Patents by Inventor Louis Lafon

Louis Lafon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5446060
    Abstract: The present invention relates to compounds of formula: ##STR1## in which A is selected from pyrrolidino, piperidino, morpholino, 1-imidazolyl, hexamethylenimino and 1-piperazinyl groups, these groups being unsubstituted or it being possible for them to contain 1 or 2 substituents selected from C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 hydroxyalkyl groups, and the addition salts of these compounds with pharmaceutically acceptable acids.These compounds are usable in therapy as peripheral vasodilators.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: August 29, 1995
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 5391576
    Abstract: The invention relates to a method for protecting the cerebral tissue of a human against the repercussions of ischaemia which comprises administering to a patient in need thereof a therapeutically effective amount of modafinil.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: February 21, 1995
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon, deceased
  • Patent number: 5250543
    Abstract: The invention relates to compounds having the formula: ##STR1## in which Ar represents a group selected from 2-nitrophenyl, 3-nitrophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, 2-trifluoromethylphenyl and 3-trifluoromethylphenyl;R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a group having the formula: ##STR2## A represents a group selected from groups having the formulae: ##STR3## and R.sub.2 represents a group selected from 2,4,6-trimethoxyphenyl, 2-thienyl and phenyl, and their addition salts with pharmaceutically acceptable acids.These compounds are calcium inhibitors with therapeutic applications.
    Type: Grant
    Filed: January 8, 1992
    Date of Patent: October 5, 1993
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 5236922
    Abstract: The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperazino, 4-phenyl-piperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof.These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: August 17, 1993
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 5180745
    Abstract: The present invention relates to a method for providing a patient with neuroprotective effect, which consists in administering modafinil to said patient.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: January 19, 1993
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 5128349
    Abstract: The present invention relates to 1-(4-aminophenyl)-2-piperidinopropanone derivatives which are selected from(a) the compounds corresponding to the general formula ##STR1## where R is H or CH.sub.3 CO, A is H or Cl, B is H or Cl and Z is C.sub.1 -C.sub.4 -alkyl; and(b) their addition salts,These products are used as cardiovascular agents. In particular, the compounds of the formula I where R=H or CH.sub.3 CO, A=B=Cl and Z=CH.sub.3, and their addition salts, are especially very worthwhile as vasodilators.
    Type: Grant
    Filed: October 29, 1990
    Date of Patent: July 7, 1992
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4983599
    Abstract: The present invention relates to 1-(4-aminophenyl-2)-hexamethyleniminopropanone and its pharmaceutically acceptable addition salts.These products are useful in therapy on account of their antidepressant effects on the CNS and their immunological properties.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: January 8, 1991
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4980377
    Abstract: The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperzaino, 4-phenylpiperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof.These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: December 25, 1990
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4963570
    Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichNR.sub.1 R.sub.2 represents a piperidino group; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.sub.3 CONH and Y and Z, which can be identical or different, each represent a hydrogen or halogen atom; and(b) their addition salts.These new products are useful as antidepressants for the central nervous system. The invention also relates to the method for their preparation.
    Type: Grant
    Filed: July 7, 1989
    Date of Patent: October 16, 1990
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4933370
    Abstract: The present invention relates, by way of novel industrial products, to 1-(4-aminophenyl)-2-dimethylaminopropanone derivatives which are selected from:(a) the compounds having the general formula ##STR1## in which R is H or CH.sub.3 CO, and (b) addition salts thereof.These products are useful as antidepressants. Furthermore, 1-(4-acetylamino-3,5-dichlorophenyl)-2-dimethylaminopropanone and non-toxic addition salts thereof are useful as immunostimulants.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: June 12, 1990
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4933442
    Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichR.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.6 cycloalkyl group;R.sub.2 represents the hydrogen atom or a C.sub.1 -C.sub.4 alkyl group;R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, an N-heterocyclic group with 5 to 7 ring members, capable (i) of including a second heteroatom selected from N, O and S, and (ii) of being substituted, the said heterocyclic group NR.sub.1 R.sub.2 being selected from the group comprising pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino, 4-(.beta.-hydroxyethyl) piperazino, 4-phenylpiperazino and 4-(p-chlorophenyl)-piperazino groups; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: June 12, 1990
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4927855
    Abstract: The levorotatory isomer of benzhydrylsulfinylacetamide has useful pharmaceutical activity on the central nervous system, particularly as an antidepressant and stimulant in the treatment of hypersomnia and Alzheimer's disease.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: May 22, 1990
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4912110
    Abstract: The present invention relates, by way of new industrial products, to phenylpiperazine derivatives selected from the group comprising 3-methyl-2-phenylpiperazine, 1-isopropyl-3-phenylpiperazine, 1-ethyl-2-methyl-3-phenylpiperazine, 1-isopropyl-2-methyl-3-phenylpiperazine, 1,2,4-trimethyl-3-phenylpiperazine, and (halogenophenyl)alkyl-piperazines of the formula: ##STR1## (wherein X.sub.o is F, Cl or Br, R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R.sub.2 is H or C.sub.1 -C.sub.2 alkyl and R.sub.3 is H or C.sub.1 -C.sub.4 alkyl, at least one of the symbols R.sub.1, R.sub.2 and R.sub.3 being different from H), and addition salts thereof.These new products are useful as antidepressants for the CNS.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: March 27, 1990
    Assignee: Laboratoire L. Lafton
    Inventor: Louis Lafon
  • Patent number: 4883507
    Abstract: The present invention relates, by way of a novel industrial product, to a filter for gaseous fluid, which contains a lyophilized and compressed filter element in the form of a porous layer.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: November 28, 1989
    Assignee: Laboratoire L. Lafon
    Inventors: Louis Rey, Brynjulf Ottar, Louis Lafon
  • Patent number: 4877812
    Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichR.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.6 cycloalkyl group;R.sub.2 represents the hydrogen atom or a C.sub.1 -C.sub.4 alkyl group;R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, an N-heterocyclic group with 5 to 7 ring members, capable (i) of including a second heteroatom selected from N, O and S, and (ii) of being substituted, the said heterocyclic group NR.sub.1 R.sub.2 being selected from the group comprising pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino, 4-(.beta.-hydroxyethyl) piperazino, 4-phenylpiperazino and 4-(p-chlorophenyl)-piperazino groups; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: October 31, 1989
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4861801
    Abstract: The present invention relates to a process for the treatment of depression comprising administering to a human in need thereof an antidepressant amount of a compound selected from 1-(2-fluorophenyl)-2-tertiobutylamino-1-ethanol and an addition salt thereof.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: August 29, 1989
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4847274
    Abstract: The present invention relates to 4-phenylthiazole derivatives, namely 2-(2-hydroxyethylamino)-4-phenylthiazole and its addition salts.These derivatives act on the CNS and are useful as sedatives.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: July 11, 1989
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4835315
    Abstract: The present invention relates to new compounds belonging to the family of fluorophenacyl-amine derivates of formula: ##STR1## [wherein A is CO or CHOH and R is CH(CH.sub.3).sub.2 or C(CH.sub.3).sub.3 ] and selected from the group consisting of N-(4-fluorophenacyl)-isopropylamine, N-(2-fluorophenacyl)-tertiarybutylamine, 1-(2-fluorophenyl)-2-tertiarybutylamino-1-ethanol, 1-(4-fluorophenyl)-2-tertiarybutylamino-1-ethanol, and their addition salts, These new derivatives are useful in therapeutics, particularly as anti-aggressive agents, anti-anorexia nervosa agents, sedative agents, and CNS- antidepressants.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: May 30, 1989
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4816489
    Abstract: The present invention relates to the preparation of new derivatives selected from the group consisting of:(i) 1-(aminophenyl)-2-(alkylamino)ethanones of the formula: ##STR1## in which R is CH(CH.sub.3).sub.2 or C(CH.sub.3).sub.3 ; and (ii) addition salts thereof.These new derivatives are useful in therapy, in particular as antidepressants or stimulants for the CNS. They are prepared from 1-(acetylaminophenyl)-2-(alkylamino)ethanone derivatives by deacetylation.
    Type: Grant
    Filed: September 10, 1987
    Date of Patent: March 28, 1989
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4774248
    Abstract: The present invention relates to new derivatives selected from the group comprising:(i) the 5-phenylhydropyrimidines of the formula: ##STR1## in which: X.sub.1 and X.sub.2, which are identical or different, each represent H, F, Cl, Br or CF.sub.3, andA represents a polyhydropyrimidinyl group of the structure: ##STR2## in which: Y represents H or OH,R.sub.a represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.5 alkanoyl group, it being possible for R.sub.a to represent the hydrogen atom when at least one of the groups X.sub.1, X.sub.2 and Y is different from H,R.sub.b represents a C.sub.1 -C.sub.3 alkyl group, andR.sub.c.sup.1 and R.sub.c.sup.2, which are identical or different, each represent the hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; and(ii) their addition salts.The said derivatives are useful as pharmaceuticals.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: September 27, 1988
    Assignee: Societe anonyme dite: Laboratoire L. Lafon
    Inventor: Louis Lafon