Patents by Inventor Luke Masterson

Luke Masterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLOBENZODIAZEPINES
    Publication number: 20110201803
    Abstract: The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: R2 is CHR2A, and R2A is independently selected from H, R, CO2R, COR, CHO, CO2H, and halo; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R7 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R8 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R is independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; or the compound is a dimer with each monomer being of formula (M), where the R7 groups or R8 groups of each monomer form together a dimer bridge having the formula —X—R?—X— linking the monomers; wherein R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), and/or aromatic rings, e.g.
    Type: Application
    Filed: October 16, 2009
    Publication date: August 18, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Zhizhi Chen, Arnaud Charles Tiberghien, Luke Masterson
  • UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20110196148
    Abstract: Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables R12 and R2 represent. Formula (I), wherein: R2 is of formula (II), where A is a C5-7 aryl group, X is selected from the group comprising: OH, SH, CO2H, COH, N?C?O, NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl, and (OC2H4)mOCH3, where m is 1 to 3, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and —Z—(CH2)m—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is —CH?CH—, and Q2 is a single bond; R12 is a C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene. The other variables are as defined in the claims. The compounds are useful for the treatment of proliferative diseases.
    Type: Application
    Filed: October 16, 2009
    Publication date: August 11, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Luke Masterson
  • PYRROLOBENZODIAZEPINES
    Publication number: 20110162227
    Abstract: Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios.
    Type: Application
    Filed: July 22, 2009
    Publication date: July 7, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Zhizhi Chen, Arnaud Charles Tiberghien, Luke Masterson
  • Synthesis of protected pyrrolobenzodiazepines
    Patent number: 7429658
    Abstract: A method of synthesis of a N-10 protected PBD compound of formula (I): via an intermediate of formula (II) or formula (V):
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 30, 2008
    Assignee: Spirogen Limited
    Inventors: Philip Howard, Luke Masterson
  • Synthesis of protected pyrrolobenzodiazepines
    Publication number: 20060264622
    Abstract: A method of synthesis of a N-10 protected PBD compound of formula (I): via an intermediate of formula (II) or formula (V):
    Type: Application
    Filed: September 10, 2004
    Publication date: November 23, 2006
    Applicant: Spirogen Limited
    Inventors: Philip Howard, Luke Masterson