Abstract: The present invention relates to phenylalkylamino-ketone derivatives, namely the phenyl-(3-hexamethyleneiminopropyl)-ketone and its addition salts, by way of new industrial products.These new products are useful in therapy as vasodilating agents.

Abstract: This invention is drawn to compounds of the formula: ##STR1## in which R is --CH.sub.2 OH, --COOH and --COOR.sub.1, R.sub.1 being a C.sub.1 to C.sub.4 alkyl group, and their pharmaceutically acceptable salts. The compounds of the invention are useful as anti-depressants and as anti-arrhythmics.

Abstract: The present invention relates to new 2-tolylmorpholine derivatives, namely, more precisely,(a) 2-p-tolyl-4-isopropylmorpholine and its addition salts,(b) 2-m-tolyl-4-methylmorpholine and its addition salts,(c) 2-p-tolyl-4-methylmorpholine and its addition salts,(d) 2-o-tolyl-4-tert.-butylmorpholine and its addition salts,(e) 2-p-tolyl-4-tert.-butylmorpholine and its addition salts, and(f) 2-(m-trifluoromethylphenyl)-2-hydroxy-4-ethylmorpholine and its addition salts.These new derivatives are useful in therapy, especially as agents active on the CNS.

Abstract: The present invention relates, by way of a new industrial product, to an acetohydroxamic acid derivative, namely 2-(5-chloro-4-nitro-2-methoxybenzamido)acetohydroxamic acid.This product is useful in therapy, in particular as a sedative.It can be prepared by reacting NH.sub.2 OH with a C.sub.1 -C.sub.3 lower alkyl 5-chloro-4-nitro-2-methoxybenzamidoacetate.

Abstract: The present invention relates to new derivatives of (2,4,6-trimethoxyphenyl)-(3-piperidinopropyl)-ketone which are selected from the group consisting of:(i) (2,4,6-trimethoxyphenyl)-[3-(alkylpiperidino)-propyl)]-ketones of general formula: ##STR1## wherein R.sub.1 is CH.sub.3 or C.sub.2 H.sub.5 in 2- or 3-position of the piperidine ring, andR.sub.2 is H, CH.sub.3 or C.sub.2 H.sub.5 ; and(ii) their addition salts. These new derivatives are useful in therapeutics.

Abstract: The present invention relates to new derivatives selected from the group consisting of:(i) 1-[N-(.alpha.-alkylamino-.alpha.-methylacetyl)aminophenyl]-2-alkylaminopro panones of the general formula: ##STR1## in which R represents a C.sub.1 -C.sub.4 alkyl group and R' represents H or a C.sub.1 -C.sub.4 alkyl group; and(ii) addition salts thereof.These new derivatives are useful as CNS-active substances, in particular as stimulants and antidepressants.The invention also relates to the method for their preparation.

Abstract: The present invention relates to 1-alkyl-3-hydroxy-3-phenylpiperidine derivatives of the formula ##STR1## wherein R is a C.sub.2 -C.sub.4 alkyl group, and their addition salts. These derivatives are useful as pharmaceuticals, especially as CNS-antidepressants.

Abstract: The present invention relates, by way of new industrial products, to the N-alkyl-3-phenyl-1,2,5,6- and 1,4,5,6-tetrahydropyridines of the formulae ##STR1## wherein R is a C.sub.2 -C.sub.4 alkyl group, and their addition salts. These new products are useful as pharmaceuticals, especially as sedative agents.

Abstract: This invention is concerned with a method for preparing a novel porous galenic form by lyophilization of an oil-in-water emulsion containing at least one pharmaceutically active ingredient, which comprises the following steps:(a) preparation of the lipid phase by stirring at a temperature lower than or equal to 80.degree. C. so as to mix all the lipid-phase components, the lipid phase thus prepared being in the liquid state;(b) preparation of the aqueous phase, which comprises at least one substance selected from the group consisting of organic fillers and thickening agents, by stirring at a temperature lower than or equal to 80.degree. C. so as to mix the water and the other components of the aqueous phase;(c) preparation of an emulsion under stirring at a temperature within the range of 10.degree. C. to 80.degree. C.

Abstract: This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of(i) the N-(methoxyphenacyl)-alkylamines of the general formula ##STR1## wherein A is OCH.sub.3, and R is C.sub.3 -C.sub.8 -alkyl or C.sub.3 -C.sub.8 -hydroxyalkyl; and,(ii) addition salts thereof.These new derivatives are useful as pharmaceuticals, in particular as peripheral vasodilating agents.

Abstract: The present invention relates, by way of industrial products, to the 4-alkyl-2-hydroxy-3-methyl-2-phenylmorpholine derivatives of the general formula ##STR1## (in which R is a C.sub.1 -C.sub.4 alkyl group) and their addition salts. These products are useful in therapy, especially as stimulants and antidepressants for the CNS.

Abstract: The present invention relates, by way of new industrial products, to the N-(4-acetylaminophenacyl)-alkylamines of the general formula ##STR1## in which R is isopropyl or tert.-butyl, and their addition salts. These new products are useful in therapy, especially as antidepressants for the CNS.

