Patents by Inventor Luppo Edens

Luppo Edens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11576394
    Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: February 14, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Maximiliaan Peter Marie De Swaaf, Albertus Alard Van Dijk
  • Patent number: 10413599
    Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: September 17, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
  • Patent number: 10196630
    Abstract: The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 ?m. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: February 5, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Aida Hiseni, Igor Galaev, Luppo Edens
  • Patent number: 10172375
    Abstract: An edible composition comprising peptides rich in tryptophan, which edible composition further comprises a rapidly available glucose composition and a slowly available glucose composition.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: January 8, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Rudolf Van Beck-hoven, Alexander Duchateau, Luppo Edens, Franciscus Kleinherenbrink, Joris Kloek, Andre L. Ross De
  • Patent number: 9993515
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: June 12, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andre Leonardus De Roos, Luppo Edens, Rudolf Franciscus Van Beckhoven, Alexander Lucia Leonardus Duchateau, Joris Kloek
  • Patent number: 9986751
    Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 5, 2018
    Assignees: DSM IP ASSETS B.V., NOVOZYMES A/S
    Inventors: Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
  • Patent number: 9770493
    Abstract: The present disclosure relates to a composition, and method thereof, which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: September 26, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Cinderella Christina Gerhardt, Luppo Edens
  • Patent number: 9228219
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 5, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Andre Leonardus De Roos, Luppo Edens, Rudolf Franciscus Van Beckhoven, Alexander Lucia Leonardus Duchateau, Joris Kloek
  • Publication number: 20150201663
    Abstract: The present invention relates to a protein hydrolysate, wherein the hydrolysate has a percentage of peptides having a histidine residue at the C-terminal end of at least 10 wt % of the total peptide content of the protein hydrolysate and a process for preparing the protein hydrolysate. The invention further relates to a food or feed product comprising the protein hydrolysate.
    Type: Application
    Filed: August 13, 2013
    Publication date: July 23, 2015
    Inventors: Andre Leonardus De Roos, Jing Shi, Luppo Edens
  • Publication number: 20150147365
    Abstract: The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).
    Type: Application
    Filed: May 13, 2013
    Publication date: May 28, 2015
    Inventors: Luppo Edens, Evert Tjeerd Van Rij, Marco Jan Lambertus De Groot
  • Patent number: 9011948
    Abstract: Process for producing a dairy product by adding a lactase to a dairy product which contains lactose, the lactase added having less than 40 units arylsulfatase activity per NLU of lactase activity.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: April 21, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Maximiliaan Peter Marie De Swaaf, Albertus Alard Van Dijk
  • Patent number: 8986773
    Abstract: A process to prepare packaged pasteurized or sterilized aqueous drinkable products which comprise casein micelles (e.g. from dairy protein) and peptide-fractions, which peptide fractions are rich in tryptophan, and the products so-obtained. The process requires a heat preservation at a specific pH.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: March 24, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Rudolf Beckhoven Van, Arjen Bot, Alexander Duchateau, Luppo Edens, Joris Kloek, Andre L Ross De
  • Patent number: 8802088
    Abstract: The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: August 12, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Cinderalla C. Gerhardt, Luppo Edens
  • Publication number: 20130231278
    Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
    Type: Application
    Filed: October 31, 2012
    Publication date: September 5, 2013
    Applicant: DSM IP Assets B.V.
    Inventors: Andre Leonardus De Roos, Luppo Edens, Rudolf Franciscus Van Beckhoven, Alexander Lucia Leonardus Duchateau, Joris Kloek
  • Patent number: 8524225
    Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: September 3, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Luppo Edens, Melissa Harvey, Robertus Antonius Mijndert Van Der Hoeven, Andre Leonardus De Roos
  • Patent number: 8257760
    Abstract: The invention relates to a method for the prevention or reduction of haze in a beverage by the addition of a prolyl-specific and/or alamine specific endoprotease and the new beverages obtainable by the method according to the invention. It also relates to new endoproteases. It also relates to methods as described above wherein auxiliary enzymes are used in combination with the specific endoprotease. Sequence information of a genomic DNA, cDNA as well as protein sequences are provided.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: September 4, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Luppo Edens, Michel Lopez
  • Publication number: 20120141628
    Abstract: The invention relates to a method for the prevention or reduction of haze in a beverage by the addition of an prolyl-specific endoprotease and to new beverages obtainable by the method according to the invention. It also relates to new endoproteases. Sequence information of a genomic DNA, cDNA as well as protein sequences.
    Type: Application
    Filed: January 13, 2012
    Publication date: June 7, 2012
    Applicant: DSM IP Assets B.V.
    Inventors: Michel LOPEZ, Luppo Edens
  • Publication number: 20120107847
    Abstract: We describe a method to determine effectiveness of a compound or composition in treatment of celiac disease or gluten intolerance, the method comprising: administration of the compound or composition to one or more human patients who were on a gluten-free diet for 10 years or less, preferably 6 years or less; challenge with gluten of the one or more human patients who were administered the compound or composition; and determining whether there is a change in condition of celiac disease or gluten intolerance of the one or more patients that results from administration of the compound or composition and challenge with gluten; whereby no significant change in condition indicates that the compound or composition would be effective in treating celiac disease or gluten intolerance.
    Type: Application
    Filed: June 24, 2010
    Publication date: May 3, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventors: Maaike Johanna Bruins, Luppo Edens
  • Patent number: 8119171
    Abstract: The invention relates to a method for the prevention or reduction of haze in a beverage by the addition of an prolyl-specific endoprotease and to new beverages obtainable by the method according to the invention. It also relates to new endoproteases. Sequence information of a genomic DNA, cDNA as well as protein sequences.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: February 21, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Michel Lopez, Luppo Edens
  • Patent number: 8088597
    Abstract: A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P- present than -V-P-P- (molar basis) which comprises hydrolysing the protein source to liberate at least 40% of the I-P-P- sequence into the peptide IPP and whereby a proteolytic enzyme is used which cleaves at the carboxy-terminus of proline residues present in the protein source, the enzyme is preferably a proline specific endoprotease or proline specific oligopeptidase, more preferably a proline specific endoprotease, and optionally an amino peptidase.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: January 3, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Andre Leonardus De Roos, Pieter Marinus Van Den Broecke, Luppo Edens