Patents by Inventor Livius Cotarca

Livius Cotarca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing a solid form of abiraterone acetate
    Patent number: 9920089
    Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of preparing micro size abiraterone or derivatives thereof in high yield and purity by means of a spherical agglomeration process.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: March 20, 2018
    Assignee: ZACH SYSTEM
    Inventors: Patricia Poirier, Yvon Derrien, Massimiliano Forcato, Livius Cotarca, Pierrick Morice
  • Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
    Patent number: 9604915
    Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 28, 2017
    Assignee: ZACH SYSTEMS S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Process for preparing Cinacalcet hydrochloride
    Patent number: 9522869
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: December 20, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Method of detecting polymorphs using synchrotron radiation
    Patent number: 9513237
    Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: December 6, 2016
    Assignee: ZETACUBE S.R.L.
    Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotto, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
  • Process for preparing gabapentin
    Patent number: 9481635
    Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
  • Process for preparing enantiomerically enriched oxamides
    Patent number: 9481686
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR PREPARING GABAPENTIN
    Publication number: 20160237025
    Abstract: The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.
    Type: Application
    Filed: October 21, 2014
    Publication date: August 18, 2016
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Massimo Verzini, Livius Cotarca, Fabio Belluzzo, Giorgio Soriato, Daniele Urbani, Enrico Pace
  • Process for preparing 17-substituted steroids
    Patent number: 9353145
    Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: May 31, 2016
    Assignee: ZACH SYSTEM
    Inventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
  • CYCLOPROPANATION OF SUBSTITUTED PHENYLACETONITRILES OR PHENYL ACETATES
    Publication number: 20160102049
    Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
    Type: Application
    Filed: June 20, 2014
    Publication date: April 14, 2016
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • PROCESS FOR PRODUCING A SOLID FORM OF ABIRATERONE ACETATE
    Publication number: 20160083416
    Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of preparing micro size abiraterone or derivatives thereof in high yield and purity by means of a spherical agglomeration process.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 24, 2016
    Applicant: ZACH SYSTEM
    Inventors: Patricia POIRIER, Yvon DERRIEN, Massimiliano FORCATO, Livius COTARCA, Pierrick MORICE
  • Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
    Patent number: 9290428
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: March 22, 2016
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Process for preparing a ketosulfone derivative
    Patent number: 9085532
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 21, 2015
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for Preparing Enantiomerically Enriched Oxamides
    Publication number: 20150191485
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Application
    Filed: June 28, 2013
    Publication date: July 9, 2015
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • The Process For Preparing a Ketosulfone Derivative
    Publication number: 20150133671
    Abstract: The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative.
    Type: Application
    Filed: March 8, 2013
    Publication date: May 14, 2015
    Inventors: Elisa Melotto, Ivan Michieletto, Vincenzo Frega, Livius Cotarca, Massimo Verzini, Franco Massaccesi, Ilaria Munari
  • Process for preparing nebivolol
    Patent number: 8969597
    Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: March 3, 2015
    Assignee: Zach System S.p.A.
    Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
  • Process for preparing Bosentan monohydrate and it's intermediates
    Patent number: 8933226
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: January 13, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • Asymmetric reduction process
    Patent number: 8927740
    Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: January 6, 2015
    Assignee: Zach System S.P.A.
    Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini
  • Process for preparing Nebivolol
    Patent number: 8927742
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: January 6, 2015
    Assignee: Zach Systems S.p.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1-(2-FLUORO[1,1'-BIPHENYL]-4-YL)-CYCLOPROPANECARBOXYLIC ACID
    Publication number: 20140378696
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group ?wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.
    Type: Application
    Filed: June 23, 2014
    Publication date: December 25, 2014
    Applicant: CHIESI FARMACEUTICI S.p.A
    Inventors: Massimo VERZINI, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
    Publication number: 20140296574
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini