Patents by Inventor Long Liu

Long Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12670375
    Abstract: Provided are a reconfigurable neuron device based on ion gate regulation and a method of preparing the same. The device includes: a synthetic antiferromagnetic layer, a metal oxide layer, an ionic liquid layer and a top electrode layer which are sequentially stacked from bottom to top. A left boundary antiferromagnetic layer and a right boundary antiferromagnetic layer having opposite magnetization directions are provided on two opposite edges of a bottom end of the synthetic antiferromagnetic layer, and a magnetic tunnel junction configured to output a spike signal is further provided in a middle portion of the bottom end of the synthetic antiferromagnetic layer. The metal oxide layer, the ionic liquid layer and the top electrode layer constitute an ion gate, the ionic liquid layer includes a positive ion and a negative ion.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: June 30, 2026
    Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Xuefeng Zhao, Guozhong Xing, Di Wang, Ziwei Wang, Long Liu, Huai Lin, Hao Zhang
  • Publication number: 20260181911
    Abstract: A neuron device based on magnetic tunnel junction and a neural network apparatus are provided, where the neuron device based on magnetic tunnel junction includes: a synthetic antiferromagnetic layer, where a first side of the synthetic antiferromagnetic layer is provided with a bottom electrode; a barrier layer arranged on a second side of the synthetic antiferromagnetic layer; a ferromagnetic free layer arranged on a side of the barrier layer away from the bottom electrode; a top electrode arranged on a side of the ferromagnetic free layer away from the bottom electrode; a first boundary antiferromagnetic pinning layer and a second boundary antiferromagnetic pinning layer both arranged on the side of the ferromagnetic free layer away from the bottom electrode, and respectively located on two sides of the top electrode.
    Type: Application
    Filed: May 11, 2022
    Publication date: June 25, 2026
    Inventors: Guozhong XING, Ziwei WANG, Xuefeng ZHAO, Di Wang, Long LIU, Huai LIN, Hao Zhang
  • Publication number: 20260117169
    Abstract: The present invention provides a method for forming a reversible membraneless organelle in microorganisms. In the present invention, in order to form a membraneless organelle in a host cell, an artificial short peptide sequence WGR-1 is fused on the basis of an intrinsically disordered protein RGG. Fusion of one WGR-1 sequence or two WGR-1 sequences connected in series can both effectively promote phase separation of RGG, thus forming a membraneless organelle in Saccharomyces cerevisiae, wherein the membraneless organelle RGG-(WGR-1)2 has a better liquid fluidity. RGG-x-(WGR-1)2 is further constructed by introducing an enzyme cleavage site x into the RGG-(WGR-1)2 system in the present invention, and the reversible formation of the membraneless organelle is achieved after expression of a protease is induced. The method of the present invention has important value in customizing and controlling cell functions and the like.
    Type: Application
    Filed: December 30, 2024
    Publication date: April 30, 2026
    Inventors: Long LIU, Jian CHEN, Xueqin LV, Guocheng DU, Ke JIN, Ziyang HUANG
  • Patent number: 12612595
    Abstract: The present invention provides a method for forming a reversible membraneless organelle in microorganisms. In the present invention, in order to form a membraneless organelle in a host cell, an artificial short peptide sequence WGR-1 is fused on the basis of an intrinsically disordered protein RGG. Fusion of one WGR-1 sequence or two WGR-1 sequences connected in series can both effectively promote phase separation of RGG, thus forming a membraneless organelle in Saccharomyces cerevisiae, wherein the membraneless organelle RGG-(WGR-1)2 has a better liquid fluidity. RGG-x-(WGR-1)2 is further constructed by introducing an enzyme cleavage site x into the RGG-(WGR-1)2 system in the present invention, and the reversible formation of the membraneless organelle is achieved after expression of a protease is induced. The method of the present invention has important value in customizing and controlling cell functions and the like.
    Type: Grant
    Filed: December 30, 2024
    Date of Patent: April 28, 2026
    Assignees: JITRI FUTURE FOOD TECHNOLOGY INSITUTE CO., LTD., JIANGNAN UNIVERSITY
    Inventors: Long Liu, Jian Chen, Xueqin Lv, Guocheng Du, Ke Jin, Ziyang Huang
  • Patent number: 12588423
    Abstract: The present disclosure relates to a field of memory technical, and in particular to a magnetoresistive device, a method for changing a resistance state of the magnetoresistive device, and a synapse learning module. The magnetoresistive device includes a top electrode, a ferromagnetic reference layer, a tunneling layer, a ferromagnetic free layer, a spin-orbit coupling layer, and a bottom electrode that are arranged in sequence along a preset direction, where the spin-orbit coupling layer includes a first thickness region and a second thickness region distributed alternately, and a thickness of the first thickness region is different form a thickness of the second thickness region; and the ferromagnetic free layer includes a pinning region, and a position of the pinning region is in one-to-one correspondence with a position of the first thickness region.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: March 24, 2026
    Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Guozhong Xing, Di Wang, Huai Lin, Long Liu, Yu Liu, Hangbing Lv, Changqing Xie, Ling Li, Ming Liu
  • Patent number: 12550276
    Abstract: A connector for a case shell of a power apparatus includes a main body member. Two ends of the main body member are respectively connected to different members of the case shell, and the main body member is deformable; and the main body member is used to deform when an explosion occurs inside the case shell and the different members of the case shell connected by means of the main body member are disengaged from each other. The main body member of the connector can deform when devices inside the case shell explode and the different members of the case shell connected by means of the main body member are disengaged from each other, such that two members of the case shell connected by means of the main body member are slightly disengaged from each other to form a gap.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: February 10, 2026
    Assignee: Sungrow Power Supply Co., Ltd.
    Inventors: Long Liu, Xiangyang Ren, Wenhao Li, Yonghong Li
  • Patent number: 12524659
    Abstract: A neuron device including: an antiferromagnetic pinning layer, a first ferromagnetic layer and a spin orbit coupling layer formed on a substrate in sequence; a free layer formed on the spin orbit coupling layer and moving a magnetic domain wall according to a spin orbit torque; a tunneling layer formed on the free layer; a left pinning layer and a right pinning layer formed on two sides of the free layer and having opposite magnetization directions; and a reference layer formed on the tunneling layer; wherein the free layer, the tunneling layer and the reference layer constitute a magnetic tunnel junction, and the magnetic tunnel junction is configured to read neuronal signals. Also provided is a method for preparing a neuron device based on a spin orbit torque.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: January 13, 2026
    Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Guozhong Xing, Di Wang, Huai Lin, Long Liu, Ming Liu
  • Patent number: 12525271
    Abstract: A multi-resistance-state spintronic device, including: a top electrode and a bottom electrode respectively connected to a read-write circuit; and a magnetic tunnel junction between two electrodes. The magnetic tunnel junction includes from top to bottom: a ferromagnetic reference layer, a barrier tunneling layer, a ferromagnetic free layer, and a spin-orbit coupling layer. Nucleation centers are provided at two ends of the ferromagnetic free layer to generate a magnetic domain wall; the spin-orbit coupling layer is connected to the bottom electrode, and when a write pulse is applied, an electron spin current is generated and drives the magnetic domain wall through a spin-orbit torque to move; a plurality of local magnetic domain wall pinning centers are provided at an interface between the spin-orbit coupling layer and the ferromagnetic free layer to enhance a strength of a DM interaction constant between interfaces.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: January 13, 2026
    Assignee: Institute of Microelectronics, Chinese Academy of Sciences
    Inventors: Guozhong Xing, Huai Lin, Feng Zhang, Di Wang, Long Liu, Changqing Xie, Ling Li, Ming Liu
  • Patent number: 12460853
    Abstract: An ice making method for a refrigerator and a refrigerator. The ice making method for a refrigerator comprises: enabling the temperature in an ice making compartment to be higher than or equal to a first preset value; filling an ice making container in the ice making compartment with water; providing cold energy to the ice making compartment according to a first refrigeration capacity, enabling the temperature in the ice making compartment to sequentially drop to reach multiple first preset temperatures, and when the temperature in the ice making compartment drops to reach each first preset temperature, maintaining the temperature in the ice making compartment at the first preset temperature for a corresponding first preset duration, among two adjacent first preset temperatures, the first preset duration corresponding to the lower first preset temperature being shorter than the first preset duration corresponding to the higher first preset temperature.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: November 4, 2025
    Assignees: QINGDAO HAIER REFRIGERATOR CO., LTD., HAIER SMART HOME CO., LTD.
    Inventors: Long Liu, Ming Wang, Bintang Zhao
  • Patent number: 12389338
    Abstract: A transmission power allocation method is provided. The transmission power allocation method is applied in user equipment (UE). The transmission power allocation method includes the following steps. The UE calculates the target power. The UE calculates the path loss of each antenna of the UE. The UE adjusts the transmission power of each antenna, except for a first antenna which corresponds to the maximum path loss, based on the maximum path loss.
    Type: Grant
    Filed: October 28, 2022
    Date of Patent: August 12, 2025
    Assignee: MEDIATEK SINGAPORE PTE. LTD.
    Inventors: Zhen Song, Long Liu, Yan Wu, Wei Tang
  • Patent number: 12387774
    Abstract: Provided is a spintronic device, a memory cell, a memory array, and a read and write circuit applied in a field of integration technology. The spintronic device includes: a bottom electrode; a spin orbit coupling layer, arranged on the bottom electrode; at least one pair of magnetic tunnel junctions, arranged on the spin orbit coupling layer, wherein each of the magnetic tunnel junctions includes a free layer, a tunneling layer, and a reference layer arranged sequentially from bottom to top, and wherein magnetization directions of reference layers of two magnetic tunnel junctions of each pair of the magnetic tunnel junctions are opposite; and a top electrode, arranged on a reference layer of each of the magnetic tunnel junctions.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: August 12, 2025
    Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Guozhong Xing, Di Wang, Long Liu, Huai Lin, Ming Liu
  • Patent number: 12365926
    Abstract: The invention provides a Saccharomyces cerevisiae strain for producing a human milk lipid substitute. By integrating a heterologous lysophosphatidic acid acyltransferase into Saccharomyces cerevisiae and knocking out its own natural lysophosphatidic acid acyltransferase, the content of palmitic acid (C16:0) at Sn-2 position of triacylglycerol produced by Saccharomyces cerevisiae is increased, to synthesize a human milk lipid substitute. On this basis, a metabolic pathway related gene is knocked out, to further increase the content of human milk lipid substitute in the product. In the present invention, a human milk lipid substitute is de novo synthesized by Saccharomyces cerevisiae for the first time, in which the total fatty acid is 15% or more, and the relative content of C16:0 at Sn-2 position reaches about 60%.
    Type: Grant
    Filed: November 1, 2023
    Date of Patent: July 22, 2025
    Assignees: JIANGNAN UNIVERSITY, INNER MONGOLIA MENGNIU DAIRY (GROUP) COMPANY LIMITED
    Inventors: Long Liu, Jian Chen, Xueqin Lv, Wenyang Wu, Guocheng Du, Jianghua Li, Guolin Zhou, Yanfeng Liu, Chenyang Zhang
  • Publication number: 20250215193
    Abstract: The present disclosure relates to the technical field of organic polymer compounds, in particular to chromatography media for removal of polyphenol substances and a preparation method thereof. A method for preparing chromatography media for the removal of polyphenol substances includes: obtaining an aqueous phase by mixing a water-soluble inorganic salt, a dispersing agent and water; obtaining an oil phase by mixing N-vinyl pyrrolidone, a first crosslinking agent, a second crosslinking agent, a third crosslinking agent, an initiator and a pore-forming agent; and preparing the chromatography media for the removal of the polyphenol substances by adding the oil phase into the aqueous phase for suspension polymerization. The chromatography media of the present disclosure has an effective binding ability for the polyphenol substances in fermented beverages, and an adsorption rate of the polyphenol substances is in a range from 40% to 46%.
    Type: Application
    Filed: December 4, 2024
    Publication date: July 3, 2025
    Applicant: SUNRESIN NEW MATERIALS CO. LTD.
    Inventors: Chenhui LI, Yanjun LI, Long LIU, Kai WANG, Mingxi WANG
  • Publication number: 20250204264
    Abstract: The present disclosure provides a skyrmion transistor and a method of controlling a skyrmion transistor. The transistor includes: a ferromagnetic nanotube; a writing magnetic tunnel junction and a reading magnetic tunnel junction surrounding both ends of the ferromagnetic nanotube respectively; and a ferroelectric ring surrounding an outer side of the ferromagnetic nanotube and located between the writing magnetic tunnel junction and the reading magnetic tunnel junction, where the ferromagnetic nanotube and the ferroelectric ring form a ferromagnetic/ferroelectric heterojunction.
    Type: Application
    Filed: April 20, 2022
    Publication date: June 19, 2025
    Inventors: Guozhong XING, Hao ZHANG, Xuefeng ZHAO, Long LIU, Di WANG, Huai LIN, Ziwei WANG
  • Publication number: 20250188134
    Abstract: The present invention relates to the technical field of protein biological functions, in particular to a polypeptide, a fusion type multimeric protein and use thereof, the polypeptide is selected from: (1), a polypeptide having a substitution mutation in at least one position selected from the group consisting of positions 16, 25, 29, 49 and 58, as compared with a natural C structural domain of a protein A as shown in SEQ ID NO.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 12, 2025
    Inventors: Yanjun LI, Gang LI, Tongnian GU, Jiantao ZHANG, Long LIU, Xiaoju LEI, Qiong LIU
  • Patent number: 12293781
    Abstract: The three-state spintronic device includes: a bottom electrode, a magnetic tunnel junction and a top electrode from bottom to top. The magnetic tunnel junction includes: a spin-orbit coupling layer, a ferromagnetic free layer, a barrier tunneling layer, a ferromagnetic reference layer, three local magnetic domain wall pinning centers and domain wall nucleation centers. An antisymmetric exchange interaction is modulated, and the magnetic domain wall pinning centers are embedded in an interface between a heavy metal and the ferromagnetic free layer. The magnetic domain wall nucleation centers are at two ends of the ferromagnetic free layer. A current pulse flows through the spin-orbit coupling layer to generate a spin current and the spin current is injected into the ferromagnetic free layer. Under a control of all-electrical controlled, an effective field of a spin-orbit torque drives domain wall to move and displace.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: May 6, 2025
    Assignee: INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Huai Lin, Guozhong Xing, Zuheng Wu, Long Liu, Di Wang, Cheng Lu, Peiwen Zhang, Changqing Xie, Ling Li, Ming Liu
  • Patent number: 12275763
    Abstract: The present invention discloses a RamA transcription factor mutant for promoting the production of N-acetylglucosamine and use thereof. The mutant is obtained by mutating lysine at position 90 to asparagine and serine at position 92 to lysine in a parent having an amino acid sequence as shown in SEQ ID NO: 2. The present invention provides a genetically engineered strain that overexpresses the RamA transcription factor mutant and increases the production of N-acetylglucosamine. By overexpressing the transcription factor RamA that is involved in the regulation of carbon metabolism, the extracellular accumulation of N-acetylglucosamine is increased, with a maximum concentration reaching 31.5 g/L, which lays a foundation for further metabolic engineering of Corynebacterium glutamicum to produce glucosamine. The method for constructing recombinant Corynebacterium glutamicum of the invention is simple, and convenient in use, and thus has good application prospects.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 15, 2025
    Assignees: JIANGNAN UNIVERSITY, SHANDONG RUNDE BIOTECHNOLOGY CO., LTD.
    Inventors: Long Liu, Jian Chen, Xueqin Lv, Jianxing Lu, Changfeng Liu, Guocheng Du, Jianghua Li, Chen Deng, Jiangong Lu
  • Publication number: 20250060140
    Abstract: An ice making method for a refrigerator and a refrigerator. The ice making method for a refrigerator comprises: enabling the temperature in an ice making compartment to be higher than or equal to a first preset value; filling an ice making container in the ice making compartment with water; providing cold energy to the ice making compartment according to a first refrigeration capacity, enabling the temperature in the ice making compartment to sequentially drop to reach multiple first preset temperatures, and when the temperature in the ice making compartment drops to reach each first preset temperature, maintaining the temperature in the ice making compartment at the first preset temperature for a corresponding first preset duration, among two adjacent first preset temperatures, the first preset duration corresponding to the lower first preset temperature being shorter than the first preset duration corresponding to the higher first preset temperature.
    Type: Application
    Filed: April 28, 2022
    Publication date: February 20, 2025
    Inventors: Long LIU, Ming WANG, Bintang ZHAO
  • Patent number: 12221640
    Abstract: The present invention provides a method for promoting N-acetylglucosamine synthesis by using the GlcN6P responsive element. In the present invention, Bacillus subtilis BSGNY-Pveg-glmS-P43-GNA1 is used as a starting strain, in which a CRISPRi system regulated by GlcN6P responsive element is integrated into the genome to dynamically weaken the N-acetylglucosamine synthesis competitive pathway; a GlcN6P responsive promoter is used to regulate the expression of GNA1 on the plasmid to dynamically regulate the N-acetylglucosamine synthesis pathway; and the key gene alsSD involved in the acetoin synthesis pathway is knocked out. During fed-batch fermentation with this strain in a 15 L fermenter, the production of N-acetylglucosamine reaches 131.6 g/L and no by-product acetoin is accumulated, which lays a foundation for the production of GlcNAc by industrial fermentation.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 11, 2025
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Long Liu, Jian Chen, Guocheng Du, Yaokang Wu, Taichi Chen, Jianghua Li
  • Patent number: 12209549
    Abstract: Disclosed is a combustion system design method based on a target heat release rate, which belongs to the technical field of diesel engine combustion chamber design. The method includes: obtaining an ideal heat release rate based on Sabathe-Miller cycle; simulating the ideal heat release rate based on a double-Wiebe function and obtaining the target heat release rate; constructing a mapping relation among the heat release rate, piston geometric parameters and fuel injection parameters, which includes target start of combustion being an function of fuel injection timing and ignition delay, premixed combustion parameters being functions of throat radius, injection pressure and nozzle diameter, and diffusion combustion being a function of piston pit depth; solving target piston geometric parameters and target fuel injection parameters based on the mapping relation; and then designing a combustion system.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: January 28, 2025
    Assignee: Harbin Engineering University
    Inventors: Long Liu, Yan Peng, Changfu Han, Haicheng Qi, Li Huang, Wenzheng Zhang