Abstract: A method for automated processing of a cellular product comprising target substrate cells, the method comprising providing a separation apparatus configured to associate with a disposable sterile circuit comprising a separator in communication with the cellular product.

Abstract: The present application provides bifunctional compounds of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 4 (CDK4) and/or cyclin-dependent kinase 6 (CDK6). The present application also relates to methods for the targeted degradation of CDK4 and/or CDK6 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK4 and/or CDK6 which can be utilized in the treatment of disorders modulated by CDK4 and/or CDK6.

Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.

Abstract: A rework re-timer with forward error correction handling is disclosed. An example first intermediate transceiver includes a first interface to communicatively couple the first intermediate transceiver with a first computing device, a second interface to communicatively couple the first intermediate transceiver to a second intermediate transceiver configured to be communicatively coupled with a second computing device, an auto-negotiation controller to: terminate a first auto-negotiation with the first computing device before the first auto-negotiation is completed, transmit, to the second transceiver, first capabilities of the first computing device determined during the first auto-negotiation, and perform a second auto-negotiation with the first computing device utilizing the first capabilities of the first computing device and second capabilities of the second computing device received from the second transceiver.

Abstract: Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer. Also disclosed are methods for inducing immune reaction to androgen receptor or treating prostate cancer in a mammal, using the vaccines and pharmaceutical compositions comprising the vaccines.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: An infusion catheter assembly has the ability to infinitely titrate the length of a porous fluid distribution section in situ. The infusion catheter assembly thereby provides a length of infusion that can be infinitely varied over a prescribed range, to control the effective infusion length and the rate of infusion. Using the infusion catheter assembly, a physician has the capability to treat only the length of the vessel desired, thereby preventing excessive drug/patient exposures. The porous fluid distribution section can include an array of spaced apart apertures that vary in size and/or density along the length of the porous fluid distribution section, such that the flow rate remains essentially constant for a given inlet pressure independent of the effective infusion length.

Abstract: Methods for forming sintered-bonded high temperature coatings over ceramic turbomachine components are provided, as are ceramic turbomachine components having such high temperature coatings formed thereover. In one embodiment, the method includes the step or process of removing a surface oxide layer from the ceramic component body of a turbomachine component to expose a treated surface of the ceramic component body. A first layer of coating precursor material, which has a solids content composed predominately of at least one rare earth silicate by weight percentage, is applied to the treated surface. The first layer of the coating precursor material is then heat treated to sinter the solids content and form a first sintered coating layer bonded to the treated surface. The steps of applying and sintering the coating precursor may be repeated, as desired, to build a sintered coating body to a desired thickness over the ceramic component body.

Abstract: Techniques and apparatuses are described that enable radar modulations for radar sensing using a wireless communication chipset. A controller initializes or controls modulations performed by the wireless communication chipset. In this way, the controller can enable the wireless communication chipset to perform modulations for wireless communication or radar sensing. In some cases, the controller can further select a wireless communication channel for setting a frequency and a bandwidth of a radar signal, thereby avoiding interference between multiple radar signals or between the radar signal and a communication signal. In other cases, the controller can cause the wireless communication chipset to modulate a signal containing communication data using a radar modulation. This enables another device that receives the signal to perform wireless communication or radar sensing. By utilizing these techniques, the wireless communication chipset can be used for wireless communication or radar sensing.

Abstract: An elevatable platform system for mounting on a vehicle having an elevatable platform elevatable by a collapsible support structure. The support structure is adapted to move the elevatable platform between a lowered position in which the elevatable platform is positioned at a height proximate to or below the height of the vehicle and an elevated position in which the elevatable platform is elevated above the vehicle. Support legs integrated into the support structure can be deployed from the support structure when the elevatable platform is elevated to further stabilize the elevated platform.

Abstract: An apparatus for ratio control of a continuously variable transmission includes a driver commanded ratio unit outputting a signal defining a commanded ratio. A clamp control portion is in communication with the driver commanded ratio unit. The clamp control portion includes: a ratio limits and override ring selecting a ratio matching the commanded ratio from an executable functions having stored ratio code data; a screening monitor continuously receiving output from the executable functions and using an input from a vehicle speed signal to compute minimum and maximum ratio limits for the ratio selected by the ratio limits and override ring; and a ratio control execution ring in communication with the screening monitor. The ratio control execution ring calculates a range of pressures allowed for operation of both primary and secondary pulleys of the continuously variable transmission.

Abstract: Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer. Also disclosed are methods for inducing immune reaction to androgen receptor or treating prostate cancer in a mammal, using the vaccines and pharmaceutical compositions comprising the vaccines.

Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality, of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

Abstract: A fluid circuit includes a device, a cooler, and a valve. The valve includes a housing, a sealing member, a biasing device, and an actuator. The sealing member moves inside the housing between a first position and a second position. The actuator includes a smart material that is activated when the temperature of a fluid inside the housing exhibiting at least a first temperature, causing the sealing member to move to the second position. The smart material is deactivated when the fluid is a sufficient number of degrees less than the first temperature, causing the sealing member to move to the first position. The fluid flows from the housing to the device and then to the housing when the sealing member is in the first position. The fluid flows from the housing to the cooler and then to the device when the sealing member is in the second position.

Abstract: An infusion catheter assembly has the ability to infinitely titrate the length of a porous fluid distribution section in situ. The infusion catheter assembly thereby provides a length of infusion that can be infinitely varied over a prescribed range, to control the effective infusion length and the rate of infusion. Using the infusion catheter assembly, a physician has the capability to treat only the length of the vessel desired, thereby preventing excessive drug/patient exposures. The porous fluid distribution section can include an array of spaced apart apertures that vary in size and/or density along the length of the porous fluid distribution section, such that the flow rate remains essentially constant for a given inlet pressure independent of the effective infusion length.

Abstract: A target module determines a target ratio between a speed of an input shaft and a speed of an output shaft of a continuously variable transmission (CVT) based on an accelerator pedal position. A maximum rate of change (ROC) module determines a maximum ROC of the target ratio. A switching valve control module, based on a comparison of the maximum ROC and a ROC of the target ratio, selectively actuates a switching valve of the CVT one of (i) from a closed position to an open position and (ii) from the open position to the closed position. The switching valve prevents transmission fluid flow through a flow path between a transmission fluid pump and a pressure regulator valve of the CVT when the switching valve is in the closed position. The switching valve allows transmission fluid flow through the flow path when the switching valve is in the open position.

Abstract: A hose fitting swaging device may include a base at least two truss rods, first and second die collars and a hydraulic cylinder. The truss rods may be spaced apart from each other and extend upward from the base. Each truss rod may have a proximal end removably secured to the base. Each truss rod may also have a distal end opposite the base. The first die collar may be removably secured to the distal ends of the truss rods. The second die collar may be slideably retained by the truss rods, between the base and the first die collar. The hydraulic cylinder may be removably secured to the base in between the truss rods and beneath the second die collar. Thus, the hydraulic cylinder may be operable to forcibly drive the second die collar upwards, along the truss rods, toward the first die collar. The first die collar may be supported entirely by the truss rods.

Abstract: Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions.