Patents by Inventor Longbin Liu

Longbin Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HTT modulators for treating Huntington's disease
    Patent number: 12281116
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: April 22, 2025
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Celia Dominguez, Nikolay V. Plotnikov, Alan Haughan, Andrew Stott, Brett Cosgrove, Cole Clissold, Huw Vater, Jonathan Spencer, William Esmieu, Karine Malagu, Mark Chambers
  • HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20240342317
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Application
    Filed: January 2, 2024
    Publication date: October 17, 2024
    Inventors: Longbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Catherine Jane Greenaway, Kanika Khurana, Matthew Robert Mills, Filippo Rota
  • Compounds for targeting mutant huntingtin protein and uses thereof
    Patent number: 12083108
    Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: September 10, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Jonathan Bard, Matthew R. Lee, Longbin Liu, Michael Edward Prime, Samuel Coe
  • Substituted piperazines as KRAS G12C inhibitors
    Patent number: 12083121
    Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: September 10, 2024
    Assignee: Amgen Inc.
    Inventors: John Gordon Allen, Brian Alan Lanman, Jian Chen, Anthony B. Reed, Victor J. Cee, Longbin Liu, Patricia Lopez, Ryan Paul Wurz, Thomas T. Nguyen, Shon Booker, Jennifer Rebecca Allen, Margaret Chu-Moyer, Albert Amegadzie, Ning Chen, Clifford Goodman, Jonathan D. Low, Vu Van Ma, Ana Elena Minatti, Nobuko Nishimura, Alexander J. Pickrell, Hui-Ling Wang, Youngsook Shin, Aaron C. Siegmund, Kevin C. Yang, Nuria A. Tamayo, Mary Walton, Qiufen Xue
  • Heterobiaryl compounds and imaging agents for imaging huntingtin protein
    Patent number: 12036292
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: July 16, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Celia Dominguez, Xuemei Chen, John E. Mangette
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20240174660
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: December 18, 2023
    Publication date: May 30, 2024
    Inventors: Brian Alan LANMAN, Jian CHEN, Anthony B. REED, Victor J. CEE, Longbin LIU, David John KOPECKY, Patricia LOPEZ, Ryan Paul WURZ, Thomas T. NGUYEN, Shon BOOKER, Nobuko NISHIMURA, Youngsook SHIN, Nuria A. TAMAYO, John Gordon ALLEN, Jennifer Rebecca ALLEN
  • Compounds and probes for imaging huntingtin protein
    Patent number: 11992535
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 28, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Christopher John Brown, Sarah Hayes, Adrian Kotey, Matthew Robert Mills, Michael Edward Prime
  • Heterocyclic compounds and imaging agents for imaging huntingtin protein
    Patent number: 11918662
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: March 5, 2024
    Assignee: CHDI Foundation, Inc.
    Inventors: Longbin Liu, Matthew Lee, Celia Dominguez, Peter David Johnson, Catherine Jane Greenaway, Kanika Khurana, Matthew Robert Mills, Filippo Rota
  • KRAS G12C inhibitors and methods of using the same
    Patent number: 11905281
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: February 20, 2024
    Assignee: Amgen Inc.
    Inventors: Brian Alan Lanman, Jian Chen, Anthony B. Reed, Victor J. Cee, Longbin Liu, David John Kopecky, Patricia Lopez, Ryan Paul Wurz, Thomas T. Nguyen, Shon Booker, Nobuko Nishimura, Youngsook Shin, Nuria A. Tamayo, John Gordon Allen, Jennifer Rebecca Allen
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20240050430
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: June 23, 2023
    Publication date: February 15, 2024
    Inventors: John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert AMEGADZIE, Nuria A. TAMAYO, Shon BOOKER, Clifford GOODMAN, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan D. LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN
  • HTT modulators for treating Huntington's disease
    Patent number: 11806346
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: November 7, 2023
    Assignee: CHDI Foundation, Inc.
    Inventors: Celia Dominguez, Elizabeth M. Doherty, Longbin Liu, Matthew Lee, Mark Stuart Chambers, Karine Fabienne Malagu, Perla Breccia, Alan F. Haughan, Huw D. Vater, Andrew J. Stott, William R. K. Esmieu, Stephen John Webster, Amanda J. Van De Poël
  • KRAS G12C inhibitors and methods of using the same
    Patent number: 11766436
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: September 26, 2023
    Assignee: Amgen Inc.
    Inventors: John Gordon Allen, Jennifer Rebecca Allen, Ana Elena Minatti, Qiufen Xue, Ryan Paul Wurz, Christopher M. Tegley, Alexander J. Pickrell, Thomas T. Nguyen, Vu Van Ma, Patricia Lopez, Longbin Liu, David John Kopecky, Michael J. Frohn, Ning Chen, Jian Jeffrey Chen, Aaron C. Siegmund, Albert Amegadzie, Nuria A. Tamayo, Shon Booker, Clifford Goodman, Mary Walton, Nobuko Nishimura, Youngsook Shin, Jonathan D. Low, Victor J. Cee, Anthony B. Reed, Hui-Ling Wang, Brian Alan Lanman
  • RECOMBINANT HUMAN EPO-FC-FUSION PROTEINS WITH PROLONGED HALF-LIFE AND ENHANCED ERYTHROPOIETIC ACTIVITY IN VIVO
    Publication number: 20230265143
    Abstract: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo.
    Type: Application
    Filed: March 21, 2022
    Publication date: August 24, 2023
    Inventors: Haitao Wang, Yong Du, Rui Zhang, Jing Xu, Longbin Liu
  • HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20230159531
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Application
    Filed: November 16, 2022
    Publication date: May 25, 2023
    Inventors: Longbin Liu, Celia Dominguez, Nikolay V. Plotnikov, Alan Haughan, Andrew Stott, Brett Cosgrove, Cole Clissold, Huw Vater, Jonathan Spencer, William Esmieu, Karine Malagu, Mark Chambers
  • USE OF RECOMBINANT CYTOKINE GENE DERIVED PROTEIN OR FRAGMENT THEREOF
    Publication number: 20230088483
    Abstract: Provided is a use of a recombinant cytokine gene derived protein or a fragment thereof for inhibiting the activity of a Coronaviridae virus. The recombinant cytokine gene derived protein includes an amino acid sequence represented by SEQ ID NO: 1, or an amino acid sequence that is at least 90% identical to the amino acid sequence represented by SEQ ID NO: 1. Also provided is a use of the described recombinant cytokine gene derived protein or a fragment thereof in the preparation of a drug for preventing or treating a disease or symptom related to the Coronaviridae virus in a subject.
    Type: Application
    Filed: February 24, 2021
    Publication date: March 23, 2023
    Inventors: Qiujun LV, Longbin LIU
  • COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF
    Publication number: 20220409600
    Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.
    Type: Application
    Filed: May 24, 2022
    Publication date: December 29, 2022
    Inventors: Celia Dominguez, Jonathan Bard, Matthew R. Lee, Longbin Liu, Michael Edward Prime, Samuel Coe
  • HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20220409615
    Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 29, 2022
    Inventors: Celia Dominguez, Elizabeth M. Doherty, Longbin Liu, Matthew Lee, Mark Stuart Chambers, Karine Fabienne Malagu, Perla Breccia, Alan F. Haughan, Huw D. Vater, Andrew J. Stott, William R. K. Esmieu, Stephen John Webster, Amanda J. Van De Poël
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20220395504
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 15, 2022
    Inventors: John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert AMEGADZIE, Nuria A. TAMAYO, Shon BOOKER, Clifford GOODMAN, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan D. LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN
  • DEUTERATED COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20220372045
    Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Application
    Filed: April 26, 2022
    Publication date: November 24, 2022
    Inventors: Longbin Liu, Celia Dominguez, Jonathan Bard, Vinod Khetarpal, Ashley Jarvis, Sarah Hayes, John E. Mangette
  • ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN
    Publication number: 20220339302
    Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.
    Type: Application
    Filed: April 7, 2022
    Publication date: October 27, 2022
    Inventors: Longbin Liu, Celia Dominguez, Jonathan Bard, Christopher John Brown, Xuemei Chen, Daniel Clark-Frew, Matthew Robert Mills, Peter David Johnson, Elise Gadouleau