Patents by Inventor Lowell J. Underwood

Lowell J. Underwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular serine protease
    Publication number: 20030199010
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Application
    Filed: June 13, 2003
    Publication date: October 23, 2003
    Applicant: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Uses of antileukoprotease in carcinoma
    Publication number: 20030170759
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Application
    Filed: April 8, 2003
    Publication date: September 11, 2003
    Applicant: Board of Trustees of University of Arkansas
    Inventors: Timothy J. O' Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Uses of antileukoprotease in carcinoma
    Patent number: 6602674
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: August 5, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions
    Publication number: 20030143667
    Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding.
    Type: Application
    Filed: September 27, 2001
    Publication date: July 31, 2003
    Inventors: Timothy J. O'Brien, John B. Beard, Lowell J. Underwood
  • Tumor antigen-derived gene 16 (TADG-16): a novel extracellular serine protease and uses thereof
    Publication number: 20030027144
    Abstract: The present invention provides a DNA encoding a TADG-16 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-16 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-16 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-16 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 6, 2003
    Applicant: The University of Arkansas for Medical Sciences
    Inventors: Lowell J. Underwood, Timothy J. O'Brien, Kazushi Shigemasa
  • Extracellular serine protease
    Publication number: 20020037581
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Application
    Filed: February 28, 2001
    Publication date: March 28, 2002
    Applicant: UAB Research Foundation
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Patent number: 6294663
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: September 25, 2001
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma
    Patent number: 6291663
    Abstract: The present invention provides a DNA encoding a TADG-12 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-12 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-12 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-12 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: September 18, 2001
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood