Abstract: In one embodiment, a method for authenticating a user with an electronic device is disclosed. The method incudes receiving digital sensor data from a motion sensor over a signal acquisition time period; deleting a beginning portion of the digital sensor data prior to the signal acquisition time period; suppressing signal components in the data associated with voluntary movement of the user; signal processing the suppressed digital sensor data to extract signal features representing neuro muscular tone of the user; tabulating the extracted signal features over periods of time into a feature vector table; executing a predictive model with the feature vector table; generating a numerical degree of matching level based on the feature vector table and the user parameter set; and making a determination to either authorize the user or not based on the numerical degree of matching level. The predictive model is trained by a user parameter set.

Abstract: A system can include an axial field rotary energy device with an axis of rotation and a rotor coaxial with the axis and having a shaft, bearings, rotor disks that are coaxial and permanent magnets on each rotor disk. A printed circuit board (PCB) stator is located between the rotor disks to define an air gap on each side of the PCB stator. An enclosure has two enclosure sections with an inspection port. Bearing caps and bearings are mounted to the rotor. A variable frequency drive (VFD) assembly is coupled to the axial field rotary energy device. The VFD has a flexible conduit that extends between the VFD housing and the axial field rotary energy device. The flexible conduit can adapt to different sizes of axial field rotary energy devices.

Abstract: Combined dissolution rate and permeation rate testing apparatus includes temperature-controllable testing cell units arranged on a housing frame. Each testing cell unit includes a donor chamber receivable of dissolution media, a receptor chamber receivable of bodily fluid, gaskets that retain a membrane between the two chambers, and controllable mixers that mix the fluid in the receptor chamber. A flow control arrangement operatively circulates dissolution media through the donor chamber and enables sampling of the dissolution media. Another flow control arrangement operatively circulates bodily fluid through the receptor chamber. An analysis unit analyzes dissolution media removed from the donor chamber and bodily fluid removed from the receptor chamber to provide data about dissolution of a pharmaceutical product dissolved in the dissolution media and permeation of the pharmaceutical product through the membrane into the bodily fluid.

Abstract: Dissolution tester assembly that tests pharmaceutical tablets includes a frame that operatively supports a vessel having an interior into which a tablet is placed, a camera assembly supported by the frame and including a shaft having a hollow portion and an end that extends into the vessel interior, and an imaging system for imaging the tablet during the dissolution process to enable display of the images on a monitor. The imaging system includes a first camera positioned in the hollow portion of the shaft and oriented to image downward toward a bottom of the vessel, and/or a second camera positioned on the frame at a location directly below the vessel and oriented to image upward toward the bottom of the vessel. An attachment, such as a paddle for stirring or a basket for retaining the tablet, may be positioned at the end of the shaft in the vessel.

Abstract: Combined dissolution rate and permeation rate testing apparatus includes temperature-controllable testing cell units arranged on a housing frame. Each testing cell unit includes a donor chamber receivable of dissolution media, a receptor chamber receivable of bodily fluid, gaskets that retain a membrane between the two chambers, and controllable mixers that mix the fluid in the receptor chamber. A flow control arrangement operatively circulates dissolution media through the donor chamber and enables sampling of the dissolution media. Another flow control arrangement operatively circulates bodily fluid through the receptor chamber. An analysis unit analyzes dissolution media removed from the donor chamber and bodily fluid removed from the receptor chamber to provide data about dissolution of a pharmaceutical product dissolved in the dissolution media and permeation of the pharmaceutical product through the membrane into the bodily fluid.

Abstract: The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:—a. contacting a substrate that includes a plurality of discrete platelet-binding zones having a surface area of 7850 ?m2 orless with a fluid composition comprising platelets; and b. detecting platelets bound to the platelet-binding zones and thereby characterising platelets.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: Dissolution tester assembly that tests pharmaceutical tablets includes a frame that operatively supports a vessel having an interior into which a tablet is placed, a camera assembly supported by the frame and including a shaft having a hollow portion and an end that extends into the vessel interior, and an imaging system for imaging the tablet during the dissolution process to enable display of the images on a monitor. The imaging system includes a first camera positioned in the hollow portion of the shaft and oriented to image downward toward a bottom of the vessel, and/or a second camera positioned on the frame at a location directly below the vessel and oriented to image upward toward the bottom of the vessel. An attachment, such as a paddle for stirring or a basket for retaining the tablet, may be positioned at the end of the shaft in the vessel.

Abstract: A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract: Transdermal diffusion cell testing vessel includes a container defining a chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. The vessel is used for conducting transdermal diffusion cell testing in combination with a solution source fluidly coupled to each vessel, a waste receptacle fluidly coupled to each vessel, a syringe pump fluidly coupled to a respective vessel, and a sample collector fluidly coupled to the syringe pump(s).