Patents by Inventor Lubert Stryer

Lubert Stryer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7374878
    Abstract: The use of sensory G protein-coupled receptors that recognize chemical sensants, parti-cularly those involving olfactory and taste receptors; polypeptide fragments and mutants thereof; classes of such receptors; polynucleotides encoding such receptors, fragments and mutants thereof, and representatives of receptor classes; genetic vectors including such polynucleotides; and cells and non-human organisms engineered to express such receptor complexes, fragments and mutants of an olfactory or taste receptor, and representatives of receptor classes to simulate sensory perception of odorants and tastants is described. The use of such products as a biosensor or a component thereof to detect, identify, measure, or otherwise process the event of binding between the receptor and its cognate ligand (i.e., chemical sensant) is also described. The invention has application, for example, in the design and formulation of odorant and tastant compositions.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 20, 2008
    Assignee: Senomyx, Inc.
    Inventors: Lubert Stryer, Sergey Zozulya
  • Patent number: 7252948
    Abstract: This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tuberculosis rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: August 7, 2007
    Assignee: Affymetrix, Inc.
    Inventors: Thomas R. Gingeras, David Mack, Mark S. Chee, Anthony J. Berno, Lubert Stryer, Ghassan Ghandour, Ching Wang
  • Publication number: 20060292614
    Abstract: The invention provides methods of monitoring expression of a plurality of genes in a cell or small population of cells. Preferred methods entail contacting an array of probes with a population of nucleic acids derived from a population of fewer than 1000 cells then determining the relative hybridization of the probes to the population of nucleic acid as a measure of the relative representation of genes from the cells. The invention further provides methods of classifying cells. These preferred methods entail determining an expression profile of each of a plurality of cells then classifying the cells in clusters determined by similarity of expression profile. The invention further provides methods of monitoring differentiation of a cell lineage. These preferred methods entail determining an expression profile of each of a plurality of cells at different differentiation stages within the lineage. These cells can then be classified into clusters determined by similarity of expression profile.
    Type: Application
    Filed: August 29, 2006
    Publication date: December 28, 2006
    Applicant: Affymetrix, Inc.
    Inventors: Yanxiang Cao, Lubert Stryer, David Lockhart, Catherine Dulac, Ian Tietjen, Jason Rihel
  • Publication number: 20060210452
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: August 25, 2005
    Publication date: September 21, 2006
    Inventors: Stephen Fodor, Lubert Stryer, James Winkler, Christopher Holmes, Dennis Solas
  • Publication number: 20060204970
    Abstract: This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tuberculosis rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.
    Type: Application
    Filed: February 4, 2005
    Publication date: September 14, 2006
    Inventors: Thomas Gingeras, David Mack, Mark Chee, Anthony Berno, Lubert Stryer, Ghassan Ghandour, Ching Wang
  • Publication number: 20060194224
    Abstract: A computer system for sequencing nucleic acids is provided. The computer system may be used for de novo sequencing of a nucleic acid sequence by analyzing the fluorescence intensities of hybridized nucleic acid probes on biological chips. The probes with the highest intensities are utilized to sequence the nucleic acid and related probes are analyzed to increase the accuracy of nucleic acid sequencing. The sequence of the nucleic acid sequence may be determined from hybridization intensities that do not allow identification of perfectly complementary probes.
    Type: Application
    Filed: December 13, 2005
    Publication date: August 31, 2006
    Applicant: Affymetrix, Inc.
    Inventor: Lubert Stryer
  • Publication number: 20060194258
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: April 17, 2006
    Publication date: August 31, 2006
    Applicant: AFFYMETRIX, INC.
    Inventors: Michael Pirrung, Lubert Stryer, Stephen Fodor, J. Read
  • Publication number: 20060177843
    Abstract: This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tuberculosis rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.
    Type: Application
    Filed: October 20, 2005
    Publication date: August 10, 2006
    Applicant: Affymetrix, INC.
    Inventors: Thomas Gingeras, David Mack, Mark Chee, Anthony Berno, Lubert Stryer, Ghassan Ghandour, Ching Wang
  • Patent number: 7087732
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: August 8, 2006
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Publication number: 20060094040
    Abstract: Systems and methods of synthesizing probes on a substrate are provided. One or more shift reticles are utilized to uniformly add monomers to the substrate at specified locations. The shift reticles are shifted relative to the substrate between monomer addition steps. Additionally, characteristics of the desired probes may be specified at synthesis time.
    Type: Application
    Filed: September 21, 2005
    Publication date: May 4, 2006
    Applicant: Affymetrix, INC.
    Inventors: Earl Hubbell, Lubert Stryer, Michael Mittmann
  • Patent number: 6955915
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: October 18, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
  • Publication number: 20050214828
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: January 21, 2005
    Publication date: September 29, 2005
    Applicant: Affymetrix, INC.
    Inventors: Michael Pirrung, J. Read, Stephen Fodor, Lubert Stryer
  • Publication number: 20050208537
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 22, 2005
    Applicant: Affymetrix, INC.
    Inventors: Stephen Fodor, Lubert Stryer, Michael Pirrung, J. Read
  • Patent number: 6924094
    Abstract: This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tubercluosis rpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: August 2, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Thomas R. Gingeras, David Mack, Mark S. Chee, Anthony J. Berno, Lubert Stryer, Ghassan Ghandour, Ching Wang
  • Patent number: 6919211
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 19, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
  • Publication number: 20050153363
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: November 23, 2004
    Publication date: July 14, 2005
    Inventors: Michael Pirrung, Lubert Stryer, Stephen Fodor, J. Read
  • Publication number: 20050153362
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: November 23, 2004
    Publication date: July 14, 2005
    Inventors: Michael Pirrung, Lubert Stryer, Stephen Fodor, J. Read
  • Publication number: 20050148027
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: November 23, 2004
    Publication date: July 7, 2005
    Applicant: Affymetrix Inc.
    Inventors: Michael Pirrung, J. Read, Stephen Fodor, Lubert Stryer
  • Publication number: 20050118706
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: November 23, 2004
    Publication date: June 2, 2005
    Applicant: AFFYMETRIX, INC.
    Inventors: Michael Pirrung, Lubert Stryer, Stephen Fodor, J. Read
  • Publication number: 20050095638
    Abstract: A method and library for determining the sequence of monomers in a polymer which is complementary to a receptor. The method provides for formation of pooled (6) and separate (10, 12) products. Separate products are subjected only to subsequent pooled coupling steps. Each pooled product is subsequently divided for formation of pooled and separate products. The resulting polymer library includes groups of polymer products. A first group of products (42) is used to identify the monomer at a first location in a polymer that is complementary to a receptor. A second group of products (44) is used to identify the monomer at a second location in a polymer that is complementary to a receptor.
    Type: Application
    Filed: November 19, 2004
    Publication date: May 5, 2005
    Inventors: Stephen Fodor, Lubert Stryer