Patents by Inventor Livius Cotarca

Livius Cotarca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof
    Patent number: 8835655
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: September 16, 2014
    Assignee: Zach System S.p.A
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • PROCESS FOR PREPARING 17-SUBSTITUTED STEROIDS
    Publication number: 20140256932
    Abstract: The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.
    Type: Application
    Filed: October 9, 2012
    Publication date: September 11, 2014
    Applicant: ZACH SYSTEM
    Inventors: Yvon Derrien, Patricia Poirier, Massimiliano Forcato, Tony Pintus, Livius Cotarca, Sebastien Meunier, Laurence Graindorge
  • METHOD OF DETECTING POLYMORPHS USING SYNCHROTRON RADIATION
    Publication number: 20140185767
    Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 3, 2014
    Applicant: Zach System S.P.A.
    Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotta, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
  • Process for preparing cinacalcet
    Patent number: 8637708
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: January 28, 2014
    Assignee: Zach System S.p.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Methods of preparing polymorphic form A of bazedoxifene acetate
    Patent number: 8618284
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: December 31, 2013
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • ASYMMETRIC REDUCTION PROCESS
    Publication number: 20130338377
    Abstract: The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 19, 2013
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Mauro Andretto, Livius Cotarca, Antonio Nardi, Massimo Verzini
  • PROCESS FOR PREPARING BOSENTAN MONOHYDRATE AND ITS INTERMEDIATED
    Publication number: 20130253195
    Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
    Type: Application
    Filed: September 22, 2011
    Publication date: September 26, 2013
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
  • METHODS OF PREPARING POLYMORPHIC FORM A OF BAZEDOXIFENE ACETATE
    Publication number: 20130018184
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Application
    Filed: April 23, 2012
    Publication date: January 17, 2013
    Applicant: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • PROCESS FOR PREPARING CINACALCET
    Publication number: 20120238778
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.
    Type: Application
    Filed: September 8, 2010
    Publication date: September 20, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Process for preparing nebivolol
    Patent number: 8258323
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 4, 2012
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Methods of preparing polymorphic form A of bazedoxifene acetate
    Patent number: 8183367
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: May 22, 2012
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • Process for preparing dorzolamide
    Patent number: 8183391
    Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: May 22, 2012
    Assignee: Zach Systems S.p.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Livius Cotarca
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20120108826
    Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.
    Type: Application
    Filed: July 23, 2010
    Publication date: May 3, 2012
    Applicant: ZACH SYSTEM SPA
    Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
  • Process for preparing gabapentin
    Patent number: 8143443
    Abstract: A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-cyclohexaneacetaldehyde with a suitable acetalizing agent to give the corresponding acetal and converting the latter into gabapentin.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: March 27, 2012
    Assignee: ZaCh System S.p.A.
    Inventors: Franco Ghelfi, Livius Cotarca, Fabrizio Roncaglia, Roberto Giovanetti, Andrea Nicoli
  • PROCESS FOR PREPARING OLOPATADINE AND/OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
    Publication number: 20120016138
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Application
    Filed: February 1, 2010
    Publication date: January 19, 2012
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • Process for preparing nebivolol
    Patent number: 8084629
    Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: December 27, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
  • PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE
    Publication number: 20110306794
    Abstract: A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 15, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Nicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
  • Polymorphic Form D of bazedoxifene acetate and methods of preparing same
    Patent number: 8063041
    Abstract: The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: November 22, 2011
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Roberto Brescello, Ivan Michieletto, Mauro Maffini, Nicola Catozzi, Andrea Nicoli, Paolo Fornasari, Massimo Verzini, Livius Cotarca, Franco Brazzarola
  • PROCESS FOR PREPARING NEBIVOLOL
    Publication number: 20110207948
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.
    Type: Application
    Filed: October 28, 2009
    Publication date: August 25, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
  • Process for preparing Nebivolol
    Patent number: 8003810
    Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 23, 2011
    Assignee: Zach System S.p.A.
    Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto