immune disorders are also provided.

Abstract: The present disclosure provides a method for extracting tar aroma components from a cigarette butt and use of the tar aroma components in a cigarette. The method includes the following steps: (1) adding the cigarette butt to an extraction solvent, and carrying out ultrasound-assisted extraction to obtain an extraction solution; (2) centrifuging the extraction solution, and carrying out vacuum distillation on the supernatant to obtain a concentrated extractum; and (3) carrying out molecular distillation on the concentrated extractum, and collecting a light fraction of the molecular distillation to obtain the tar aroma components. In the present disclosure, the cigarette butt is used as a raw material, through the ultrasound-assisted extraction and separation by the molecular distillation to extract the tar, harmful substances in the tar are removed, and the aroma components are retained.

Abstract: This application discloses a power supply and a power system. A first power supply is configured to set an output voltage of the first power supply to a plurality of voltage values. A second power supply is configured to send a plurality of first parameters to the first power supply, where the first parameters are used to identify power efficiency of the second power supply. The first power supply is further configured to obtain a plurality of second parameters, which are used to identify power efficiency of the first power supply. The first power supply is further configured to determine, based on the plurality of first parameters and the plurality of second parameters, maximum power efficiency of the power system and a voltage value corresponding to the maximum power efficiency.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for scheduling operations represented as a computational graph on a distributed computing network. A method includes: receiving data representing operations to be executed in order to perform a job on a plurality of hardware accelerators of a plurality of different accelerator types; generating, for the job and from at least the data representing the operations, features that represent a predicted performance for the job on hardware accelerators of the plurality of different accelerator types; generating, from the features, a respective predicted performance metric for the job for each of the plurality of different accelerator types according to a performance objective function; and providing, to a scheduling system, one or more recommendations for scheduling the job on one or more recommended types of hardware accelerators.

Abstract: A method for preparing a tar extract from a discarded cigarette butt and use of the tar extract in a cigarette includes the following steps: (1) adding the discarded cigarette butt to an extraction solvent, and carrying out microwave-assisted extraction to obtain an extraction solution; and (2) centrifuging the extraction solution, carrying out silica gel column chromatography on the supernatant, carrying out elution by using a petroleum ether-ethyl acetate mixed solution as a mobile phase, and collecting the resulting elution fraction to obtain the tar extract. In the method, the tar is extracted from the discarded cigarette butt as a raw material. Through the microwave-assisted extraction and separation by the silica gel column chromatography, harmful substances in the tar of the cigarette butt are removed, and the components with aroma characteristics are retained, and the tar extract is applied to a low-end cigarette.

Abstract: A preparation method of a fluoropolymer processing aid. The preparation method comprises the following steps: simultaneously adding ?-caprolactone and a fluoropolymer elastomer into a reactor, and heating to completely dissolve the fluoropolymer elastomer; and then cooling, adding polyol, mixing thoroughly, and adding an organotin catalyst to carry out a polymerization reaction; and after the reaction is finished, carrying out cooling, pulverizing or spray granulation so as to obtain the fluoropolymer processing aid. The processing aid prepared by using the method can reduce the extrusion pressure of a polymer during extrusion, improve the processing efficiency, improve the phenomena of melt rupture and “sharkskin” during polymer extrusion, and effectively enhance the surface quality of a product.

Abstract: Embodiments of a disconnector and a switchgear, wherein the disconnector comprises a contact assembly operable to change a status of a circuit, the disconnector arranged in the circuit; shafts adapted to be driven to rotate to operate the contact assembly; and a transmission unit arranged between the shafts and comprising: a plurality of gears coupled to the shafts to enable the shafts to rotate with a mutual engagement of the plurality of gears; and a holding assembly adapted to hold radial positions of the plurality of gears to ensure the mutual engagement of the plurality of gears. By arranging the holding assembly to hold the radial positions of the gears to ensure the mutual engagement of the plurality of gears, only one input shaft and one transmission unit are enough to transmit large torques sufficient to operate the contact assembly.

Abstract: The present disclosure provides an attenuated Nocardia seriolae and its construction method and use thereof, which belongs to the technical field of genetic engineering. In the present disclosure, part or all of the glutamate endopeptidase homologue (GluNS) gene sequence of wild-type Nocardia seriolae is knocked out by means of genetic engineering to construct an attenuated strain with the characterized of good protection to the host. The attenuated strain may not only effectively reduce the pathogenicity of the bacteria, but also retain good immunogenicity. At the same time, the attenuated Nocardia seriolae constructed in the present disclosure may also have the characteristics of high genetic stability and may be used as a vaccine candidate strain for the preparation of a vaccine or other biological products for preventing and treating Nocardiosis.

Abstract: The present disclosure discloses a butenediol-based polyester elastomer and a method for preparing same. In the present disclosure, 1,4-butenediol containing high-stability double-bond is used to replace itaconic acid, and a series of butenediol-based polyester elastomers with high molecular weight and narrow distribution are synthesized, which have high relative molecular weight and narrow relative molecular weight distribution. The crosslinking in subsequent processing is more controllable, and the dosage of a vulcanizing agent is equivalent to that of traditional rubber.

Abstract: Embodiments of the present disclosure relate to a switch device, comprising: a first three-position switch; a second three-position switch disposed below the first three-position switch; a circuit breaker disposed between the first three-position switch and the second three-position switch. A first interlock unit is disposed above the circuit breaker and connected to the circuit breaker and the first three-position switch, and configured to block a manual operation of the first three-position switch in a closed state of the circuit breaker, and configured to block a manual closing operation of the circuit breaker while the first three-position switch is manually operated in an open state of the circuit breaker.

Abstract: A Onepass system inkjet printing control method, device and storage are provided. The method includes: dividing all physical channels into several groups according to a printing requirement command, defining one group as a printing module, wherein each of the printing modules includes x physical channels, x?1, x is an integer; configuring n logical channels for each printing module, wherein n?x, n is an integer; starting a printing command, and extracting corresponding printing data from the printing memory in units of the logical channel; processing the printing data according to the printing parameters and then inputting it into the corresponding physical channel for inkjet printing. The solution of the present invention ensures that each printing module can independently control the printing task during printing.

Abstract: The display panel includes a display region, where at least a portion of the display region is a transparent display region including a plurality of sub-regions, where the plurality of sub-regions are arranged in an array and have the same shape and the same area. A sub-region of the plurality of sub-regions includes a first side and a second side which are adjacent to each other. The sub-region includes a non-light-transmissive region and a light-transmissive region. A distance between a center of the light-transmissive region and a first side of a sub-region where the light-transmissive region is located is d1, a distance between the center of the light-transmissive region and a second side of the sub-region where the light-transmissive region is located is d2, and at least two of the plurality of sub-regions have at least one of different d1 or different d2.

Abstract: The present invention discloses an atrial fibrillation detection device, method, system and storage medium. The device includes an ECG signal processing module, configured to identify positions of Q, R, S and T points of all heartbeats in an ECG signal acquired in a preset time, and determine a RR interval, a P point amplitude, an R point amplitude and a TQ segment waveform of each heartbeat according to the positions of the P, Q, R, S and T positions; and a detection module, configured to acquire an integrated score and perform conditional judgment on the integrated score, wherein the fifth score is a quotient of a total number of f waves in all the TQ segment waveforms in the ECG signal to a total number of the TQ segment waveforms involved in the ECG signal.

Abstract: The invention relates to a method of preparing reclaimed rubber, especially using multi-stage screw extruders, which belongs to the field of recycling and reusing of waste rubber. The rubber powder and softener which were preliminarily mixed are compacted and added into first counter rotating twin screw extruder through thermal insulation and metering apparatus, the softener permeates the waste rubber powder uniformly under the action of temperature in the extruder to finish primary desulfurization of rubber waste powder; add preliminary devulcanized material continuously into second multi screw extruder after cooling by transformation device, rapid desulfurization and regeneration can be achieved by means of activator and shear action; The desulfurized rubber powder is cooled and transported into the third multi-screw extruder in series, the performance of deprocessing can be improved by shear action under low temperature; After extrusion, the recycled rubber is obtained by molding device and cooling device.

Abstract: Disclosed is an improved approach for implementing a three-dimensional integrated circuit design with mixed macro and standard cell placement. This approach concurrently places both the macros and standard cells of the 3D-IC design onto two or more stacked floorplan and optimize the instance locations by timing, density, wire length and floorplan constraint.