Patents by Inventor Luiz Belardinelli

Luiz Belardinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF MULTIDETECTOR COMPUTED TOMAGRAPHY
    Publication number: 20100086483
    Abstract: This invention relates to methods for multidetector computed tomography myocardial perfusion imaging comprising administering doses of a rate-control agent and one or more adenosine A2A receptor agonists to a mammal.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Inventors: Luiz Belardinelli, Brent Blackburn
  • Myocardial perfusion imaging method
    Patent number: 7683037
    Abstract: The present invention relates to methods for myocardial imaging by administering at least one 2-adenosine N-pyrazole, 2-adenosine C-pyrazole or a combination thereof A2A adenosine receptor agonist to a human undergoing myocardial imaging. The invention also relates to methods of producing coronary vasodilation without significant peripheral vasodilation by administering at least one 2-adenosine N-pyrazole, 2-adenosine C-pyrazole or a combination thereof adenosine A2A adenosine receptor agonist to a human.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: March 23, 2010
    Assignee: Gilead Palo Alto, Inc.
    Inventor: Luiz Belardinelli
  • METHOD OF TREATING ATRIAL FIBRILLATION
    Publication number: 20100056536
    Abstract: The present invention relates to a method for the treatment of atrial fibrillation comprising the coadministration of a synergistic therapeutically effective amount of amiodarone and synergistic therapeutically effective amount ranolazine. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 4, 2010
    Inventors: Charles Antzelevitch, Alexander Burashnikov, John Shryock, Sridharan Rajamani, Luiz Belardinelli
  • Use of A2A adenosine receptor agonists
    Patent number: 7655636
    Abstract: The present invention relates to methods for producing coronary vasodilation with little peripheral vasodilation by administering doses of a pharmaceutical composition including regadenoson, named (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide, — an adenosine A2A receptor agonist — to a human in an amount sufficient to increase the average coronary peak flow velocity by at least about 16.5 cm/sec.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: February 2, 2010
    Assignee: Gilead Palo Alto, Inc.
    Inventors: Toufigh Gordi, Ann Walls Olmsted, Hsiao Dee Lieu, Luiz Belardinelli
  • N-pyrazole Areceptor agonists
    Patent number: 7655637
    Abstract: 2-adenosine N-pyrazole compounds having the following formula: wherein R1?CH2OH; R2 is hydrogen; R3 is selected from the group consisting of CO2R20; —CONR7R8 ,and aryl wherein the aryl substituent is optionally substituted with one substituent selected from the group consisting of halo, C 1-3alkyl and OR20;R4 is hydrogen; R7 is selected from hydrogen, and C1-3alkyl; R8 is hydrogen; and R20 is selected from hydrogen and methyl as well as methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart are disclosed.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: February 2, 2010
    Assignee: Gilead Palo Alto, Inc.
    Inventors: Jeff A. Zablocki, Elfatih O. Elzein, Venkata Palle, Luiz Belardinelli
  • METHOD OF TREATING ARRHYTHMIAS
    Publication number: 20100004255
    Abstract: Methods are provided for treating arrhythmias including tachycardias, such as idiopathic ventricular tachycardia, ventricular fibrillation, and Torsade de Pointes (TdP) in a manner that minimizes undesirable side effects.
    Type: Application
    Filed: September 9, 2009
    Publication date: January 7, 2010
    Inventors: Luiz Belardinelli, Charles Antzelevitch, Brent Blackburn
  • Method of Identifying Partial Agonists of the A2A Receptor
    Publication number: 20090317331
    Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 24, 2009
    Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
  • USE OF RANOLAZINE FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
    Publication number: 20090312340
    Abstract: Disclosed are methods for treating patients suffering from cardiovascular diseases comprising administering an intravenous (IV) infusion of ranolazine. In one embodiment, the IV infusion of ranolazine is followed by an orally administered sustained release ranolazine dosage formulation to maintain human ranolazine plasma levels at therapeutic levels in patients.
    Type: Application
    Filed: February 12, 2009
    Publication date: December 17, 2009
    Inventors: Whedy Wang, Ewa Prokopczuk, Luiz Belardinelli, Louis Lange, Markus Jerling, Andrew Wolff
  • Myocardial perfusion imaging method
    Patent number: 7582617
    Abstract: The present invention provides a method for using the partial adenosine A2A receptor agonists having the following structure in myocardiological perfusion imaging.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: September 1, 2009
    Assignee: CV Therapeutics, Inc.
    Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
  • ABCA-1 ELEVATING COMPOUNDS AND METHODS
    Publication number: 20090203689
    Abstract: Disclosed are novel compounds of Formula I useful for treating various disease states, in particular, insulin resistance, diabetes, dyslipidemia, coronary artery disease, and inflammation. The compounds of the present invention elevate cellular expression of the ABCA-1 gene as well as increasing the level of ABCA-1 protein, which may result in an increase in HDL levels in the plasma of a mammal, in particular humans.
    Type: Application
    Filed: February 6, 2009
    Publication date: August 13, 2009
    Inventors: Arvinder Dhalla, Jeffrey Chisholm, Luiz Belardinelli
  • METHODS FOR TREATING PAIN
    Publication number: 20090203707
    Abstract: This invention relates to methods for treating a patient suffering from neuropathic or nociceptive pain which may be mechanical, visceral, and/or inflammatory in nature, comprising administering a therapeutically effective amount of Ranolazine to a patient in need thereof.
    Type: Application
    Filed: February 6, 2009
    Publication date: August 13, 2009
    Inventors: Sridharan Rajamani, John Shryock, Ivan Diamond, Luiz Belardinelli
  • METHOD OF TREATING ARRHYTHMIAS
    Publication number: 20090118221
    Abstract: Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an A1 adenosine receptor agonist with a therapeutically effective minimal dose of a beta blocker, calcium channel blocker, or a cardiac glycoside.
    Type: Application
    Filed: January 9, 2009
    Publication date: May 7, 2009
    Inventors: Luiz Belardinelli, Arvinder Dhalla
  • Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
    Publication number: 20090081120
    Abstract: The present application discloses methods and compositions for increasing patient tolerability during myocardial imaging comprising the administration of doses of caffeine and one or more adenosine A2A receptor agonists to a mammal undergoing myocardial imaging.
    Type: Application
    Filed: June 27, 2008
    Publication date: March 26, 2009
    Inventors: Hsiao Lieu, Brent Blackburn, Luiz Belardinelli
  • Method of treating arrhythmias
    Patent number: 7479485
    Abstract: Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an A1 adenosine receptor agonist with a therapeutically effective minimal dose of a beta blocker, calcium channel blocker, or a cardiac glycoside.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: January 20, 2009
    Assignee: CV Therapeutics, Inc.
    Inventors: Luiz Belardinelli, Arvinder Dhalla
  • METHOD FOR ENHANCING INSULIN SECRETION
    Publication number: 20080255031
    Abstract: The invention is directed to methods for enhancing endogenous insulin levels in a patient in need thereof which method comprises administering to the patient an insulin secretion-enhancing amount of racemic ranolazine or the R- or S-enantiomer of ranolazine. It is also directed to methods of treatment comprising racemic ranolazine or the R- or S-enantiomer of ranolazine for enhancing endogenous insulin levels in a patient in need thereof. It is also directed to a composition comprising an insulin secretion-enhancing amount of racemic ranolazine or the R- or S-enantiomer of ranolazine and at least one anti-diabetic agent.
    Type: Application
    Filed: April 11, 2008
    Publication date: October 16, 2008
    Inventors: Arvinder Dhalla, Luiz Belardinelli, John Shryock, Kwan Leung, Dewan Zeng
  • USE OF RANOLAZINE FOR THE TREATMENT OF CORONARY MICROVASCULAR DISEASES
    Publication number: 20080248112
    Abstract: Disclosed are methods for treating patients suffering from coronary microvascular disease comprising administering ranolazine to the patient.
    Type: Application
    Filed: February 13, 2008
    Publication date: October 9, 2008
    Inventors: Brent Blackburn, Luiz Belardinelli, Andrew Wolff
  • Methods and Compositions for Increasing Patent Tolerability During Myocardial Imaging Methods
    Publication number: 20080213165
    Abstract: The present application discloses methods and compositions for increasing patient tolerability during myocardial imaging comprising the administration of doses of caffeine and one or more adenosine A2A receptor agonists to a mammal undergoing myocardial imaging.
    Type: Application
    Filed: August 31, 2007
    Publication date: September 4, 2008
    Inventors: Hsiao Lieu, Brent Blackburn, Luiz Belardinelli
  • USE OF RANOLAZINE FOR THE TREATMENT OF NON-CORONARY MICROVASCULAR DISEASES
    Publication number: 20080193530
    Abstract: Disclosed are methods for treating patients suffering from non-coronary microvascular disease comprising administering ranolazine to the patient. In one embodiment, ranolazine is administered as an oral dose.
    Type: Application
    Filed: February 13, 2008
    Publication date: August 14, 2008
    Inventors: Brent Blackburn, Luiz Belardinelli, Andrew Wolff
  • Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease
    Publication number: 20080170990
    Abstract: The present application discloses methods for myocardial imaging in human patients having a history of pulmonary disease such as asthma, bronchospasm, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary inflammation, or pulmonary hypertension, comprising administrating doses of one or more A2A adenosine receptor agonists to a mammal undergoing myocardial imaging and detecting and/or diagnosing myocardial dysfunction.
    Type: Application
    Filed: September 28, 2007
    Publication date: July 17, 2008
    Applicant: CV THERAPEUTICS, INC.
    Inventors: Hsiao D. Lieu, Brent Blackburn, Luiz Belardinelli
  • REDUCTION OF CARDIOVASCULAR SYMPTOMS
    Publication number: 20080153840
    Abstract: The present application discloses methods for treating patients with a dysfunction of the ion channels of the heart suffering from one or more cardiovascular diseases to reduce the proarrhythmic effect of drugs and/or conditions that reduce or inhibit IKr.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 26, 2008
    Inventors: Luiz Belardinelli, Lin Wu, Sridharan Rajamani, Arvinder Dhalla