Patents by Inventor Lowell J. Underwood

Lowell J. Underwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular serine protease
    Patent number: 8609819
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: December 17, 2013
    Assignee: Board of Trutees of the University of Arkansas
    Inventors: Timothy J O'Brien, Lowell J Underwood, John Beard, Kazushi Shigemasa
  • Extracellular Serine Protease
    Publication number: 20120264123
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Application
    Filed: June 1, 2012
    Publication date: October 18, 2012
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 8216794
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: July 10, 2012
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 8057999
    Abstract: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: November 15, 2011
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Extracellular serine protease
    Publication number: 20100291124
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Application
    Filed: June 4, 2010
    Publication date: November 18, 2010
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 7759103
    Abstract: The present invention provides a DNA encoding a human Tumor Antigen Derived Gene-14 (TADG-14) protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also, provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 20, 2010
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Lowell J. Underwood, Timothy J. O'Brien
  • Extracellular serine protease
    Patent number: 7732163
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 8, 2010
    Assignee: Board of Trustees of The University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Publication number: 20100120030
    Abstract: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Application
    Filed: March 11, 2009
    Publication date: May 13, 2010
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Publication number: 20100119513
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Application
    Filed: October 6, 2009
    Publication date: May 13, 2010
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Patent number: 7638277
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: December 29, 2009
    Assignee: The University of Arkansas for Medical Sciences
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Uses of antileukoprotease in carcinoma
    Publication number: 20090142328
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Application
    Filed: October 3, 2007
    Publication date: June 4, 2009
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 7537901
    Abstract: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: May 26, 2009
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Lowell J. Underwood, Timothy J. O'Brien
  • Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions
    Patent number: 7309760
    Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain has numerous O-glycosylation sites. Domain 2 is a repeat domain comprising homologous repeat units of 156 amino acids. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units are the sites of OC125 and M11 antibody binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: December 18, 2007
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, John B. Beard, Lowell J. Underwood
  • Extracellular serine protease
    Patent number: 7157084
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: January 2, 2007
    Assignee: The Board of Trustees of The University of Arkansas System
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Extracellular serine protease
    Patent number: 7083790
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: August 1, 2006
    Assignee: The Board of Trustees of the University of Arkansas Systems
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Extracellular serine protease
    Patent number: 7067250
    Abstract: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: June 27, 2006
    Assignee: The University of Arkansas for Medical Sciences
    Inventors: Lowell J. Underwood, Timothy J. O'Brien
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Patent number: 7067630
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: June 27, 2006
    Assignee: The Board of Trustees of The University of Arkansas System
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Extracellular serine protease
    Patent number: 7014993
    Abstract: The present invention provides a DNA encoding a Tumor Antigen Derived Gene TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: March 21, 2006
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Publication number: 20030207316
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Application
    Filed: June 5, 2003
    Publication date: November 6, 2003
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Extracellular serine protease
    Patent number: 6642013
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: November 4, 2003
    Assignee: The University of Arkansas for Medical Sciences
    Inventors: Timothy J. O'Brien, Lowell J. Underwood