Abstract: A method for preparing a galenic formulation for pharmaceutical, dietetic, cosmetic or diagnostic use, comprising forming a liquid mixture containing at least one active ingredient and at least one film-forming substance, spraying the mixture at a temperature between 50.degree. and 150.degree. C. to form droplets, drying the droplets in a current of drying gas at a temperature between 100.degree. and 150.degree. C. to obtain coated granules with a diameter comprised between 10 and 20.mu., collecting the coated granules, and subjecting the collected granules to lyophilization.

Abstract: The present invention relates to new industrial products, namely halogeno-benzhydrylsulfinylacetohydroxamic acids of formula: ##STR1## wherein: X.sub.1 is F, Cl, Br or CF.sub.3 ; andX.sub.2, which may be identical to or different from X.sub.1, is H, F, Cl, Br or CF.sub.3.These products are useful in therapeutics, particularly as substances acting on the CNS.

Abstract: The present invention relates as new industrial products to 4-phenoxy-3-butyramidoxime derivatives, characterized in that they are selected from the group consisting of 4-(allylphenoxy)-3-hydroxy-butyramidoximes of formula: ##STR1## and addition salts thereof. These products are useful in therapeutics, particularly as antiarrythmic agents. The compounds of formula I are prepared by reacting the corresponding butyronitrile with hydroxylamine.

Abstract: The present invention relates, as new industrial products, to 3-(aminobenzamido)-propionhydroxamic acids of formula: ##STR1## and their acid addition salts. These products are useful in therapeutics. The compounds of formula I may be prepared by catalytic hydrogenation of the corresponding 3-(nitro-benzamido)-propionhydroxamic acids.

Abstract: The present invention relates to addition salts of substituted aralkylamines of formula:A--CH.sub.2 --NH--R (I)[wherein A is a 3,4-methylenedioxyphenyl group or an .alpha.-hydroxybenzyl, and R is CH(CH.sub.3).sub.2 or C(CH.sub.3).sub.3 ]It relates also to the method for preparing these salts and to their application as pharmaceuticals and in particular as central nervous system antidepressants.

Abstract: A compound having the general formula: ##STR1## wherein Ar is an aryl group (especially an .alpha.-naphthyl, .beta.-naphthyl or phenyl group) which may be substituted by one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylenedioxy halogen, CF.sub.3, NH.sub.2 or NO.sub.2 groups;A is a --CH.sub.2 --, --CHOH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 NH--, --OCH.sub.2 --, --SCH.sub.2 --, --NH--, --NHCOCH.sub.2 --, --CH.sub.2 NHCH.sub.2 -- or --NHCH.sub.2 -- group;Y is O or NH; andB is a single bond and, when A is --CH.sub.2 --S, may be a --CH.sub.2 --, or --CH(CH.sub.3)-- group; and their acid addition salts when Y is NH and their metal salts when Y is O.The compounds and their salts have therapeutic utility in treatment of neuropsychic ailments.

Abstract: The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R.sub.1 R.sub.2 R.sub.3 C-CO-NHOH, in which R.sub.2 and R.sub.3 are each hydrogen or C.sub.1-6 alkyl, and R.sub.1 is C.sub.1-6 alkyl Z.sub.1 Z.sub.2 N (where Z.sub.1 and Z.sub.2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z.sub.3 CH.sub.2 -- (where Z.sub.3 =optionally substituted aryl), Z.sub.4 --A-- (where Z.sub.4 is optionally substituted phenyl or naphthyl, and A is --NH--, --N(C.sub.1-4 alkyl)--, --N(C.sub.5-6 cycloalkyl)--, --NHCO--, --N(C.sub.1-4 alkyl)CO--, --N(C.sub.5-6 cycloalkyl)CO--, --CONH--, --CON(C.sub.1-4 alkyl)--, --CON(C.sub.5-6 cycloalkyl)--, --NHCONH--, --N(C.sub.5 H.sub.6)CONH--, or --N(substituted phenyl)CONH--, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.

Abstract: The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R.sub.1 R.sub.2 R.sub.3 C--CO--NHOH, in which R.sub.2 and R.sub.3 are each hydrogen or C.sub.1-6 alkyl, and R.sub.1 is C.sub.1-6 alkyl Z.sub.1 Z.sub.2 N (where Z.sub.1 and Z.sub.2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z.sub.3 CH.sub.2 --(where Z.sub.3 =optionally substituted aryl), Z.sub.4 --A-- (where Z.sub.4 is optionally substituted phenyl or naphthyl, and A is --NH--, --N(C.sub.1-4 alkyl)--, --N(C.sub.5-6 cycloalkyl)--, --NHCO--, --N(C.sub.1-4 alkyl(CO--, --N(C.sub.5-6 cycloalkyl)CO--, --CONH--, --CON(C.sub.1-4 alkyl)--, --CON(C.sub.5-6 cycloalkyl)-, --NHCONH--, --N(C.sub.5 H.sub.6)CONH--, or --N(substituted phenyl)CONH--, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.