Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities.

Abstract: The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising platelets on a substrate for detection and subsequent characterisation, and to devices on which such a method may be practiced. The method comprises the steps of:—a.contacting a substrate that includes a plurality of discrete platelet- binding zones having a surface area of 7850 ?m2 orless with a fluid composition comprising platelets; and b.detecting platelets bound to the platelet-binding zones and thereby characterising platelets.

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract: Transdermal diffusion cell testing vessel includes a container defining a chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. The vessel is used for conducting transdermal diffusion cell testing in combination with a solution source fluidly coupled to each vessel, a waste receptacle fluidly coupled to each vessel, a syringe pump fluidly coupled to a respective vessel, and a sample collector fluidly coupled to the syringe pump(s).

Abstract: Vessel for transdermal diffusion cell testing includes a container defining an interior chamber having an opening against which skin is placed, and a casing arranged partially around and spaced apart from part of the container to define a compartment therebetween. The chamber retains a saline solution and is not in flow communication with the compartment through which water is circulated. The vessel includes separate inlet ports and outlet ports, each including a conduit communicating with the chamber or compartment. The outlet port of the chamber is arranged above the inlet port of the chamber, proximate the opening of the chamber, and is angled downward relative to a horizontal upper surface of the container against which skin being tested is placed. Tilting of the vessel prior to or during introduction of solution prevents air bubbles from remaining between the skin and the solution.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: Pharmaceutical product release rate testing device includes a base, at least one carousel member rotatably mounted on the base, each carousel member including a plurality of test tube pockets each adapted to receive a test tube fillable with test media, and a dipping mechanism for dipping samples to be tested into the test tubes when present in the pockets and filled with test media. A rinsing/filling mechanism is provided to rinse or fill test tubes in one set of pockets while test tubes in another set of pockets are involved in the dipping process via the dipping mechanism. The carousel member is temperature-controlled such that all of the test tubes when present in the pockets are at substantially the same temperature for critical stages of the testing process. Methods for conducting pharmaceutical product release rate testing using the device are also disclosed.

Abstract: Brush head for cleaning a vessel and use in an automatic dissolution vessel cleaning apparatus which includes a rotatable shaft defining a through passage, an upper end of which is operatively connected to a vacuum source, an inflow housing having at least one channel through which cleaning fluid is pumped and to which the shaft is rotatably mounted, and a brush assembly mounted on the shaft below the housing such that a lower end of the passage is situated below the brush assembly. In use, when the brush head is inserted into the vessel, cleaning fluid is directed through the channel(s) into the vessel while the shaft rotates causing the brush assembly to rotate and clean an inner wall of the vessel with fluid in the vessel being drawn into the passage via its lower end upon coupling of its upper end to the vacuum source.

Abstract: A financial scenario modeling and analysis tool, including a graphical user interface which enables a user of the tool to create a graphical model of a financial scenario, generally including at least one financial transaction, on a display screen, and an engine operable, in response to creation of the graphical model, to automatically generate information, such as financial or mathematical information, which at least partially models at least a part of the financial scenario using information collected by the engine during creation of the graphical model. The graphical user interface enables the user to create party graphics respectively representing parties to the financial deal, and to generate financial instrument graphics representing financial instruments, wherein each financial instrument graphic connects two of the party graphics.

Abstract: Pharmaceutical product release rate testing device includes a base, at least one carousel member rotatably mounted on the base, each carousel member including a plurality of test tube pockets each adapted to receive a test tube fillable with test media, and a dipping mechanism for dipping samples to be tested into the test tubes when present in the pockets and filled with test media. A rinsing/filling mechanism is provided to rinse or fill test tubes in one set of pockets while test tubes in another set of pockets are involved in the dipping process via the dipping mechanism. The carousel member is temperature-controlled such that all of the test tubes when present in the pockets are at substantially the same temperature for critical stages of the testing process. Methods for conducting pharmaceutical product release rate testing using the device are also disclosed.

Abstract: Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.

Abstract: Brush head for cleaning a vessel and use in an automatic dissolution vessel cleaning apparatus which includes a rotatable shaft defining a through passage, an upper end of which is operatively connected to a vacuum source, an inflow housing having at least one channel through which cleaning fluid is pumped and to which the shaft is rotatably mounted, and a brush assembly mounted on the shaft below the housing such that a lower end of the passage is situated below the brush assembly. In use, when the brush head is inserted into the vessel, cleaning fluid is directed through the channel(s) into the vessel while the shaft rotates causing the brush assembly to rotate and clean an inner wall of the vessel with fluid in the vessel being drawn into the passage via its lower end upon coupling of its upper end to the vacuum source.

Abstract: A financial scenario modeling and analysis tool, including a graphical user interface which enables a user of the tool to create a graphical model of a financial scenario, generally including at least one financial transaction, on a display screen, and an engine operable, in response to creation of the graphical model, to automatically generate information, such as financial or mathematical information, which at least partially models at leat a part of the financial scenario using information collected by the engine during creation of the graphical model. The graphical user interface enables the user to create party graphics respectively representing parties to the financial deal, and to generate financial instrument graphics representing financial instruments, wherein each financial instrument graphic connects two of the party graphics.

Abstract: Dissolution sample transfer device for transferring dissolution samples from dissolution vessels to vials including a transfer module housing, a rack defining receptacles receivable of vials, a delivery head arranged in connection with the housing and movable relative to the rack, needles mounted on the delivery head and defining a flow passage to a tip thereof, and a conduit system arranged in connection with the housing for providing conduits for flow of dissolution samples from dissolution vessels to the needles. The needles are movable upon movement of the delivery head to position the tips of the needles to condition filters and wash sample lines or immediately above or in vials when received in the receptacles in the rack. It is possible to automatically transfer the dissolution samples from dissolution vessels to vials which can be handled by a sample arm of an analysis device, e.g., grasped directly from the rack.

Abstract: A financial scenario modeling and analysis tool, including a graphical user interface which enables a user of the tool to create a graphical model of a financial scenario, generally including at least one financial transaction, on a display screen, and an engine operable, in response to creation of the graphical model, to automatically generate information, such as financial or mathematical information, which at least partially models at least a part of the financial scenario using information collected by the engine during creation of the graphical model. The graphical user interface enables the user to create party graphics respectively representing parties to the financial deal, and to generate financial instrument graphics representing financial instruments, wherein each financial instrument graphic connects two of the party graphics.

Abstract: The present invention relates to a functionally integrated microanalytical system for performing fluorescence spectroscopy. A source of fluorescence-exciting radiation, typically a LED, is integrated onto a substrate along with a photodetector and, in some embodiments, an optical filter. A pixel-to-point laser lift-off process is used to effect this component integration. For those cases in which a filter is required, a thin film bandgap filter is typically used, such as CdS or CdSxSe1-x (0<x<1). A disposable microchannel containing the sample and its fluorescent tag is mounted onto the integrated assembly of LED, photodetector and (optionally) filter. This configuration of components allows the microchannel and sample to be readily removed and replaced, facilitating rapid analysis of multiple samples. Multiple LEDS, detectors and filters (if present) can also be integrated onto the same substrate, permitting multiple wavelength analysis of the sample to be performed concurrently.

Abstract: A method and/or system using a nanogap capacitor device and methods for construction of the same.

Abstract: Air bath dissolution tester has a heating element within the USP specification dissolution test stirring shaft, easily attachable to a basket-type (USP) method I, or paddle (USP method II). This allows direct heat transfer to the test solution in the vessel, reducing heat up time. Temperature in the vessel is controlled by a controller responsive to test vessel temperature sensor. Temperature data is obtained during the test. The test vessel is located in a warm air chamber to prevent heat loss. The air chamber and test vessel are transparent, allowing the operator to determine the progress of the test. No water bath is required. The heated SS shaft promotes test solution degassing by direct heating and high-speed stirring during heat up, thus eliminating a separate step.