Abstract: A microfluidic flow cell for carrying out an analysis, having a substrate of synthetic material, which has cavities for the formation of channel structures and chambers, wherein the cavities are closed on one side of the substrate by a film adhesively bonded or welded to the substrate, and having a housing component that is produced with a hard and a soft component, which, on the side of the substrate facing away from the film, is connected to the substrate, completing functional sections respectively fulfilling the function of the flow cell. The housing component is formed as a multifunctional part completing more than two functional sections.

Abstract: Described herein are Mpro cysteine protease inhibitors and methods of utilizing such inhibitors in the treatment of diseases, disorders, or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: Described herein are Mpro cysteine protease inhibitors and methods of utilizing such inhibitors in the treatment of diseases, disorders, or conditions. Also described herein are pharmaceutical compositions containing such compounds.

Abstract: A flow cell with a predetermined breaking barrier in a duct region of the flow cell. The flow cell has a cut-out in a substrate of the flow cell, which forms a portion of the duct region and has an opening in a surface of the substrate. The opening is hermetically sealed by a barrier film fused and/or glued to the surface and forming the predetermined breaking barrier. A layer is provided to be arranged over the barrier film. The layer can be stretched into the cut-out on breaking of the barrier film and formation of an access to a duct region section bounded by the barrier film and the layer.

Abstract: A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.

Abstract: A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.

Abstract: A microfluidic device can include a microfluidic circuit that comprises an inlet port, a reagent-containing chamber configured to receive fluid from the inlet port, a non-aqueous-liquid-containing reservoir configured to receive liquid from the chamber, and a droplet-generating region configured to receive and produce droplets of liquid from the reservoir. The circuit can also include first and second valves or frangible members. The first valve or frangible member can have closed position in which fluid is prevented from entering or exiting the chamber therethrough and an open position in which fluid is permitted to enter or exit the chamber therethrough. The second valve or frangible member can have a closed position in which fluid is prevented from flowing between the chamber and the reservoir therethrough and an open position in which fluid is permitted to flow between the chamber and the reservoir therethrough.

Abstract: An aircraft of the type disclosed here includes an aircraft fuselage, a wing assembly, a tail assembly, and a surface structure containing a lightning protection device. The surface structure is arranged on the aircraft fuselage, the wing assembly, and the tail assembly. The lightning protection device has a plurality of electrically conductive elements, which are arranged at least as a group of elements in the surface structure. The electrically conductive elements belonging to a group are arranged parallel to one another, at least in some section or sections, and have different spacings with respect to one another, at least in two regions.

Abstract: A system for transferring a sample from a sample recovery or provision device to a microfluidic processing device, more particularly an analysis device, preferably in the form of a flow cell, with a sample carrier that removes the sample from the sample recovery or provision device and can be transported to the processing device. The sample carrier can be connected to the sample recovery or provision device and can be detached from sample recovery or provision device, with the sample being automatically removed. The sample carrier connected to the sample recovery or provision device is preferably a functional component of the sample recovery or provision device, more particularly the sample carrier closes a container space of the sample recovery or provision device for receiving sample material.

Abstract: A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent.

Abstract: A microfluidic flow cell including an electrode or sensor device which is located inside the flow cell and from which at least one connecting conductor leads to an externally accessible terminal contact. The electrode or sensor device is arranged on an insulated substrate member. The connecting conductor is embedded in the substrate member. The substrate member can be inserted into an opening in the flow cell such that the electrode or sensor device is placed in the flow cell.

Abstract: A flow cell having at least one reservoir region containing a liquid reagent. The reservoir region is delimited by a carrier element introduced into an opening in the flow cell together with the reagent, wherein the carrier element seals off the reservoir region from the outside in a fluid-tight manner, and has a vessel and/or capillary structure holding the liquid reagent on the carrier element.

Abstract: The present invention refers to NPY Y1 receptor-targeting peptide moieties, and their use for the target-specific treatment of cancers and other diseases.

Abstract: A quick-repair patch for renovating external damage, and quick-repair method for quick repairs of local and structurally mechanically irrelevant damage to aircraft components. The quick-repair patch has a layer structure with a plastic film, to which lightning protection is applied, and an adhesive layer, which is arranged at least on the plastic film. The quick-repair patch can be adhesively bonded to the damage such that the lightning protection is in electrical contact with the lightning protection of the component. The quick-repair patch can have a QR code or an RFID tag, by which specifications relating to the quick-repair patch or to the quick repair can be stored or retrieved.

Abstract: A cartridge for analyzing a biological sample, wherein the cartridge includes a fluid system having a plurality of channels and at least one valve, wherein the valve is covered on the outside by a cover, and wherein the valve is configured to be actuated by deforming a wall of the valve.

Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.

Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.

Abstract: A coating material for a lightning-prone object includes a base color substance and an additive admixed with the base color substance. The additive comprises rigid hollow beads filled with an inert gas. At least a portion of the hollow beads have an electrically conductive coating.

Abstract: A cartridge for analyzing a biological sample, wherein the cartridge includes a fluid system having a plurality of channels and at least one valve, wherein the valve is covered on the outside by a cover, and wherein the valve is configured to be actuated by deforming a wall of the valve.

Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.