Patents by Inventor Lubert Stryer

Lubert Stryer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus comprising polymers
    Publication number: 20050095652
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: November 23, 2004
    Publication date: May 5, 2005
    Applicant: Affymetrix, Inc.
    Inventors: Stephen Fodor, Lubert Stryer, Michael Pirrung, J. Read, Paul Hoeprich
  • Very large scale immobilized polymer synthesis
    Publication number: 20050079529
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: August 27, 2004
    Publication date: April 14, 2005
    Applicant: Affymetrix, INC.
    Inventors: Stephen Fodor, Lubert Stryer, Michael Pirrung, J. Reed, Paul Hoeprich
  • Factorial chemical libraries
    Patent number: 6864048
    Abstract: A library for determining the sequence of monomers in a polymer which is complementary to a receptor includes groups of pooled polymer products; wherein each pool is ordered such that a monomer sequence which binds to a receptor can be identified from the pool order in the library.
    Type: Grant
    Filed: April 28, 1993
    Date of Patent: March 8, 2005
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer
  • Methods for polymer synthesis
    Patent number: 6747143
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: June 8, 2004
    Assignee: Affymetrix, Inc.
    Inventors: Lubert Stryer, Stephen P. A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Support bound probes and methods of analysis using the same
    Publication number: 20040038268
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Application
    Filed: June 4, 2003
    Publication date: February 26, 2004
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read
  • Very large scale immobilized polymer synthesis
    Publication number: 20030235853
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 2, 2003
    Publication date: December 25, 2003
    Applicant: Affymetrix, INC.
    Inventors: Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read, Michael C. Pirrung
  • Printing oligonucleotide arrays
    Patent number: 6667394
    Abstract: A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: December 23, 2003
    Assignee: Affymetrix, Inc.
    Inventors: R. Fabian Pease, Glenn McGall, Martin J. Goldberg, Richard P. Rava, Stephen P. A. Fodor, Virginia Goss, Lubert Stryer, James L. Winkler
  • Nucleic acid reading and analysis system
    Patent number: 6646243
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: November 11, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
  • Methods of synthesizing a plurality of different polymers on a surface of a substrate
    Patent number: 6630308
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: October 7, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor
  • Printing molecular library arrays
    Publication number: 20030175409
    Abstract: A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.
    Type: Application
    Filed: March 13, 2003
    Publication date: September 18, 2003
    Applicant: Affymetrix, Inc.
    Inventors: R. Fabian Pease, Glenn McGall, Martin. J. Goldberg, Richard P. Rava, Stephen P.A. Fodor, Virginia Goss, Lubert Stryer, James L. Winkler
  • Support bound probes and methods of analysis using the same
    Patent number: 6610482
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: August 26, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Michael C. Pirrung, Lubert Stryer, J. Leighton Read
  • Methods of making nucleic acid or oligonucleotide arrays
    Patent number: 6600031
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: July 29, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Nucleotides and analogs having photoremovable protecting groups
    Publication number: 20030119008
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: December 28, 2001
    Publication date: June 26, 2003
    Applicant: Affymetrix, Inc.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Very large scale immobilized polymer synthesis
    Publication number: 20030108899
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: July 8, 2002
    Publication date: June 12, 2003
    Applicant: Affymetrix, INC.
    Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read
  • Very large scale immobilized polymer synthesis
    Patent number: 6566495
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 20, 2003
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
  • Very large scale immobilized polymers synthesis
    Publication number: 20030082831
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Application
    Filed: September 30, 2002
    Publication date: May 1, 2003
    Applicant: AFFYMAX TECHNOLOGIES, N.V., a Netherlands Antilles corporation
    Inventors: Stephen P.A. Fodor, Lubert Stryer, James L. Winkler, Christopher P. Holmes, Dennis W. Solas
  • Apparatus for polymer synthesis
    Publication number: 20030064391
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 20, 2002
    Publication date: April 3, 2003
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
  • Nucleic acid reading and analysis system
    Publication number: 20030013100
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: March 15, 2002
    Publication date: January 16, 2003
    Applicant: Affymetrix, INC.
    Inventors: Stephen P.A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
  • Very large scale immobilized polymer synthesis
    Patent number: 6506558
    Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: January 14, 2003
    Assignee: Affymetrix Inc.
    Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
  • Apparatus for polymer synthesis
    Publication number: 20020192693
    Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
    Type: Application
    Filed: May 15, 2002
    Publication date: December 19, 2002
    Applicant: Affymetrix, Inc.
    Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P.A. Fodor, Lubert Stryer