Patents by Inventor Lishan Zhao

Lishan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
    Patent number: 6979733
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: December 27, 2005
    Assignee: Diversa Corporation
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Publication number: 20050244937
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: November 3, 2004
    Publication date: November 3, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Paula Hicks, Sara McFarlan, Jim Millis, John Rosazza, Lishan Zhao, David Weiner
  • Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
    Patent number: 6943001
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: September 13, 2005
    Assignee: Diversa Corporation
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Chewing gum compositions comprising monatin and methods for making same
    Publication number: 20050170041
    Abstract: Chewing gum compositions are described that include one or more stereoisomers of monatin, a naturally occurring high-intensity sweetener.
    Type: Application
    Filed: August 16, 2004
    Publication date: August 4, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner
  • Monatin tabletop sweetener compositions and methods of making same
    Publication number: 20050112260
    Abstract: The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: August 2, 2004
    Publication date: May 26, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner
  • Beverage compositions comprising monatin and methods of making same
    Publication number: 20050106305
    Abstract: The present invention relates to novel beverage compositions comprising monatin and methods for making such compositions. The present invention also relates to beverage compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and/or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
    Type: Application
    Filed: August 25, 2004
    Publication date: May 19, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Melanie Goulson, Paula Hicks, Michael Lindley, Sara McFarlan, James Millis, John Rosazza, Lishan Zhao, David Weiner
  • Method to alter sugar moieties
    Publication number: 20040161839
    Abstract: A method to modify the structure of sugars is provided.
    Type: Application
    Filed: November 3, 2003
    Publication date: August 19, 2004
    Inventors: Hung-Wen Liu, David H. Sherman, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Publication number: 20030194784
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: October 15, 2002
    Publication date: October 16, 2003
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
    Publication number: 20030148490
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Application
    Filed: October 10, 2002
    Publication date: August 7, 2003
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
    Publication number: 20030148443
    Abstract: The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.
    Type: Application
    Filed: August 5, 2002
    Publication date: August 7, 2003
    Inventors: Lishan Zhao, Eric J. Mathur, David Weiner, Toby Richardson, Aileen Milan, Mark J. Burk, Bin Han, Jay M. Short
  • Methods for the Manufacture of pure single enantiomer compounds and for selecting enantioselective enzymes
    Publication number: 20030092033
    Abstract: The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes.
    Type: Application
    Filed: June 21, 2002
    Publication date: May 15, 2003
    Inventors: David Weiner, Tim Hitchman, Lishan Zhao, Mark J. Burk, Grace Desantis, Sarah Richardson Hanson, Aileen Milan, Toby Richardson, Patti Kretz, Willaiam Greenberg
  • Products encoded by a methymycin/pikromycin biosynthetic gene cluster
    Publication number: 20030087405
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: April 17, 2001
    Publication date: May 8, 2003
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Publication number: 20030073824
    Abstract: A biosynthetic gene cluster for methymycin and pikromycin as well as a biosynthetic gene cluster for desosamine is provided.
    Type: Application
    Filed: November 19, 2001
    Publication date: April 17, 2003
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Publication number: 20020164742
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: May 18, 2001
    Publication date: November 7, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • Polyketide synthase encoded by a methymycin/pikromycin biosynthetic gene cluster
    Publication number: 20020110897
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Application
    Filed: May 18, 2001
    Publication date: August 15, 2002
    Applicant: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao
  • DNA encoding methymycin and pikromycin
    Patent number: 6265202
    Abstract: A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: July 24, 2001
    Assignee: Regents of the University of Minnesota
    Inventors: David H. Sherman, Hung-Wen Liu, Yongquan Xue, Lishan Zhao