Abstract: In one implementation, a non-transitory computer-readable storage medium stores program instructions computer-executable on a computer to perform operations. The operations include obtaining first content representing a physical environment in which an electronic device is located using an image sensor of the electronic device. A physical feature corresponding to a physical object in the physical environment is detected using the first content. A feature descriptor corresponding to a physical parameter of the physical feature is determined using the first content. Second content representing a computer generated reality (CGR) environment is generated based on the feature descriptor and presented on a display of the electronic device.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: In an exemplary process for selecting a text input field using an eye gaze, a graphical object including the text input field is displayed. The text input field is associated with one or more respective locations on one or more displays. Characteristics of an eye gaze are determined using gaze sensors, and a gaze location is determined using the characteristics. Input is received from an input device corresponding to one or more text characters. If the gaze location corresponds to the one or more respective locations, then the one or more text characters are displayed in the text input field. If the gaze location does not correspond to the one or more respective locations, then the one or more text characters are not displayed in the text input field.

Abstract: The present application provides bifunctional compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8.

Abstract: The present disclosure generally relates to providing product information. The appearance of a first product and a second product is detected within a field of view of one or more image sensors. Movement of the first product or the second product relative to one another is then detected. If the movement of the first product or the second product relative to one another causes the first product to come within a threshold distance of the second product, then comparison information is displayed at a location at least partially between the first product and the second product.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: A method of testing a braking system for an automotive vehicle that includes a master cylinder, a brake booster, a plurality of brake assemblies, a plurality of inlet valves, each inlet valve adapted to selectively allow brake fluid to flow into one of the plurality of brake assemblies and a plurality of outlet valves, each outlet valve adapted to selectively allow brake fluid to flow from one of the brake assemblies to a brake fluid reservoir, the method includes testing a first one of the plurality of inlet valves, testing a first one of the plurality of outlet valves, and sending diagnostic information to a controller within the automotive vehicle.

Abstract: The present application provides bifunctional compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 8 (CDK8). The present application also relates to methods for the targeted degradation of CDK8 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to CDK8 which can be utilized in the treatment of disorders modulated by CDK8.

Abstract: A method of processing blood includes receiving from a touch screen user input data for a protocol for a wash procedure. The user input data includes a numeric value. The method includes storing the protocol in a memory, receiving an identifier from a user, determining if the identifier permits the user to modify the protocol and receiving a modification of the protocol from the user. The method includes providing a plurality of authorizations, a second authorization being a default and an administrator authorization permitting the user to change a setting. The method includes comparing a password to a password stored in memory and, if there is a match, determining that the password is associated with an administrator. If a command to change the setting is received, the command is applied to change the setting. The blood is processed employing a wash procedure using the modified protocol and the changed setting.

Abstract: A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

Abstract: In one implementation, a non-transitory computer-readable storage medium stores program instructions computer-executable on a computer to perform operations. The operations include presenting, on a display of an electronic device, first content representing a standard view of a physical setting depicted in image data generated by an image sensor of the electronic device. While presenting the first content, an interaction with an input device of the electronic device is detected that is indicative of a request to present an enriched view of the physical setting. In accordance with detecting the interaction, second content is formed representing the enriched view of the physical setting by applying an enrichment effect that alters or supplements the image data generated by the image sensor. The second content representing the enriched view of the physical setting is presented on the display.

Abstract: The present application provides bifunctional compounds, or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for cyclin-dependent kinase 4 (CDK4) and/or cyclin-dependent kinase 6 (CDK6).

Abstract: Mesothelin (MSLN) is expressed on pancreatic cancers, ovarian cancers and mesotheliomas. The present disclosure provides antigen-binding molecules, including anti-MSLN antibodies, and bispecific antigen-binding molecules that bind to both MSLN and a T cell antigen (e.g., CD3) and activate T cells in the presence of MSLN-expressing tumor cells. The antigen-binding molecules of this disclosure are useful for the treatment of diseases and disorders in which a MSLN-targeted immune response is desired and/or therapeutically beneficial. For example, the antigen-binding molecules of the present disclosure are useful for the treatment of various cancers, including pancreatic cancer, ovarian cancer and mesotheliomas.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: A cell processing system includes a processor to receive a biological fluid to be processed, a controller coupled to the processor, the controller configured to operate the processor according to at least one modifiable process parameter, and at least one input coupled to the controller, the at least one input configured to receive an identifier and at least one process parameter control associated with the at least one process parameter that limits modification of the at least one process parameter if applied. The controller is configured to determine if the identifier is associated with an administrator authorization and to apply the at least one processor parameter control to the at least one process parameter if the identifier is associated with an administrator authorization.

Abstract: Methods for forming sintered-bonded high temperature coatings over ceramic turbomachine components are provided, as are ceramic turbomachine components having such high temperature coatings formed thereover. In one embodiment, the method includes the step or process of removing a surface oxide layer from the ceramic component body of a turbomachine component to expose a treated surface of the ceramic component body. A first layer of coating precursor material, which has a solids content composed predominately of at least one rare earth silicate by weight percentage, is applied to the treated surface. The first layer of the coating precursor material is then heat treated to sinter the solids content and form a first sintered coating layer bonded to the treated surface. The steps of applying and sintering the coating precursor may be repeated, as desired, to build a sintered coating body to a desired thickness over the ceramic component body.

Abstract: A rotary swivel joint preferably includes a swivel housing, a rotary swivel, an end plate, two sets of sealed bearings, a swivel seal and an O-ring. The swivel housing includes a threaded tube inlet and a swivel receiver bore. The rotary swivel includes a through bore, a threaded swivel inlet, a bearing diameter and a sealing diameter and an outer diameter. An O-ring groove is formed in the bearing diameter to receive the O-ring. The first and second sealed bearing sets are retained on the bearing diameter and axially retained with a plurality of snap rings. The swivel seal is retained on the sealing diameter. The rotary swivel is inserted through a center bore in the end plate. The end plate is preferably fastened to the swivel housing with a plurality of fasteners.

Abstract: In an exemplary process for selecting a text input field using an eye gaze, a graphical object including the text input field is displayed. The text input field is associated with one or more respective locations on one or more displays. Characteristics of an eye gaze are determined using gaze sensors, and a gaze location is determined using the characteristics. Input is received from an input device corresponding to one or more text characters. If the gaze location corresponds to the one or more respective locations, then the one or more text characters are displayed in the text input field. If the gaze location does not correspond to the one or more respective locations, then the one or more text characters are not displayed in the text input field.