Abstract: Present invention provides a bioactive fraction of Anisomeles indica, TSYI-813, and its preparation which includes extracting Anisomeles indica using an alcohol solvent, fractioning the extract of Anisomeles indica by an organic solvent and water, and purifying via a silica column chromatography with 10:1˜10:5 hexane/ethyl acetate for sequential elution to give the bioactive fraction of Anisomeles indica, TSYI-813. The bioactive fraction of Anisomeles indica, TSYI-813, disclosed in present invention can can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.

Abstract: An anti-collision control method and a rail vehicle control system are provided. The rail vehicle control system includes a control apparatus configured to implement the anti-collision control method to prevent a plurality of vehicles on a plurality of rails from colliding with each other. The anti-collision control method includes receiving a transfer requirement data to decide which one of the vehicles and which one of the rails are respectively an assigned vehicle and an assigned rail; planning a movement path and a movement space according to the transfer requirement data and a vehicle dimension data; determining whether any portion of the movement space is reserved; and in response to the movement space being reserved, the assigned vehicle is controlled to not move, or the movement space is reserved and the assigned vehicle is controlled to move according to the movement path along the assigned rail.

Abstract: A modified modulated wave acquisition method includes: obtaining a modulated wave uaba; calculating a difference between the given value iNq* and the actual value iNq of the q-axis component of a grid side current, inputting the result to a proportional integral (PI) controller, and multiplying an output of the PI controller by cos ?t to obtain a modulated wave offset ?uaba; and calculating a difference between the modulated wave uaba and the modulated wave offset ?uaba to obtain a modified modulation wave uaba?, where ?t is a grid voltage phase in a sinusoidal case. The MPC method for a single-phase cascaded H-bridge rectifier includes: obtaining the modified modulated wave uaba?, where the component iNq* is 0; and replacing the modulated wave uaba with the modified modulated wave uaba? to perform MPC for the single-phase cascaded H-bridge rectifier.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract: A virtual co-phase power supply system topology suitable for an electrical sectioning device at a sectioning and paralleling post (SP) includes a step-down transformer TR1. A primary winding of the step-down transformer TR1 is electrically connected to a traction feeding section ?2 in a train from a traction feeding section ?1 to the traction feeding section ?2. Each secondary winding is electrically connected to one rectifier separately. DC buses output from the rectifiers are connected in parallel. The other end of the DC bus is electrically connected to a plurality of parallel inverter units. An LC filter is provided on a DC bus between a rectifier unit and the inverter unit, and the LC filter is connected in parallel to an energy storage unit. After filtering through the LC filter, an output end of the inverter unit is electrically connected to a primary winding of a step-up transformer TR2.

Abstract: A modified modulated wave acquisition method includes: obtaining a modulated wave uaba; calculating a difference between the given value iNq* and the actual value iNq of the q-axis component of a grid side current, inputting the result to a proportional integral (PI) controller, and multiplying an output of the PI controller by cos ?t to obtain a modulated wave offset ?uaba; and calculating a difference between the modulated wave uaba and the modulated wave offset ?uaba to obtain a modified modulation wave uaba?, where ?t is a grid voltage phase in a sinusoidal case. The MPC method for a single-phase cascaded H-bridge rectifier includes: obtaining the modified modulated wave uaba?, where the component iNq* is 0; and replacing the modulated wave uaba with the modified modulated wave uaba? to perform MPC for the single-phase cascaded H-bridge rectifier.

Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

Abstract: Present invention provides an Anisomeles indica extract comprising ovatodiolide, apigenin-7-glucuronide, acteoside or scutellarin which can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.

Abstract: Present invention provides a bioactive fraction of Anisomeles indica, TSYI-813, and its preparation which includes extracting Anisomeles indica using an alcohol solvent, fractioning the extract of Anisomeles indica by an organic solvent and water, and purifying via a silica column chromatography with 10:1˜10:5 hexane/ethyl acetate for sequential elution to give the bioactive fraction of Anisomeles indica, TSYI-813. The bioactive fraction of Anisomeles indica, TSYI-813, disclosed in present invention can can be used as an effective ingredient for treating or improving gastric ulcers, including reducing the area of ulcer and inflammation in the stomach tissue.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.

Abstract: In an approach, data of a plurality of points is sampled in a target area, wherein the data of each point of the plurality of points comprises position information and a height value. A first area of a target area is determined, wherein the height value of each point of the plurality of points in the first area complies with a first range. A second area of the target area is determined, wherein the height value of each point of the plurality of points in the second area complies with a second range. A third area of the target area is determined, wherein the height value of each point of the plurality of points in the third area complies with a third range. A first pattern is generated, wherein the first pattern is a combination of the first area and the third area.

Abstract: Disclosed in the present invention are a salt type and crystal type of 4H-pyrazolo[1, 5-alpha]benzimidazole compound and the preparation method and intermediate thereof. The 4H-pyrazolo[1,5-alpha]benzimidazole compound has the structure of Compound 2.

Abstract: A rail vehicle system, a rail vehicle, and a visual sensing device are provided. The rail vehicle system includes a system control device, a rail, and a rail vehicle. The rail vehicle includes a processing device and the visual sensing device. In a process where the rail vehicle travels along the rail, the visual sensing device captures images in front of the rail vehicle, and the visual sensing device emits a laser beam toward a front side of the rail vehicle. The visual sensing device receives the reflected laser beam to generate a laser sensing data. The processing device determines whether or not to change at least one of a travel direction and a travel speed of the rail vehicle according to the images captured by the visual sensing device and the laser sensing data.

Abstract: A hydrogen circulation system for fuel cell includes a hydrogen supply pipeline, a return pipeline, a buffer tank, an ejector, a differential pressure valve, a solenoid valve, and a controller. The return pipeline connects a hydrogen outlet of a fuel cell stack and the hydrogen supply pipeline. The buffer tank is installed at the return pipeline. The ejector is installed at the hydrogen supply pipeline for connecting the buffer tank. The differential pressure valve is between a hydrogen source and the ejector for adjusting a pressure in the hydrogen supply pipeline based on a pressure difference between an anode inlet and a cathode inlet of the fuel cell stack. The solenoid valve is installed at the return pipeline between the buffer tank and the hydrogen outlet. According to an output voltage or a load of the fuel cell stack, a switch of the solenoid valve is controlled by the controller.

Abstract: The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

Abstract: Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

Abstract: A modular apparatus of fuel cell system includes a start burner, a reformer, an after-burner, and a heat exchanger. The start burner, the reformer, the after-burner, and the heat exchanger are disposed in a chamber. The start burner is surrounded by the reformer, and the after-burner is disposed on the start burner and surrounds the reformer. The heat exchanger surrounds the after-burner and the reformer.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.