Abstract: Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A method including loading solar panel assemblies onto a vehicle, transporting the solar panel assemblies on the vehicle to a pile row of a solar project installation site, and individually unloading the solar panel assemblies along the pile row at the installation site to facilitate installation of the solar panel assemblies on the pile row. Other embodiments are described.

Abstract: An apparatus and method for medical imaging uses a first and second contrast agent, the second agent targeted to a particular tissue type. First images are obtained using the first agent, and second images using the second agent using medical imaging systems. An image processing system is adapted to process the first and second medical images by fitting parameters of a pharmacokinetic model to the first medical images, identifying a nontargeted tissue type, scaling the fitted parameters to best match the nontargeted tissue in the second medical images, executing the pharmacokinetic model to prepare a correction image, and generating corrected medical images by subtracting the correction image from the second medical images.

Abstract: Polymeric nanoparticles comprising a defined set of biologically active agents that provide for targeted stimulation of non-responsive T cells, e.g. T cells involved in cancer, are provided.

Abstract: A surgical instrument includes a rotatable electrical coupling assembly having a first part and a second part that electrically couple and rotate relative to each other. The second part is carried by and rotates with a tube collar coupled to a transducer. A portion of the transducer is inserted through an aperture of the second part, but does not contact the second part. The first part of the assembly may electrically couple to the second part via pogo pins, brush contacts, or ball bearings. Alternatively, the first part may comprise conductive channels formed in the casing. The second part may comprise a rotatable drum with a conductive trace. In some versions, one or more components may comprise MID components. In another version, the rotatable electrical coupling assembly comprises a rotatable PC board and brush contact. Further still, a circuit board may be provided with the transducer inside a transducer casing.

Abstract: A plunger for movably mounting within a cavity or barrel of a syringe. The plunger includes a contact face having a flange movably mounted thereto, wherein the flange is movable between an open configuration wherein an opening is formed between the flange and a portion of the plunger, the opening configured for engagement with an IV hook or other engagement member, and a closed configuration wherein the upper surfaces of the contact face and the flange are generally planar with one another.

Abstract: An antigen-specific T cell binding agent is provided, where a multivalent ‘spheromer’ system utilizes a scaffold of a self-assembling polypeptide nanoparticle, for example using selfassembling ferritin polypeptides. The system is compatible with current pMHC reagents, including both MHC-I and MHC-II molecules, and streptavidin reagents that allow ease-of-use. The spheromer assembly pipeline provides a consistent reagent across multiple batches of synthesis with ease of production. The defined geometry of the scaffold allows precise site-directed conjugation of pMHC, leading to a homogenous reagent. The spheromer binds cognate TCRs with a significantly higher avidity than a tetrameric reagent.

Abstract: A suturing system including an elongate distal member and an elongate proximal member proximal the elongate distal member, the elongate proximal member having a lumen. A needle deployment actuator extends to the elongate distal member and is configured to initiate proximal movement of a needle toward an opening of the elongate proximal member. A guide is disposed within the elongate proximal member, a perimeter of the guide forming a plurality of needle receiving gaps that, when viewed in cross-section, are circumferentially spaced about the deployment actuator with a portion of the guide disposed between adjacent needle receiving gaps extending outwardly towards a wall of the lumen of the elongate proximal member.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to use station identification to enable confirmation of exposure to live media. Example apparatus disclosed herein include a watermark data segmenter to determine a media identifier conveyed by a watermark, a detection time determiner to determine a time at which a media meter detected the watermark from a media presentation by a media device, a reference identifier to query a library of reference signatures for a reference signature associated with the media identifier of the watermark and associated with a reference timestamp corresponding to the time at which the media meter detected the watermark, and a viewing type determiner to determine whether the media presentation is live or time-shifted based on whether a result of the query indicates the reference signature does not exist in the library of reference signatures.

Abstract: The present disclosure introduces, among other things, an electronic device, e.g. an integrated circuit (IC). The IC includes a semiconductor substrate comprising a first doped layer of a first conductivity type. A second doped layer of the first conductivity type is located within the first doped layer. The second doped layer has first and second layer portions with a greater dopant concentration than the first doped layer, with the first layer portion being spaced apart from the second layer portion laterally with respect to a surface of the substrate. The IC further includes a lightly doped portion of the first doped layer, the lightly doped portion being located between the first and second layer portions. A dielectric isolation structure is located between the first and second layer portions, and directly contacts the lightly doped portion.

