Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Ka enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Ka signaling with the compounds and compositions of the disclosure.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

Abstract: Provided is an air-diverter apparatus configured to modify the directional airflow in an aircraft cabin. A nozzle may be provided that includes a body having a longitudinal axis, an inlet configured to be connected to a source of air, a flow passage in communication with the inlet and extending through the body, and an outlet in communication with the flow passage, wherein the outlet is angled relative to the longitudinal axis.

Abstract: Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

Abstract: Systems for facilitating movement of a patient transport apparatus are provided and include user input control device that includes a mode switch selectable between a longitudinal transport mode and a multidirectional mode and a driving assist device actuatable between at least one engaged state and a non-engaged state. The mode switch generates signals based on the selected mode and the driving assist device generates engaged or non-engaged signals which are received by a controller. The controller is configured to generate an output signal sent to a lift actuator, swivel actuator, and/or a powered drive system to assist a user in propelling the apparatus in a desired manner.

Abstract: A foldable bassinet includes an upper bassinet frame, a pair of leg structures opposite to each other, and a bottom board. Each leg structure has an upper tower portion and a lower ledge portion. The upper bassinet frame is disposed through the upper tower portion of each leg structure to make each leg structure pivotable relative to the upper bassinet frame between a supporting position and a folding position. The bottom board is detachably configured between the two lower ledge portions and defines a containing space cooperatively with the upper bassinet frame and the leg structures. When the bottom board is detached from the two lower ledge portions, the leg structures are rotatable from the supporting position to the folding position to be folded inwardly relative to the upper bassinet frame.

Abstract: A space antenna may include an extendible boom movable between stored and deployed positions. An extendible hoop may surround the extendible boom and is movable between the stored and deployed positions. A front cord arrangement may be coupled to the extendible hoop and defines a curved shape in the deployed position, and a reflective layer may be carried thereby. A rear cord arrangement may be behind the front cord arrangement and coupled between the extendible hoop and the extendible boom. The rear cord arrangement may include a rear plurality of interconnected cords defining rear polygons. Tie cords may extend between the front cord arrangement and the rear cord arrangement. A top cord arrangement may be above the reflective layer and coupled between the hoop and the extendible boom.

Abstract: A foldable bassinet includes an upper bassinet frame, a pair of leg structures opposite to each other, and a bottom board. Each leg structure has an upper tower portion and a lower ledge portion. The upper bassinet frame is disposed through the upper tower portion of each leg structure to make each leg structure pivotable relative to the upper bassinet frame between a supporting position and a folding position. The bottom board is detachably configured between the two lower ledge portions and defines a containing space cooperatively with the upper bassinet frame and the leg structures. When the bottom board is detached from the two lower ledge portions, the leg structures are rotatable from the supporting position to the folding position to be folded inwardly relative to the upper bassinet frame.

Abstract: A battery includes a first chamber with a first electrode and a second chamber with a second electrode. An intercalation membrane between the first chamber and the second chamber is configured to retain an electrolyte in the first chamber and to accept therein migrating ions of the electrolyte in the presence of an electrical field and lose mechanical integrity permitting the electrolyte to enter the second chamber in order to activate the battery.

Abstract: A valve repair device for repairing a native valve of a patient can include a coaptationm element. The valve repair device can include a pair of paddles. The coaption element can comprise a fabric. The pair of paddles can be connected to the coaption element. The paddles are movable between an open position and a closed position. The paddles are configured to attach to the native valve of the patient.

Abstract: The present invention concerns a chemical mechanical polishing pad having a polishing layer. The polishing layer contains an extruded sheet. The extruded sheet is a photopolymerizable composition containing a block copolymer, a UV curable acrylate, and a photoinitiator.

Abstract: An apparatus for a bone fusion assembly is provided for compressing adjacent bones across a bone fusion site to encourage fusion thereof. The bone fusion assembly includes a generally elongate member comprising a plate that has one or more fixation apertures to receive fasteners that are configured to be coupled with the adjacent bones. A threaded fastener comprising a bone screw, including a head portion and a shank, is configured to traverse the bone fusion site. A slanted aperture disposed in the plate is configured to receive the bone screw at a predetermined angle with respect to a plane of the plate. The slanted aperture comprises a smooth countersunk surface and one or more teeth that are configured to cooperate with the head portion of the bone screw to compress the adjacent bones together and encourage bone fusion therebetween.

Abstract: Embodiments described herein may be directed to systems, methods, apparatuses, devices, computer program products, computer-executable instructions, and/or applications for securely and anonymously accessing web resources and customizable attribution of identity. In accordance with the present disclosure, a user may inspect and analyze a webpage as well as the underlying source code from an “arm's length” using a secure analysis application to prevent exposure on the user's local machine. The secure analysis application may provide increased flexibility in masking and/or modifying the user's digital persona to external websites.

Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an engineered nucleic acid sequence encoding a functional hSGSH, optionally comprising stabilizing amino acid changes, a regulatory sequence which direct expression of hSGSH in a target cell, and an AAV 3? ITR. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treating a human subject diagnosed with MPS IIIA.

Abstract: A camera testing system for determining performance of a camera comprising an imaging sensor and a lens, the system comprising a processing system comprising at least one processor and memory. The processing system may be configured to: control the camera to capture, using the imaging sensor, a first image through the lens of a target disposed at a first distance from the camera; determine a first modulation transfer function (MTF) value from the first image; control the camera to capture, using the imaging sensor, a second image through the lens of the target disposed at a second distance from the camera that is different from the first distance; determine a second MTF value from the second image; and determine performance of the camera based on the first MTF value, the second MTF value and a difference between the first MTF value and the second MTF value.

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

Abstract: A surgical tool includes a drive housing, an indicator assembly arranged within the drive housing and actuatable to provide visual indication that the surgical tool has exhausted its useful life. The indicator assembly includes a drive input rotatably coupled to the bottom of the drive housing. The drive input further including a riser and a rim where the riser contains a passage therethrough. The indicator assembly further includes an indicator shaft extending through the passage along a longitudinal axis coaxially aligned with the drive input. The drive input is rotated to actuate the indicator assembly between a non-activated state, where the indicator shaft is recessed into the drive housing, and an activated state, where the indicator shaft extends out of the drive housing to provide the visual indication.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: An device for treating a native valve includes a sealing element and an anchoring element. The sealing element is made from a braided mesh material. The sealing element is dimensioned to be deployed in an annulus of a native valve of a heart at a position between native valve leaflets to contact the native valve leaflets during ventricular systole to create a seal to prevent regurgitation of blood from the left ventricle to the left atrium. The sealing element is configured to both be radially expanded and radially reduced while at the position between the native valve leaflets. The anchoring element is adapted for deployment in the heart, the anchoring element coupled to the sealing element and configured to support the sealing element at the desired position between native valve leaflets.

Abstract: An implantable device or implant is configured to be positioned within a native heart valve to allow the native heart valve to form a more effective seal. The implantable device or implant can expand and contract. For example, the implantable device or implant can narrow during delivery and expand on implantation on the native heart valve.