Abstract: A microfluidic valve assembly and a microfluidic sensing platform are provided. The valve assembly has particular utility for separating test fluids from being in contact with a soft substrate, for example, a PDMS substrate. The valve member includes a stretchable membrane positioned to seal a fluid channel. The microfluidic sensing platform is particularly suited for detecting and/or quantifying the presence of one or more target agents in a fluid sample. This system includes a microfluidic chip configured to receive a capture agent and detection agent; a controller configured to control flow of a capture agent and a detection agent; and a sensor configured to detect results of the interaction between the target agents and the mixture of the capture agent and the detection agent.

Abstract: In an example, a data unit includes a data unit mounting having a circuitry region, a registration portion, and a retaining feature. Circuitry comprising a data source to provide at least one additive manufacturing parameter is arranged on the circuitry region of the mounting. The data unit mounting is to be removably mounted on a receiving portion of an additive manufacturing build material component, such that the registration portion is to be received in a corresponding guide portion of the receiving portion of the additive manufacturing build material component, and the retaining feature is prevent removal of the data unit from the receiving portion unless deformed. Deformation of the retaining feature to effect removal of the data unit from the receiving portion may be a permanent deformation.

Abstract: Certain examples described herein control an amount of a functional agent that is deposited in a three-dimensional printing system. In certain examples, an amount of a functional agent is controlled based on a distance function, wherein the distance function is associated with a distance between a particular portion of an object to be fabricated and a surface of the object. The functional agent may be a binder, a fusing agent or a detailing agent, amongst others.

Abstract: A cemented carbide cutting tool having WC and a low amount of binder phase can be used when machining Ti, Ti-alloys and Ni-based alloys under cryogenic conditions, leading to a significantly prolonged tool life.

Abstract: A lubricating composition comprising a base oil and one or more additives, wherein the composition has: a sulphated ash content (according to ASTM D 874) of at least 0.4 wt % and at most 1.0 wt. %, by weight of the lubricating composition; a total base number (TBN) value (according to ASTM D 2896) of at least 4.0 mg KOH/g and at most 12 mg KOH/g; a total aromatics content contributed by the base oil in the range from 1 wt % to 30 wt %, by weight of the lubricating composition; and a sulphur content contributed by the base oil of 0.4 wt % or less, by weight of the lubricating composition; and wherein the base oil comprises a blend of (i) a first base oil which is a mineral base oil selected from an API Group I mineral base oil and an API Group II mineral base oil, and mixtures thereof, and (ii) a second base oil selected from an API Group II base oil and an API Group III base oil, preferably wherein the first base oil belongs to a different API group to that of the second base oil.

Abstract: The invention relates to nucleic acids and methods for restoring acid alpha-glucosidase (GAA) activity in patients with Pompe disease using splice-switching technology.

Abstract: An example device includes a camera to aim towards a build platform to receive material to be fused to form an article. The camera is to capture thermal images including a correction image captured during formation of the article at the build platform. The correction image is to be referenced to adjust a parameter of the formation of the article at the build platform. The example device further includes a controller connected to the camera. The controller is to control the camera to capture a calibration image with a heater associated with the build platform turned on. The controller is further to use the calibration image to compute a calibration to apply to the correction image.

Abstract: A cutter for a cutting unit used in cutting apparatus suitable for creating tunnels or subterranean roadways. The cutter includes a disc body having an underside, an upper side arranged substantially opposite to the underside, and a radially peripheral part. A plurality of buttons for abrading rock are mounted in the radially peripheral part of the disc body and protrude outwardly therefrom to engage rock during an undercutting operation, wherein at least some of the buttons have a cutting part having a dome-shaped cutting surface.

Abstract: Examples of additive manufacturing are described. In one example, a method comprises generating print data to cause application of fusing agent to a first region of a layer of build material of an object undergoing additive manufacturing, the first region corresponding to an inner region of an object undergoing additive manufacturing. The print data causes application of fusing agent and detailing agent to a second region of the layer, the second layer corresponding to a middle region of the object. The print data causes application of detailing agent to a third region of the layer, the third region corresponding to an outer layer of the object. Fusing energy is applied to the layer.

Abstract: A three-dimensional object is generated using a build material and a printing agent. A visible property of one of the build material and the printing agent is identified. The other of the build material and the printing agent is selected based at least on the other of the build material and the printing agent having a given visible property. A three-dimensional object is generated using the one of build material and the printing agent having the identified visible property and the other of the build material and the printing agent having the given visible property. The selecting is based at least on the identified visible property and the given visible property having a desired visible property relationship. An apparatus for building a three-dimensional object is also disclosed.

Abstract: A positioning jig for locating drill holes or other targets in a workpiece on which the positioning jig is positioned. The positioning jig includes a pinion body and a pair of arms extending from the pinion body. The pair of arms are engaged with a pinion in the pinion body to provide a rack and pinion mechanism for centering the positioning jig on a workpiece. A jig body including at least one aperture is connected with the pinion body. The jig body may be translated with respect to the pinion body for locating the at least one aperture at a target point on the workpiece for drilling a hole or marking the workpiece.

