Patents by Inventor Luppo Edens

Luppo Edens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10413599
    Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: September 17, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
  • Patent number: 10196630
    Abstract: The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 ?m. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: February 5, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Aida Hiseni, Igor Galaev, Luppo Edens
  • Patent number: 10172375
    Abstract: An edible composition comprising peptides rich in tryptophan, which edible composition further comprises a rapidly available glucose composition and a slowly available glucose composition.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: January 8, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Rudolf Van Beck-hoven, Alexander Duchateau, Luppo Edens, Franciscus Kleinherenbrink, Joris Kloek, Andre L. Ross De
  • Publication number: 20180177205
    Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 28, 2018
    Inventors: Petrus Jacobus Theodorus DEKKER, Luppo EDENS, Maximiliaan Peter Marie SWAAF, Albertus Alard VAN DIJK
  • Patent number: 9993515
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: June 12, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andre Leonardus De Roos, Luppo Edens, Rudolf Franciscus Van Beckhoven, Alexander Lucia Leonardus Duchateau, Joris Kloek
  • Patent number: 9986751
    Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 5, 2018
    Assignees: DSM IP ASSETS B.V., NOVOZYMES A/S
    Inventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
  • Patent number: 9770493
    Abstract: The present disclosure relates to a composition, and method thereof, which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: September 26, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Cinderella Christina Gerhardt, Luppo Edens
  • Publication number: 20160346364
    Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed.
    Type: Application
    Filed: December 11, 2014
    Publication date: December 1, 2016
    Inventors: Maaike Johanna BRUINS, Luppo EDENS, Lenneke NAN
  • Publication number: 20160302446
    Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers.
    Type: Application
    Filed: December 11, 2014
    Publication date: October 20, 2016
    Inventors: Maaike Johanna BRUINS, Luppo EDENS, Nan LENEKE
  • Publication number: 20160175457
    Abstract: The present invention relates to a composition, such as a coating composition, comprising a peptide linked to a lubricant, wherein the peptide is cleavable by one or more proteinases present in tear fluid. The invention further relates to an ocular device comprising said composition, such as a preformed contact lens.
    Type: Application
    Filed: September 12, 2014
    Publication date: June 23, 2016
    Applicant: DSM IP ASSETS B.V.
    Inventors: Luppo EDENS, Peter Jan Leonard Mario QUAEDFLIEG, James P. PARAKKA, Petrus Johannes HERMSEN, Dennis HEEMSKERK, Michiel AKEROYD
  • Publication number: 20160102300
    Abstract: The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 ?m. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 14, 2016
    Inventors: Aida HISENI, Igor GALAEV, Luppo EDENS
  • Publication number: 20160082070
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Inventors: Andre Leonardus DE ROOS, Luppo EDENS, Rudolf Franciscus VAN BECKHOVEN, Alexander Lucia Leonardus DUCHATEAU, Joris KLOEK
  • Patent number: 9228219
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 5, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andre Leonardus De Roos, Luppo Edens, Rudolf Franciscus Van Beckhoven, Alexander Lucia Leonardus Duchateau, Joris Kloek
  • Publication number: 20150307823
    Abstract: The present invention relates to a process for the preparation of a beverage comprising adding a proline-specific protease and a polyphenoloxidase to the beverage, and preparing the beverage, and a beverage obtainable by the process of the present invention.
    Type: Application
    Filed: December 10, 2013
    Publication date: October 29, 2015
    Applicant: DSM IP ASSETS B.V.
    Inventors: Johanna Henrica Gerdina Maria MUTSAERS, Luppo EDENS, Wilbert Herman Marie HEIJNE
  • Publication number: 20150299057
    Abstract: The present invention relates to a seed treatment composition comprising a waterborne resin and a water dispersible plant protein. The invention is further directed to the production of these compositions and to the uses of these compositions.
    Type: Application
    Filed: November 21, 2013
    Publication date: October 22, 2015
    Inventors: Jurgen SCHEERDER, Gerardus Cornelis OVERBEEK, Luppo EDENS
  • Publication number: 20150208682
    Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
    Type: Application
    Filed: April 10, 2015
    Publication date: July 30, 2015
    Inventors: Petrus Jacobus Theodorus DEKKER, Luppo EDENS, Maximiliaan Peter Marie SWAAF, Albertus Alard VAN DIJK
  • Publication number: 20150201663
    Abstract: The present invention relates to a protein hydrolysate, wherein the hydrolysate has a percentage of peptides having a histidine residue at the C-terminal end of at least 10 wt % of the total peptide content of the protein hydrolysate and a process for preparing the protein hydrolysate. The invention further relates to a food or feed product comprising the protein hydrolysate.
    Type: Application
    Filed: August 13, 2013
    Publication date: July 23, 2015
    Inventors: Andre Leonardus De Roos, Jing Shi, Luppo Edens
  • Publication number: 20150147365
    Abstract: The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).
    Type: Application
    Filed: May 13, 2013
    Publication date: May 28, 2015
    Inventors: Luppo Edens, Evert Tjeerd Van Rij, Marco Jan Lambertus De Groot
  • Patent number: 9011948
    Abstract: Process for producing a dairy product by adding a lactase to a dairy product which contains lactose, the lactase added having less than 40 units arylsulfatase activity per NLU of lactase activity.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: April 21, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Maximiliaan Peter Marie De Swaaf, Albertus Alard Van Dijk
  • Patent number: 8986773
    Abstract: A process to prepare packaged pasteurized or sterilized aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: March 24, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Rudolf Beckhoven Van, Arjen Bot, Alexander Duchateau, Luppo Edens, Joris Kloek, Andre L Ross De