Abstract: A random number generator comprising a light source (7) configured to emit photons (10) throughout a light emission time interval, a photosensor (12) configured to absorb photons emitted from the light source throughout a light absorption time interval concurrent with the light emission time interval thereby to generate a continuous electrical output signal (13) extending throughout the absorption time interval, and a processor (14) configured to determine temporal variations in the continuous electrical output signal and to generate therefrom one or more quantum random numbers (15).

Abstract: A cutting tool includes a supporting body and a cBN or PCD cutting edge tip attached to the supporting body via a 5-150 ?m braze joint. The supporting body is cemented carbide having 3-25 wt % of a metallic binder, optionally up to 25 wt % of carbides or carbonitrides of one or more elements of group 4, 5, or 6, and the rest WC. The metallic binder includes at least 40 wt % Ni, and the braze joint has, in the order from the supporting body, a first layer of TiC situated next thereto, with an average thickness of 10-400 nm, a second layer, with an average thickness of 0.5-8 ?m, having in average at least 5 wt % metallic Ni, in average 25-60 wt % metallic Cu and in average 15-45 wt % metallic Ti, and a third layer, with an average thickness of 4-145 ?m, having metallic Ag and metallic Cu.

Abstract: The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching technology.

Abstract: A sintered cemented carbide insert for mining or cutting applications includes a mean WC grain size of between 0.8-18 ?m, a binder phase in a weight between 4-18 wt %, a gamma phase with the cubic gamma phase precursors in a weight of between 0.8-10 wt %, and any unavoidable impurities and a balance of WC. A difference between the hardness at any point 0.3 mm from the surface of the insert and the hardness of the bulk is at least 25 HV3, wherein hardness is measured according to ISO EN6507. A method of producing the cemented carbide is also provided.

Abstract: Disclosed are systems and methods that provide a novel framework that automatically and dynamically adjusts and controls the real-world conditions of an environment within a location. Such adjustment can be based on characteristics of items and/or persons within a location, such that the integrity of the items are prevented from being compromised. The framework can function by determining and enforcing safe thresholds for environmental conditions (e.g., temperature and humidity, for example) using artificial intelligence and/or machine learning (AI/ML) techniques. Climate and environmental condition information within the location, as well as attributes/characteristics of the location and/or items therein can be accounted for, and leveraged in determining environmentally safe thresholds that can be utilized for monitoring the location. When real-world conditions in the environment approach and/or exceed the safe thresholds, a climate system (e.g.

Abstract: An anchoring system for floating platform which eliminates the pitch and roll movements of the floating platform using anchoring lines (200) attached to the seabed (5), which are supported by several pulleys or rotary fixing means (2, 3) of the floating platform (100) and are all joined in a common counterweight (1) hanging from the floating platform (100). Each anchoring line (200) comprises a direct subline (200d) and a cross subline (200c), which maintain the counterweight (1) always located in correspondence with the central axis (300) of the floating platform (100). It also describes a novel method for installing the floating platform at its destination without the aid of special ships.

Abstract: A modular tool anchor includes an anchor body positionable about a tubular. The anchor includes an anchor wedge for gripping against the tubular. A wedge drive screw engages a piston that biases the wedge into contact with the tubular as the wedge drive screw is tightened. The anchor also includes a compression seal positioned within the anchor body. A sealing flange abuts the compression seal. As seal compression screws are tightened, the sealing flange engages the compression seal and forces it against the tubular.

Abstract: Dual composition block copolymers made from conjugated diene and monovinyl aromatic monomers in batch organolithium initiated polymerization show advantageous performance in the production of crosslinked microcellular rubber compounds and pressure sensitive hot melt adhesives. The dual composition block copolymers are partially coupled with a coupling agent linking inner monovinyl aromatic blocks. Their un-coupled low molecular weight fraction has greater monovinyl aromatic repeating unit content than their coupled high molecular weight fraction. Crosslinked microcellular rubber articles made from the dual composition block copolymers exhibit lower density, smaller and more homogeneous cell size, higher softness and higher resiliency than prior art block copolymers. Rubber compounding of formulations comprising the dual composition block copolymers proceed at slightly lower torque and slightly lower temperature than with prior art block copolymers.

Abstract: Certain examples described herein control an amount of a functional agent that is deposited in a three-dimensional printing system. In certain examples, an amount of a functional agent is controlled based on a distance function, wherein the distance function is associated with a distance between a particular portion of an object to be fabricated and a surface of the object. The functional agent may be a binder, a fusing agent or a detailing agent, amongst others.

Abstract: A radiation shield for blocking radiation at a gas turbine piping connection joint is provided. The radiation shield is configured to surround the gas turbine piping connection joint. The radiation shield includes at least two shield portions in contact with one another at a pair of flanged ends. The at least two shield portions collectively define an opening. Each shield portion of the at least two shield portions includes an inner shell, an outer shell, and insulation disposed between the inner shell and the outer shell. One of the inner shell or the outer shell includes a pipe connection bracket that extends into the opening.

Abstract: A radiation shield assembly for blocking radiation at a gas turbine piping connection joint is provided. The radiation shield assembly includes a radiation shield configured to surround the gas turbine piping connection joint. The radiation shield includes at least two shield portions coupled to one another at a pair of flanged joints. Each shield portion of the at least two shield portions include an inner shell, an outer shell, and insulation disposed between the inner shell and the outer shell.

Abstract: This disclosure includes techniques for controlling smart home devices upon entering a home with a fingerprint sensor in a doorbell device. After capturing a fingerprint of a digit of a guest and sending the fingerprint to a server device, the server device matches the fingerprint of the digit to an entry in a guest fingerprint database for a first user. The server device sends an operational command to a smart home device separate from the doorbell device and located at a same premises as the doorbell device. In response to receiving the operational command from the server device, the smart home device performs an action corresponding to the operational command.

Abstract: The present invention provides tyrosinase-inhibiting molecules of general formula (I) and a dermopharmaceutical or cosmetic composition that includes at least one of said tyrosinase-inhibiting molecules.

Abstract: The present invention relates to a process for the manufacture of microporous carbon materials to perform selective separations of nitrogen in gas mixtures such as hydrogen sulfide, carbon dioxide, methane and C2, C3 and C4+ hydrocarbons, with high efficiency, shaped of microspheres or cylinders from copolymers of poly (vinylidene chloride-co-methyl acrylate) with density of 1.3 to 1.85 g/cm·sup·3 or poly (vinylidene chloride-co-vinyl chloride) with density of 1.3 to 1.85 g/cm.sup.3, using two stages. The first stage consists of a surface passivation of the material by chemical attack in a highly alkaline alcohol solution, with the aim of effecting a precarbonization on the surface of the copolymer that during the pyrolysis process is not deformed and gradually develops microporosity. The material of the first stage presents, in the layer, percentages between 55% to 85% carbon, between 5% to 20% oxygen, and between 10% to 40% chlorine.

Abstract: A modulo-based ADC implementation is provided and involves converting an input analog signal into phases of other M periodic analog reference signals based on one or more transfer functions, wherein M?2. The phase of each of the M reference signals comprises a folded signal corresponding to the input analog signal that is amplitude-folded to fall within a required amplitude range. This signal-to-phase conversion allows a modulo operation to be implemented over the input analog signal. Further, the M reference signals are used to obtain M discrete-time digital signals which, in turn, are used to obtain a digital representation of the input analog signal.

Abstract: Epidermolysis bullosa (EB) is caused by mutations in the COL7A1 gene encoding type VII collagen. EB comprises a phenotypically diverse group of inherited blistering diseases that affect the skin, and possibly mucous membranes and other organs A number of therapeutic strategies have been explored for managing the treatment of EB, such as (i) surgery, (ii) chemotherapy, (iii) use of collagenase activity inhibitors, (iv) use of antibiotics, (v) use of anti-inflammatory compound, (vi) cell therapies, (viii) protein therapy as well as (ix) gene therapy. Gene therapy of EB aimed to provide therapeutic benefit through manipulation of DNA or RNA. Anti-sense therapy targeting specific exons have been described, such as targeting exons 73 and 80. However, this kind of therapeutic strategy had to be improved as regards its pharmaceutical compliance.

Abstract: Embodiments are directed to low-profile, low-weight cargo loader, including a pair of cargo loaders including a first cargo loader arranged in tandem with a second cargo loader in a first orientation. According to an embodiment, each of the first cargo loader and the second cargo loader includes a chassis, a scissor lift, a platform, a front driving system, and a rear driving system. According to an embodiment, the second cargo loader is configured to be stacked on the first cargo loader in a second orientation.

Abstract: The present invention relates to a process for the manufacture of microporous carbon materials to perform selective separations of nitrogen in gas mixtures such as hydrogen sulfide, carbon dioxide, methane and C2, C3 and C4+ hydrocarbons, with high efficiency, shaped of microspheres or cylinders from copolymers of poly (vinylidene chloride-co-methyl acrylate) with density of 1.3 to 1.85 g/cm3 or poly (vinylidene chloride-co-vinyl chloride) with density of 1.3 to 1.85 g/cm3, using two stages. The first stage consists of a surface passivation of the material by chemical attack in a highly alkaline alcohol solution, with the aim of effecting a precarbonization on the surface of the copolymer that during the pyrolysis process is not deformed and gradually develops microporosity. The material of the first stage presents, in the layer, percentages between 55% to 85% carbon, between 5% to 20% oxygen, and between 10% to 40% chlorine.

Abstract: A method of treating a sintered mining insert including cemented carbide includes the step of subjecting the mining insert to a surface hardening process. The surface hardening process is executed at an elevated temperature of or above 100° C. A mining insert is also provided, wherein the HV1 Vickers hardness measurement increase (HV1%) from the surface region, measured as an average of HV1 measurements taken at 100 ?m, 200 ?m and 300 ?m below the surface, compared to the HV1 Vickers hardness measured in the bulk (HV1bulk), is at least 8.05-0.00350×HV1bulk.

Abstract: A cemented carbide including an eta phase and a Ni—Al binder is provided. The Ni—Al binder includes intermetallic y?-Ni3Al -precipitates embedded in a substitutional solid solution matrix of Al and Ni. A weight ratio Al/Ni of between 0.03 to 0.10, wherein a total amount of Ni and Al is between 70 to 95 wt % of the total binder A method of making a cutting tool is also provided.