Abstract: The present invention relates to a process for the manufacture of microporous carbon materials to perform selective separations of nitrogen in gas mixtures such as hydrogen sulfide, carbon dioxide, methane and C2, C3 and C4+ hydrocarbons, with high efficiency, shaped of microspheres or cylinders from copolymers of poly (vinylidene chloride-co-methyl acrylate) with density of 1.3 to 1.85 g/cm3 or poly (vinylidene chloride-co-vinyl chloride) with density of 1.3 to 1.85 g/cm3, using two stages. The first stage consists of a surface passivation of the material by chemical attack in a highly alkaline alcohol solution, with the aim of effecting a precarbonization on the surface of the copolymer that during the pyrolysis process is not deformed and gradually develops microporosity. The material of the first stage presents, in the layer, percentages between 55% to 85% carbon, between 5% to 20% oxygen, and between 10% to 40% chlorine.

Abstract: An additive manufacturing system is described. The system includes a working area with a moveable platform, a supply mechanism to supply a build material to the working area, a radiation source to apply energy to the working area during construction of an object, so as to fuse at least a portion of the build material, a platform advance sensor to determine a displacement of the platform in at least a direction perpendicular to the plane of the platform, and a radiation source controller to adjust the energy applied by the radiation source based on the displacement measured by the platform advance sensor.

Abstract: In an example, a method includes receiving, at a processor, object model data representing at least a portion of an object to be generated by an additive manufacturing apparatus by fusing build material. Using a processor and from the object model data, a property diffusion model for the object in object generation may be determined. Using a processor and based on the property diffusion model, a manufacturing boundary object shell around the object and encompassing an external volume may be determined. The shell may have a variable thickness determined so as to include build material for which, in generation of the object, the property modelled in the property diffusion model has a value which is predicted to conform to a predetermined parameter.

Abstract: A cutting head for cutting apparatus suitable for creating tunnels or subterranean roadways and the like. The cutting head includes a rotatable cutting head body and a plurality of cutting units mounted thereon. The cutting units include at least first and second different types of cutting units. The first type of cutting unit has a first rotatable cutter having a first disc body and a first arrangement of buttons for abrading rock. The first buttons are mounted in a radially peripheral portion of the disc body and protrude outwardly therefrom. The second type of cutting unit has a second rotatable cutter having a second disc body and a second arrangement of buttons. The second buttons are mounted in a radially peripheral portion of the disc body and protrude outwardly therefrom. The different types of cutting units differ from one another by at least the arrangements of their buttons.

Abstract: In an example an additive manufacturing system for generating a three-dimensional object by processing successive layers of build material comprises a controller to: receive data relating to a three-dimensional object to be generated; calculate, based at least in part on the data relating to the three-dimensional object, an estimated time to process each layer of build material; determine the longest time of said estimated times; and configure the additive manufacturing system to process each layer of build material in a time which is the same, within a predetermined tolerance, for all of the layers, and which is at least as long as the determined longest time.

Abstract: In an example, a data unit includes a mounting to removably mount the data unit on a receiving portion of an additive manufacturing build material container, a data source to provide data comprising a plurality of additive manufacturing parameters and a communications interface to communicate with a reader of an additive manufacturing build material processing apparatus. The communications interface is to transmit data from the data source to the additive manufacturing build material processing apparatus.

Abstract: Examples of additive manufacturing are described. In one example, a method comprises generating print data to cause application of fusing agent to a first region of a layer of build material of an object undergoing additive manufacturing, the first region corresponding to an inner region of an object undergoing additive manufacturing. The print data causes application of fusing agent and detailing agent to a second region of the layer, the second layer corresponding to a middle region of the object. The print data causes application of detailing agent to a third region of the layer, the third region corresponding to an outer layer of the object. Fusing energy is applied to the layer.

Abstract: Methods, apparatus, systems, and computer-readable media are provided for generating and applying outgoing communication templates. In various implementations a corpus of outgoing communications sent by a user may be grouped into a plurality of clusters based on one or more attributes of a context of the user. One or more segments of each outgoing communication of a particular cluster may be classified as fixed in response to a determination that a count of occurrences of the one or more segments across the particular cluster satisfies a criterion. One or more remaining segments of each communication of the particular cluster may or may not be classified as transient. Based on sequences of classified segments associated with each communication of the particular cluster, an outgoing communication template may be generated to automatically populate at least a portion of a draft outgoing communication being prepared by the user.

Abstract: A cemented carbide including an eta phase and a Ni—Al binder is provided. The Ni—Al binder includes intermetallic y?-Ni3Al-precipitates embedded in a substitutional solid solution matrix of Al and Ni. A weight ratio Al/Ni of between 0.03 to 0.10, wherein a total amount of Ni and Al is between 70 to 95 wt % of the total binder A method of making a cutting tool is also provided.