Patents by Inventor Luc Berghman

Luc Berghman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of enhancing immune responses to or limiting infection
    Patent number: 11904005
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: February 20, 2024
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION
    Publication number: 20220288175
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Application
    Filed: May 25, 2022
    Publication date: September 15, 2022
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
    Patent number: 11382962
    Abstract: Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: July 12, 2022
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System
    Inventors: Olivia B. Faulkner, Lisa Bielke, Leona Nicole Calhoun, Luc Berghman, Billy Hargis
  • Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
    Patent number: 11364290
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: June 21, 2022
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University System
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • Mosaic chimeric viral vaccine particle
    Patent number: 11352416
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: June 7, 2022
    Assignee: The TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • Compositions and methods of enhancing immune responses to enteric pathogens
    Patent number: 11013792
    Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: May 25, 2021
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
  • Mosaic Chimeric Viral Vaccine Particle
    Publication number: 20210101962
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Application
    Filed: November 17, 2020
    Publication date: April 8, 2021
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION
    Publication number: 20210008184
    Abstract: Vaccine, vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Application
    Filed: September 17, 2020
    Publication date: January 14, 2021
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • Compositions and methods of enhancing immune responses to
    Patent number: 10842858
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: November 24, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM, THE UNIVERSITY OF GUELPH
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
  • Mosaic chimeric viral vaccine particle
    Patent number: 10836809
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: November 17, 2020
    Assignee: The Texas A&M University System
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • Compositions and methods of enhancing immune responses to or limiting infection
    Patent number: 10792351
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: October 6, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • YEAST VACCINE VECTOR INCLUDING IMMUNOSTIMULATORY AND ANTIGENIC POLYPEPTIDES AND METHODS OF USING THE SAME
    Publication number: 20200297825
    Abstract: Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, The Texas A&M University System
    Inventors: Olivia B. Faulkner, Lisa Bielke, Leona Nicole Calhoun, Luc Berghman, Billy Hargis
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS
    Publication number: 20200297832
    Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 24, 2020
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
  • Compositions and methods of enhancing immune responses to enteric pathogens
    Patent number: 10716840
    Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: July 21, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
  • Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
    Patent number: 10682398
    Abstract: Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: June 16, 2020
    Assignees: THE TEXAS A&M UNIVERSITY SYSTEM, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Olivia B. Faulkner, Lisa Bielke, Leona Nicole Calhoun, Luc Berghman, Billy Hargis
  • MOSAIC CHIMERIC VIRAL VACCINE PARTICLE
    Publication number: 20200079838
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Application
    Filed: July 19, 2019
    Publication date: March 12, 2020
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS
    Publication number: 20190351042
    Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 21, 2019
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION
    Publication number: 20190298815
    Abstract: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
    Type: Application
    Filed: June 12, 2019
    Publication date: October 3, 2019
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: John R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
  • Mosaic chimeric viral vaccine particle
    Patent number: 10407491
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 10, 2019
    Assignee: The Texas A&M University System
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • Compositions and methods of enhancing immune responses to enteric pathogens
    Patent number: 10376571
    Abstract: Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 13, 2019
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Lisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem