Patents by Inventor Lisa Collins

Lisa Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proteases and uses thereof
    Publication number: 20050260733
    Abstract: The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.
    Type: Application
    Filed: April 15, 2005
    Publication date: November 24, 2005
    Applicant: WYETH
    Inventors: Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Michael Agostino, Bethany Freeman, Maya Arai, Carl Flannery, Macy Jin
  • Secreted protein and polynucleotides encoding them
    Publication number: 20050250180
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: October 22, 2003
    Publication date: November 10, 2005
    Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20050003491
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: August 9, 2004
    Publication date: January 6, 2005
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Kenneth Jacobs, John McCoy, Edward LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael Agostino, Robert Steininger, Vikki Spaulding, Gordon Wong, Hilary Clark, Kim Fechtel
  • Protein kinase C zeta as a drug target for arthritis and other inflammatory diseases
    Publication number: 20040259136
    Abstract: The present invention is based on the discovery that &zgr;PKC expression is increased in the tissues of arthritis patients as compared to normal individuals. Accordingly, the present invention provides methods of diagnosing, prognosing, and monitoring the course of arthritis in a patient based on increased &zgr;PKC gene expression in arthritic tissue. The present invention further provides compounds that inhibit the expression of &zgr;PKC for use as remedies in the treatment of arthritis, including, but not limited to, inhibitory polynucleotides and polypeptides, small molecules, and peptide inhibitors. In addition, the present invention provides pharmaceutical formulations and routes of administration for such remedies, as well as methods for assessing their efficacy.
    Type: Application
    Filed: May 10, 2004
    Publication date: December 23, 2004
    Inventors: Edward R. LaVallie, Lisa A. Collins-Racie, Maya Arai
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040248256
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: December 9, 2004
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa Collins-Racie, David Merberg, Cheryl Evans, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Michael R. Bowman, Elizabeth DiBlasio-Smith, Angela Widom
  • Truncated aggrecanase molecules
    Publication number: 20040054149
    Abstract: Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: February 5, 2003
    Publication date: March 18, 2004
    Applicant: Wyeth
    Inventors: Katy E. Georgiadis, Tara K. Crawford, Kathleen N. Tomkinson, Lisa A. Collins-Racie, Christopher J. Corcoran, Bethany A. Freeman, Edward R. Lavallie
  • Aggrecanase molecules
    Publication number: 20040044194
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 31, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Christopher J. Corcoran, Michael J. Agostino, Edward R. Lavallie, Carl R. Flannery, Weilan Zeng, Lisa A. Collins-Racie, Bethany A. Freeman
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20040038276
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: July 8, 2003
    Publication date: February 26, 2004
    Applicant: GENETICS INSTITUTE, LLC.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, David Merberg, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Cheryl Evans, Maurice Treacy
  • Novel proteins
    Publication number: 20030166044
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: March 30, 2001
    Publication date: September 4, 2003
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy
  • SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20030096951
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: May 22, 2003
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MICHAEL J. AGOSTINO, ROBERT STEININGER, VIKKI SPAULDING, GORDON G. WONG, HILARY F. CLARK, KIM FECHTEL, CHERYL EVANS, MAURICE TREACY
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20030044935
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 21, 2000
    Publication date: March 6, 2003
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. La Vallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • Polynucleotides encoding novel secreted proteins
    Publication number: 20030027139
    Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.
    Type: Application
    Filed: March 29, 2001
    Publication date: February 6, 2003
    Inventors: Kenneth Jacobs, John McCoy, Edward R. LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Michael R. Bowman, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Steven H. Howes, Richard J. Resnick, Kalmalakar Gulukota, James R. Graham
  • HUMAN CHORDIN-RELATED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20020197666
    Abstract: Novel human chordin-related proteins and polynucleotides encoding them are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: December 26, 2002
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MAURICE TREACY, ELIZABETH DIBLASIO-SMITH, ANGELA WIDOM
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020193567
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Applicant: Genetics institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael R. Bowman, Vikki Spaulding, McKeough Carlin-Duckett, Kerry Kelleher
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020065394
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 22, 2000
    Publication date: May 30, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20010039335
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 4, 2000
    Publication date: November 8, 2001
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary Clark, Kim Fechtel