Patents by Inventor Luke Masterson

Luke Masterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptidomimetic compounds and antibody-drug conjugates thereof
    Patent number: 11692043
    Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: July 4, 2023
    Assignees: MEDIMMUNE LIMITED, GENENTECH, INC.
    Inventors: John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben, Philip Wilson Howard, Luke Masterson
  • Pyrrolobenzodiazepine conjugates
    Patent number: 11649250
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: May 16, 2023
    Assignee: MEDIMMUNE LIMITED
    Inventors: Nazzareno Dimasi, Philip Wilson Howard, Luke Masterson, Arnaud Charles Tiberghien, Balakumar Vijayakrishnan, Jason White
  • PYRROLOBENZODIAZEPINE ANTIBODY CONJUGATES
    Publication number: 20230143309
    Abstract: A conjugate of formula I: L-(DL)p??(I) wherein L is a Ligand unit, DL is a Drug Linker unit of formula II: wherein either: (a) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b) R11 is OH, and R10 is: p is an integer of from 1 to 20.
    Type: Application
    Filed: October 10, 2022
    Publication date: May 11, 2023
    Inventors: Philip Wilson Howard, Elizabeth Dunny, Luke Masterson
  • Pyrrolobenzodiazepine antibody conjugates
    Patent number: 11517626
    Abstract: A conjugate of formula I: L-(DL)P??(1) wherein L is a Ligand unit, DL is a Drug Linker unit of formula II: wherein either: (a) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b) R11 is OH, and R10 is: p is an integer of from 1 to 20.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: December 6, 2022
    Assignee: MEDIMMUNE LIMITED
    Inventors: Philip Wilson Howard, Elizabeth Dunny, Luke Masterson
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20220298161
    Abstract: Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
    Type: Application
    Filed: January 27, 2022
    Publication date: September 22, 2022
    Inventors: Philip Wilson HOWARD, Luke MASTERSON, Arnaud TIBERGHIEN, John A. FLYGARE, Janet L. GUNZNER, Paul POLAKIS, Andrew POLSON, Helga E. RAAB, Susan D. SPENCER
  • Compounds and conjugates thereof
    Patent number: 11446292
    Abstract: A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: September 20, 2022
    Assignee: MedImmune Limited
    Inventors: Philip Wilson Howard, Niall Dickinson, Thais Cailleau, Luke Masterson, William Goundry
  • COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20220211863
    Abstract: A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 7, 2022
    Inventors: Philip Wilson Howard, Niall Dickinson, Thais Cailleau, Luke Masterson, William Goundry
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20210380605
    Abstract: A compound of formula (I) and salts and solvates thereof, wherein RL is a linker for connection to a cell binding agent, which is formula (IIa) wherein Q is a tripeptide residue of formula (A), where x is 1 or 2, —C(?O)-Qx-NH— is a dipeptide residue; X is: formula (B), where a=0 to 5, b=0 to 16, c=0 or 1, d=0 to 5; and GL is a linker for connecting to a Ligand Unit.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 9, 2021
    Inventors: Philip Wilson HOWARD, Ian HUTCHINSON, Luke MASTERSON
  • COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20210322401
    Abstract: A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.
    Type: Application
    Filed: June 15, 2021
    Publication date: October 21, 2021
    Inventors: Philip Wilson HOWARD, Niall DICKINSON, Thais CAILLEAU, Luke MASTERSON, William GOUNDRY
  • Pyrrolobenzodiazepines and conjugates thereof
    Patent number: 11135303
    Abstract: A conjugate of formula (A): where Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety; RL1 and RL2 are independently selected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group; CBA represents a cell binding agent; Q is independently selected from O, S and NH; R11 is either H, or R or, where Q is O, SO3M, where M is a metal cation.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: October 5, 2021
    Assignee: Medimmune Limited
    Inventors: John A. Flygare, Janet L. Gunzner-Toste, Thomas Pillow, Philip Wilson Howard, Luke Masterson
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20210283141
    Abstract: A conjugate of formula I: wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain and each of RLL1 and RLL2 comprise the group:
    Type: Application
    Filed: May 24, 2019
    Publication date: September 16, 2021
    Inventors: Luke MASTERSON, Balakumar VIJAYAKRISHNAN, Ronald James CHRISTIE
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20210187117
    Abstract: A conjugate of formula (I), wherein L is a Ligand unit, D is a Drug Linker unit of formula (II), wherein either: (a) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (b) R10 is OH, and R11 is formula (A): p is an integer of from 1 to 20.
    Type: Application
    Filed: February 10, 2017
    Publication date: June 24, 2021
    Inventors: Philip Wilson Howard, Elizabeth Dunny, Luke Masterson
  • COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20200306243
    Abstract: A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an antibody. Also provided is A* with the linking unit attached, and intermediates for their synthesis, as well as the released warhead.
    Type: Application
    Filed: March 23, 2020
    Publication date: October 1, 2020
    Inventors: Philip Wilson Howard, Niall Dickinson, Thais Cailleau, Luke Masterson, William Goundry
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20200289660
    Abstract: A conjugate of formula I, wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Application
    Filed: November 13, 2018
    Publication date: September 17, 2020
    Inventors: Philip Wilson HOWARD, Luke MASTERSON, Thais CAILLEAU, Nazzareno DIMASI, Jason WHITE
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20200247823
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 6, 2020
    Inventors: Nazzareno DIMASI, Philip Wilson HOWARD, Luke MASTERSON, Arnaud Charles TIBERGHIEN, Balakumar VIJAYAKRISHNAN, Jason WHITE
  • Pyrrolobenzodiazepine conjugates
    Patent number: 10695439
    Abstract: A conjugate of formula (I): L-(DL)p (I) wherein L is a Ligand unit, D is a Drug Linker unit of formula (II) wherein p is an integer of from 1 to 20.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: June 30, 2020
    Assignee: Medimmune Limited
    Inventors: Philip Wilson Howard, Luke Masterson
  • PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF
    Publication number: 20200157240
    Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 21, 2020
    Inventors: John FLYGARE, Janet GUNZNER-TOSTE, Thomas PILLOW, Brian SAFINA, Vishal VERMA, Binqing WEI, Guiling ZHAO, Leanna STABEN, Philip Wilson HOWARD, Luke MASTERSON
  • Peptidomimetic compounds and antibody-drug conjugates thereof
    Patent number: 10533058
    Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: January 14, 2020
    Assignees: Genentech Inc., Medimmune Limited
    Inventors: John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben, Philip Wilson Howard, Luke Masterson
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20190125893
    Abstract: A conjugate of formula (I): L-(DL)p (I) wherein L is a Ligand unit, D is a Drug Linker unit of formula (II) wherein p is an integer of from 1 to 20.
    Type: Application
    Filed: February 10, 2017
    Publication date: May 2, 2019
    Inventors: Philip Wilson Howard, Luke Masterson
  • PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
    Publication number: 20180134717
    Abstract: Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
    Type: Application
    Filed: October 4, 2017
    Publication date: May 17, 2018
    Inventors: Philip Wilson HOWARD, Luke Masterson, Arnaud Tiberghien, John A. Flygare, Janet L. Gunzner, Paul Polakis, Andrew Polson, Helga E. Raab, Susan D. Spencer