Abstract: The present invention provides a compound of Formula I: wherein R1 is hydrogen or methyl; and R2 is: or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: An adapter system is provided that facilitates convenient access to one or more adapters, e.g., DVI-D to HDMI adapter(s), Micro-HDMI to HDMI adapter(s), Mini-HDMI to HDMI adapter(s), Mini-DisplayPort to HDMI adapter(s), DisplayPort to HDMI adapter(s), VGA to HDMI adapter(s), MHL to HDMI adapter(s), and/or USB to HDMI adapter(s). The adapter system includes an elongated wire that features a plurality of adapters connected/secured with respect thereto. The wire defines an attachment mechanism at a first end thereof. The attachment mechanism allows the wire to be movably secured with respect to a cable, e.g., an HDMI cable. In exemplary embodiments, movement of the wire relative to the cable is limited by stop(s) positioned on or defined by the cable. In use, the disclosed adapter system permits a user to readily access and individually utilize each of the adapter(s) connected/secured with respect to the wire on an as-needed basis.

Abstract: Vehicle monitoring systems and methods are described. According to one aspect, a vehicle monitoring system includes a plurality of vehicle monitoring devices individually configured to communicate with circuitry of a respective one of a plurality of vehicles being monitored by the vehicle monitoring system, to receive vehicle information regarding the one vehicle from the circuitry of the one vehicle at a plurality of moments in time, and to output a plurality of messages externally of the vehicle monitoring device at a plurality of moments in time, wherein the messages from the vehicle monitoring devices include the vehicle information being monitored by the vehicle monitoring system, and a management device configured to receive the messages and the vehicle information included within the messages, to store the vehicle information, to process the vehicle information, and to generate and output a communication regarding the vehicles to a recipient party.

Abstract: The present invention provides a compound of Formula I: wherein R1 is hydrogen or methyl; and R2 is: or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: The efficiency of ion exchange processes is increased by increasing the concentration of nitrite salts in the molten salt bath. The increase in nitrite salt concentration may be achieved by adding a nitrite salt to a molten nitrate salt bath, aging a molten nitrate salt bath, or a combination thereof. The glass-based articles produced using the modified baths exhibit reduced haze and increased flexural strength.

Abstract: Methods for reducing a defective area in a strengthened substrate to produce a non-defective substrate are provided. The methods include contacting a strengthened defective substrate with a heated salt bath containing at least one monovalent salt, and removing the strengthened substrate from the bath. The strengthened substrate, before being contacted with the salt bath, is a defective substrate having at least one defective area and one or more non-defective area. Upon removal from the salt bath, at least one defective area has been reduced or substantially removed to produce a non-defective substrate.

Abstract: A glass exhibiting non-frangible behavior in a region where substantially higher central tension is possible without reaching frangibility is provided. This region allows greater extension of the depth of compression in which fracture-causing flaws are arrested, without rendering the glass frangible despite the presence of high central tension region in the sample.

Abstract: A medical device that includes a shaft having a distal end and a cap at the distal end that defines a reservoir for storing a material. The medical device includes a deployment mechanism configured to eject the material from the reservoir, and the deployment mechanism is configured to apply a force to the reservoir. The cap includes a seal or a perforation that is configured to contain the material in the reservoir in the absence of the force applied by the deployment mechanism to the material.

Abstract: The present invention provides a compound of Formula I: wherein R1 is hydrogen or methyl; and R2 is: or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

Abstract: An adapter system is provided that facilitates convenient access to one or more adapters, e.g., DVI-D to HDMI adapter(s), Micro-HDMI to HDMI adapter(s), Mini-HDMI to HDMI adapter(s), Mini-DisplayPort to HDMI adapter(s), DisplayPort to HDMI adapter(s), VGA to HDMI adapter(s), MHL to HDMI adapter(s), and/or USB to HDMI adapter(s). The adapter system includes an elongated wire that features a plurality of adapters connected/secured with respect thereto. The wire defines an attachment mechanism at a first end thereof. The attachment mechanism allows the wire to be movably secured with respect to a cable, e.g., an HDMI cable. In exemplary embodiments, movement of the wire relative to the cable is limited by stop(s) positioned on or defined by the cable. In use, the disclosed adapter system permits a user to readily access and individually utilize each of the adapter(s) connected/secured with respect to the wire on an as-needed basis.

Abstract: An adapter system is provided that facilitates convenient access to a plurality of adapters, e.g., DVI-D to HDMI adapter(s), Micro-HDMI to HDMI adapter(s), Mini-HDMI to HDMI adapter(s), Mini-DisplayPort to HDMI adapter(s), DisplayPort to HDMI adapter(s), VGA to HDMI adapter(s), MNL to HDMI adapter(s), and/or USB to HDMI adapter(s). The adapter system includes an elongated wire that features a plurality of adapters mounted/secured with respect thereto. The wire is at least partially stored within a housing and extends therefrom. The adapters are mounted/secured with respect to a portion of the wire that extends from the housing. The housing includes a retraction mechanism that facilitates retraction of the wire into the housing for convenient storage thereof. The present disclosure further provides structures that are configured and dimensioned to receive the disclosed housing, e.g.

Abstract: A delivery system for delivering a stent to a body lumen. The delivery system includes a tubular member having an expandable stent disposed about the outer surface of the inner tubular member. The stent is maintained in a radially compressed configuration with a removable sheath. The sheath can be released using a variety of techniques.

Abstract: A delivery device may be configured to deliver an agent to a target tissue through a channel of a medical device, the delivery device may include a body including (a) a coupling region configured to removably attach to a handle of the medical device, and (b) a coupler including an exit port for aligning with a port of the channel, wherein the coupler is configured to mate with the port of the channel; a source of an agent; and a source of pressurized fluid. The body, the source of agent, and the source of pressurized fluid may be arranged to deliver agent and pressurized fluid to the exit port for delivery through the channel.

Abstract: A medical device comprising an enclosure defining a cavity for containing agent, a lumen for receiving a pressurized gas, and a barrier positioned between the cavity and the lumen, the barrier including at least one opening for storing agent, wherein rotation of the barrier relative to the lumen establishes fluid communication between the at least one opening and the lumen for delivering agent from the at least one opening to the lumen.

Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.

Abstract: A directional vehicle recovery unit configured for recovery of a distressed vehicle spaced apart from a recovery vehicle is provided. The directional vehicle recovery unit includes a support framework attached to the recovery vehicle and a swing arm assembly attached to the support framework. The swing arm assembly is configured to support a winch cable. The swing arm assembly is rotatable such that with a winch cable attached to the distressed vehicle, a longitudinal axis of the swing arm assembly is substantially parallel with an axis formed by the winch cable.