Patents by Inventor Luc Berghman

Luc Berghman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20140093534
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 3, 2014
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • BI-Specific Diabodies For Masking And Targeting Vaccines
    Publication number: 20140079704
    Abstract: The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.
    Type: Application
    Filed: September 11, 2013
    Publication date: March 20, 2014
    Applicant: The Texas A&M University System
    Inventors: Waithaka Mwangi, Surya Waghela, Luc Berghman
  • Compositions and methods of enhancing immune responses
    Patent number: 8604178
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: December 10, 2013
    Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University of System
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20120282291
    Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
    Type: Application
    Filed: January 21, 2011
    Publication date: November 8, 2012
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS, THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Luc Berghman, Walter Bottje, Billy Hargis, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM
    Publication number: 20110159026
    Abstract: Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
    Type: Application
    Filed: October 30, 2008
    Publication date: June 30, 2011
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA
    Publication number: 20110111015
    Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 12, 2011
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
  • COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES
    Publication number: 20110027309
    Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
    Type: Application
    Filed: September 18, 2007
    Publication date: February 3, 2011
    Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
  • METHODS AND SYSTEMS FOR DETECTION OF CONTAMINANTS
    Publication number: 20100120016
    Abstract: An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer supported by the housing and operable to measure impedance of the starting material to detect the presence of a contaminant.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 13, 2010
    Inventors: Yanbin Li, Billy Hargis, Steve Tung, Luc Berghman, Walter Bottje, Ronghui Wang, Zunzhong Ye, Madhukar Varshney, Balaji Srinivasan