Abstract: A power tool may include a compartment in its housing and a first printed circuit board (PCB) located in the housing and electrically coupled to a first connector. An insertable wireless communication device may include a second electronic processor and an antenna that are each mounted to a second PCB. The insertable wireless communication device may be configured to be received in the compartment and may include a second connector configured to electrically and physically couple to the first connector. The insertable wireless communication device may be configured to wirelessly communicate with an external device. When the insertable wireless communication device is inserted into the compartment, a first conductive layer of the first PCB may be configured to be electrically coupled to the antenna via the first connector and the second connector such that the first conductive layer of the first PCB serves as a ground plane of the antenna.

Abstract: This disclosure is directed to articles of footwear with adjustable dimensions. More specifically, the articles of footwear disclosed herein include sole structures with adjustable dimensions. In some instances, an article of footwear includes one or more removable insert members configured for adjusting the dimensions of a foot-receiving cavity of the article of footwear. Additionally or alternatively, a sole structure can include one or more flexible portions that can move between compressed and expanded states to accommodate feet of various dimensions. To accommodate the adjustable dimensions of the sole structures, an upper of the article of footwear can be stretchable.

Abstract: A communications system may include end-user devices (EUDs), a communications network, and a message processor. A message parser determines, from a received message, a message originator EUD having an associated originator message channel format, and at least one intended message recipient EUD with an associated recipient message channel format. A message channel database includes respective different message channel formats for different EUDs. A message recaster cooperates with the message parser and message channel database and transmits at least one recast message based upon the received message, which may include a corresponding recipient message channel format with a corresponding Internet Protocol (IP) address for the at least one intended recipient EUD.

Abstract: A system for dehydration of organic material comprises a housing structure having an interior chamber, a supply duct, a dual trunk structure, a dry air intake, a central recirculation duct, and a plurality of side recirculation ducts. The side recirculation ducts each have a return plenum extending downward from a top recirculation duct and are configured to recirculate interior air contained in the chamber. The interior air enters the side recirculation ducts through the return plenums and is pushed upward and outward through the top recirculation ducts and back into the interior chamber. The interior chamber has a plurality of exhaust vents positioned in the upper region of its walls. A plurality of portable platforms positioned inside the interior chamber are configured to hold the organic material. The floor of the housing structure can include a plurality of tracks for loading, unloading and positioning the portable platforms.

Abstract: A suturing system including a sheath, a handle assembly proximal the sheath, an elongate body disposed between the sheath and the handle, a plurality of needles disposed distal the elongate body in a pre-deployed configuration and movable into the elongate body in a deployed configuration, each of the plurality of needles including a needle tip, each needle tip being orientated proximally towards the elongate body in the pre-deployed configuration, and a needle capture assembly disposed between a distal end of the elongate body and the handle, the needle capture assembly including two needle engaging edges longitudinally spaced with respect to each other, with each being configured to interlock with at least one of the plurality of needles.

Abstract: A power tool may include a compartment in its housing and a first printed circuit board (PCB) located in the housing and electrically coupled to a first connector. An insertable wireless communication device may include a second electronic processor and an antenna that are each mounted to a second PCB. The insertable wireless communication device may be configured to be received in the compartment and may include a second connector configured to electrically and physically couple to the first connector. The insertable wireless communication device may be configured to wirelessly communicate with an external device. When the insertable wireless communication device is inserted into the compartment, a first conductive layer of the first PCB may be configured to be electrically coupled to the antenna via the first connector and the second connector such that the first conductive layer of the first PCB serves as a ground plane of the antenna.

Abstract: Methods and apparatus are disclosed for supplementing partially readable and/or inaccurate codes. An example apparatus includes a watermark analyzer to select a first watermark and a second watermark decoded from media; a comparator to compare a first decoded timestamp of the first watermark to a second decoded timestamp of the second watermark; and a timestamp adjuster to adjust the second decoded timestamp based on the first decoded timestamp of the second watermark when at least a threshold number of symbols of the second decoded timestamp match corresponding symbols of the first decoded timestamp.

Abstract: A method is provided for locking and unlocking an electronic power tool. The method includes receiving, at a locking device, information associated with the electronic power tool, and generating, at the locking device, a lock code based on the received information. The method further includes transmitting, by the locking device, the lock code to the electronic power tool. The lock code is configured to lock the electronic power tool upon being received at the electronic power tool.