Abstract: A polypeptide-coupled small molecule compound and its antiviral applications are provided. The polypeptide-coupled small molecule compound is obtained by linking a polypeptide with a sequence X?nLXGG and a small molecule compound capable of inhibiting activity of papain-like protease (PLpro) of coronavirus through a chemical bond. The polypeptide with the sequence X?nLXGG is a polypeptide with a sequence LXGG at its carboxyl terminal, X and X? are independently any amino acid, and n is an integer between 1-50. The structure of the small molecule compound capable of inhibiting the activity of PLpro contains an amino group or a hydroxyl group. The polypeptide-coupled small molecule compound can inhibit the PLpro of SARS-CoV-2 in a targeted manner, thereby inhibiting the polyprotein cleavage of coronavirus in the host, and achieving the purpose of inhibiting the replication of coronavirus in the host. It has the advantages of synergistic inhibition, low cytotoxicity and favorable solubility.

Abstract: The present disclosure provides methods, compounds and compositions that are relevant to DNA-repair and DNA-repair proteins such as tyrosyl-DNA phosphodiesterase 1 (TDP1) and type I topoisomerase (TOP1).

Abstract: A polypeptide-coupled small molecule compound and its antiviral applications are provided. The polypeptide-coupled small molecule compound is obtained by linking a polypeptide with a sequence X?nLXGG and a small molecule compound capable of inhibiting activity of papain-like protease (PLpro) of coronavirus through a chemical bond. The polypeptide with the sequence X?nLXGG is a polypeptide with a sequence LXGG at its carboxyl terminal, X and X? are independently any amino acid, and n is an integer between 1-50. The structure of the small molecule compound capable of inhibiting the activity of PLpro contains an amino group or a hydroxyl group. The polypeptide-coupled small molecule compound can inhibit the PLpro of SARS-CoV-2 in a targeted manner, thereby inhibiting the polyprotein cleavage of coronavirus in the host, and achieving the purpose of inhibiting the replication of coronavirus in the host. It has the advantages of synergistic inhibition, low cytotoxicity and favorable solubility.

Abstract: Provided are a carbon composite and a preparation method thereof. The preparation method includes: distilling a bio-tar to obtain a distilled substrate; mixing the distilled substrate and a biochar material to obtain a polymerization starting material; polymerizing the polymerization starting material to obtain a polymer; and mixing the polymer with an activator to obtain a mixture and subjecting the mixture to activation to obtain the carbon composite; wherein the distilling is conducted at a temperature of 120° C. to 150° C.; the activator includes sodium bicarbonate, and a mass ratio of the polymer to the activator is in a range of 1:1 to 1:4; and the activation is conducted at an activation temperature of 700° C. to 800° C. in an anoxic atmosphere for 1 h to 2 h, and the activation temperature is obtained by heating at a speed of 5° C./min to 10° C./min.

Abstract: A horizontal five-axis turning plate type machining center includes a support base, a lathe bed arranged on the support base and a column arranged on the support base, wherein the lathe bed and the column are fixedly connected through a connecting arm, a turning plate device is arranged on the support base, an X-direction sliding plate capable of sliding in an X direction on the lathe bed is arranged on a side, facing the column, of the lathe bed, and a third driving unit capable of driving a workbench to perform position conversion between a turning plate and the X-direction sliding plate is arranged on the turning plate.

Abstract: The present disclosure provides illumination field non-uniformity detection system, detection method, correction method, and device provided.

Abstract: Provided are a carbon composite and a preparation method thereof. The preparation method includes: distilling a bio-tar to obtain a distilled substrate; mixing the distilled substrate and a biochar material to obtain a polymerization starting material; polymerizing the polymerization starting material to obtain a polymer; and mixing the polymer with an activator to obtain a mixture and subjecting the mixture to activation to obtain the carbon composite; wherein the distilling is conducted at a temperature of 120° C. to 150° C.; the activator includes sodium bicarbonate, and a mass ratio of the polymer to the activator is in a range of 1:1 to 1:4; and the activation is conducted at an activation temperature of 700° C. to 800° C. in an anoxic atmosphere for 1 h to 2 h, and the activation temperature is obtained by heating at a speed of 5° C./min to 10° C./min.

Abstract: Disclosed are a wafer-level packaging method for a semiconductor and a semiconductor package. The wafer-level packaging method for the semiconductor comprises: providing a first wafer having one or more memory chip units, each memory chip unit having a storage array circuit and a peripheral circuit, a first scribe line being provided between adjacent memory chip units; providing a second wafer having one or more logic chip units, an area of each logic chip unit corresponding to an area of N memory chip units, N being a natural number greater than or equal to one, a second scribe line being provided between adjacent logic chip units, the second scribe line matching the first scribe line at the periphery of the N memory chip units; and bonding the first wafer to the second wafer to enable the logic chip units to match with the N memory chip units correspondingly. The wafer-level packaging method for the semiconductor expands the application range of a package of a memory wafer.

Abstract: Provided are a three-dimensional carbon-based copolymerization composite, and a preparation method and use thereof.

Abstract: The present disclosure provides a method for two-phase partitioning production of a medium-chain fatty acid (MCFA) by dry anaerobic digestion. In the present disclosure, due to a slow heat transfer of the dry anaerobic digestion, a same dry anaerobic digestion device is naturally divided into two phases, and the MCFA is synthesized while producing electron acceptors and electron donors in the same dry anaerobic digestion device. Meanwhile, the dry anaerobic digestion device is provided with a high-efficiency decomposing microbial inoculant on an upper part and inoculated with sludge having a carbon chain extension function on a lower part. In this way, a material residence time is regulated, and cycles of hydrolytic acidification and carbon chain extension are shortened, thereby achieving the high-value conversion of agricultural waste while increasing a conversion rate of organic acids in the dry anaerobic digestion.

Abstract: Provided are a three-dimensional carbon-based copolymerization composite, and a preparation method and use thereof.

Abstract: The present disclosure provides a method for two-phase partitioning production of a medium-chain fatty acid (MCFA) by dry anaerobic digestion. In the present disclosure, due to a slow heat transfer of the dry anaerobic digestion, a same dry anaerobic digestion device is naturally divided into two phases, and the MCFA is synthesized while producing electron acceptors and electron donors in the same dry anaerobic digestion device. Meanwhile, the dry anaerobic digestion device is provided with a high-efficiency decomposing microbial inoculant on an upper part and inoculated with sludge having a carbon chain extension function on a lower part. In this way, a material residence time is regulated, and cycles of hydrolytic acidification and carbon chain extension are shortened, thereby achieving the high-value conversion of agricultural waste while increasing a conversion rate of organic acids in the dry anaerobic digestion.

Abstract: A rapid mining method for sandstone-type uranium resources in a uranium and coal superposed area, which relates to the technical field of mining engineering is provided. The method includes: arranging a high-density adjustable well pattern in an in-situ leaching mining area; determining a length and a position of a filter located on the in-situ leaching mining area through a digital well construction technology; and in a production stage, carrying out operations such as pumping/injection centralized filtration, intensified leaching, high-intensity extraction, high-intensity injection, and change of layout of the high-density adjustable well pattern to rapidly obtain sandstone-type uranium resources in a uranium and coal superposed area. A recovery speed of the sandstone-type uranium resources can be improved, and service life of the in-situ leaching mining area can be shortened.

Abstract: The present disclosure provides a method for two-phase partitioning production of a medium-chain fatty acid (MCFA) by dry anaerobic digestion. In the present disclosure, due to a slow heat transfer of the dry anaerobic digestion, a same dry anaerobic digestion device is naturally divided into two phases, and the MCFA is synthesized while producing electron acceptors and electron donors in the same dry anaerobic digestion device. Meanwhile, the dry anaerobic digestion device is provided with a high-efficiency decomposing microbial inoculant on an upper part and inoculated with sludge having a carbon chain extension function on a lower part. In this way, a material residence time is regulated, and cycles of hydrolytic acidification and carbon chain extension are shortened, thereby achieving the high-value conversion of agricultural waste while increasing a conversion rate of organic acids in the dry anaerobic digestion.

Abstract: The present disclosure relates to a method and a system for determining a well spacing for in-situ leaching mining of a high-permeability sandstone-type uranium/copper deposit.

Abstract: The invention provides a method of pyrolysis carbonization and catalysis for biomass, which comprises: using waste biomass from agriculture and forestry as raw materials, conducting pyrolysis carbonization reaction at 630˜720° C. under oxygen-limited or oxygen-insulation conditions, obtaining biochar and bio-tar-containing pyrolysis oil-gas mixture after gas-solid separation of the products; treating the bio-tar-containing pyrolysis oil-gas mixture obtained with a biochar catalyst at 690˜850° C., carrying out bio-tar catalytic cracking to obtain small molecular combustible gas and light bio-tar, preserving heat and ageing the biochar obtained at 530˜650° C. then making a kind of biochar catalyst. The invention further provides an integrated device used for the method of pyrolysis carbonization and catalysis for biomass, comprising: a spiral feeder, a pyrolysis carbonization device and a catalysis device.

Abstract: A horizontal five-axis turning plate type machining center includes a support base, a lathe bed arranged on the support base and a column arranged on the support base, wherein the lathe bed and the column are fixedly connected through a connecting arm, a turning plate device is arranged on the support base, an X-direction sliding plate capable of sliding in an X direction on the lathe bed is arranged on a side, facing the column, of the lathe bed, and a third driving unit capable of driving a workbench to perform position conversion between a turning plate and the X-direction sliding plate is arranged on the turning plate.

Abstract: A method for forming a backside illuminated image sensor with a three-dimensional transistor structure is provided, where forming a gate of the three-dimensional transistor structure includes: forming a source follower transistor and/or a reset transistor with a three-dimensional transistor structure, wherein the source follower transistor and/or the reset transistor correspond to a protruding structure; and forming an insulating sidewall around the protruding structure, forming a groove between the insulating sidewall and a channel region of a transistor corresponding to the protruding structure, and forming a gate of the transistor in the groove, wherein the gate of the transistor is isolated by the insulating sidewall.

Abstract: A method for forming a backside illuminated image sensor with a three-dimensional transistor structure is provided, where forming a gate of the three-dimensional transistor structure includes: forming a source follower transistor and/or a reset transistor with a three-dimensional transistor structure, wherein the source follower transistor and/or the reset transistor correspond to a protruding structure; and forming an insulating sidewall around the protruding structure, forming a groove between the insulating sidewall and a channel region of a transistor corresponding to the protruding structure, and forming a gate of the transistor in the groove, wherein the gate of the transistor is isolated by the insulating sidewall.

Abstract: The present invention discloses a CMOS image sensor structure and packaging method thereof. The method includes the following steps: providing an image sensor chip and a transparent package substrate that is ground and cut, the front side of the image sensor chip being provided with an image sensing region and a pad region surrounding the image sensing region; bonding a first end of a metal wire onto the pad, the other end being suspended outside the image sensor chip; bonding the transparent package substrate and the image sensor chip having the metal wire to form an image sensor package, which can be assembled by surface mount technology (SMT) or pressure welding via the exposed and suspended metal wire. In the present invention, an auxiliary substrate is optionally used and an optical glass is directly fixed to the image sensor chip, and the image sensor chip is directly connected to a circuit board.