Abstract: Apparatus, systems and methods for monitoring loads on a pallet, each apparatus using one or more force sensors placed under and along a single side of a loaded pallet. In embodiments, each apparatus comprises one or more low profile force sensors in one or more housings mountable on an underlying floor surface, carrying self-contained power supplies and having an associated Bluetooth transceiver. The apparatus force sensors output signals corresponding to pallet loads and load changes. Multiple apparatus may comprise a system including a base station having a Bluetooth transceiver for communicating with each the Bluetooth transceiver of each apparatus.

Abstract: An apparatus may be used with an elongate member that includes an engagement member, a hollow shaft, a compression member, a compression element, and a resilient gripping member. The hollow shaft extends from the engagement member along a longitudinal axis. The compression member is slidably disposed over the hollow shaft. The hollow shaft is disposed over the resilient gripping member and supports the compression element. The compression member has a conical inner surface including a detent feature. The conical inner surface is configured to urge the compression element radially inwards as the collar advances from the unlocked position toward the locked position where the detent feature retains the compression element. The compression element deforms the resilient gripping member radially inwards to grip the elongate member and prevents translation of the elongate member. When unlocked, the resilient gripping member moves radially away from the elongate member allowing translation.

Abstract: An exemplary valve repair device for repairing a native valve of a patient includes a coaption element, a pair of paddles, and barb portions. The barb portions extend directly from at least one of the coaption element and the pair of paddles.

Abstract: A method for replacing a stenotic native aortic valve of a patient can include inserting a delivery apparatus into a femoral artery of the patient, the delivery apparatus having a first shaft extending from the handle, a second shaft disposed around the first shaft, a third shaft extending through the second shaft, and a valve cover coupled to the first shaft. The valve cover can be in a first state housing an entirety of a prosthetic heart valve and retaining the prosthetic heart valve in a radially compressed state during the act of inserting. The method can further include advancing the delivery apparatus through the aorta of the patient to position the valve cover and the prosthetic heart valve within the native aortic valve, and moving the valve cover longitudinally from the first state to a second state in which the entirety of the prosthetic heart valve is uncovered.

Abstract: A device includes a handle, an apparatus for probing and cutting, and an adaptor. The handle includes one or more triggers. The apparatus for probing and cutting is connectable to the handle and includes an elongated member, a probe, and a blade. The probe and the blade are selectively deployable from the elongate member via activation of the one or more triggers on the handle. The adaptor is configured to selectively connect the apparatus to the handle in a predetermined orientation.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: Embodiments of the present disclosure provide a delivery apparatus for a prosthetic heart valve. Disclosed delivery apparatuses can include a handle, a first shaft extending from the handle, a second shaft disposed around the first shaft, and a valve cover. The valve cover can be coupled to a distal end portion of the first shaft and can be configured to house a prosthetic heart valve in a radially compressed state. The valve cover can have an outer diameter greater than an outer diameter of the second shaft, and the first shaft and valve cover can be movable together in an axial direction relative to the second shaft.

Abstract: Devices, systems and/or methods for repairing soft tissue adjacent a soft tissue repair site. In one embodiment, a repair device includes an anchor member, a capture member and one or more flexible members. The anchor member includes a base with at least four legs extending integrally from the base, the at least four legs configured to be moveable from a straight first position to a formed second position. The capture member is configured to be coupled to the anchor member such that the at least four legs of the anchor member move around structural portions of the capture member with the at least four legs of the anchor member in the formed second position. The one or more flexible members are coupled to the base of the anchor member, the one or more flexible members extending at least partially along the base of the anchor member.

Abstract: Devices, systems and/or methods for fixating soft tissue to bone are provided. In one embodiment, a repair device for fixating soft tissue to bone with a bone anchor includes a soft tissue anchor and one or more flexible members. The soft tissue anchor includes a base with multiple legs extending from the base. The one or more flexible members are coupled to the base and configured to extend from the base to the bone anchor with a fixed length. With this arrangement, the fixed length of the one or more flexible members is configured to maintain a fixed distance between the soft tissue anchor and the bone anchor such that, as the bone anchor is seated into bone, the one or more flexible members pulls the soft tissue anchor down against the soft tissue to fixate the soft tissue to the bone.

Abstract: A surgical instrument includes an outer tube configured to be gripped by a user, and a needle slidably disposed within the outer tube. The needle includes a needle lumen, a distal needle tip configured to pierce tissue, and an electrode disposed at the distal needle tip. The needle lumen opens to the distal needle tip such that the distal needle tip is configured to deliver fluid from the needle lumen to tissue. The electrode is operable to deliver RF energy to tissue for ablating the tissue. The needle is translatable relative to the outer tube between a proximal retracted position in which the distal needle tip is housed coaxially within the outer tube, and a distal extended position in which the distal needle tip is exposed from the outer tube and configured to pierce tissue.

Abstract: An image processing system may comprise a global shutter camera, an illumination emitter, and a processing system comprising at least one processor and memory. The processing system may be configured to control the image processing system to: control the illumination emitter to illuminate a scene; control the global shutter camera to capture a sequence of images of the scene, wherein the captured sequence of images includes images that are captured without illumination of the scene by the illumination emitter and images that are captured while the scene is illuminated by the illumination emitter; and determine presence of an object in the scene based on comparison of the images captured without illumination of the scene and images captured with illumination of the scene.

Abstract: A camera testing system for determining performance of a camera comprising an imaging sensor and a lens, the system comprising a processing system comprising at least one processor and memory. The processing system may be configured to: control the camera to capture, using the imaging sensor, a first image through the lens of a target disposed at a first distance from the camera; determine a first modulation transfer function (MTF) value from the first image; control the camera to capture, using the imaging sensor, a second image through the lens of the target disposed at a second distance from the camera that is different from the first distance; determine a second MTF value from the second image; and determine performance of the camera based on the first MTF value, the second MTF value and a difference between the first MTF value and the second MTF value.

Abstract: Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from tyrosine phosphorylated signaling molecules, play equally important tyrosine roles as protein kinases in signal transduction. SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines. Recent studies have clearly demonstrated that this phosphatase plays an important role in transducing signal relay from the cell surface to the nucleus, and is a critical intracellular regulator in mediating cell proliferation and differentiation.

Abstract: The present invention relates to novel compounds having the general formula: and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for suppressing tumor cell growth, ameliorating the pathogenesis of systemic lupus erythematosus, and the treatment of various other disorders, including Noonan syndrome, diabetes, neutropenia, neuroblastoma, melanoma, juvenile leukemia, juvenile myelomonocytic leukemia, chronic myelomonocytic leukemia, acute myeloid leukemia, and other cancers associated with SHP2 deregulation with the compounds and compositions of the invention, alone or in combination with other treatments.

Abstract: A stabilizing unit for a medical device includes a base member, a housing, a stabilizing fork, one or more springs, and a retaining arm. The housing has a lower housing portion and an upper housing portion connected to the lower housing portion. The lower housing portion is disposed in a laterally extending slot of the base member. The stabilizing fork is disposed in the upper housing portion. The one or more springs extend into the stabilizing fork. The retaining arm is slidably coupled to the upper housing portion. The retaining arm retains the stabilizing fork in the upper housing portion.

Abstract: Embodiments of the present disclosure provide an introducer device for introducing a medical device into a patient's vasculature. In one embodiment, the introducer device comprises a housing, a distal sheath adapted to be inserted into a patient's vasculature with the housing positioned outside of the patient's vasculature, a hemostatic seal mounted within the housing, and a tube positioned within the housing and movable longitudinally relative to the hemostatic seal between a proximal position and a distal position. In the proximal position, a distal end of the tube is positioned proximal to the hemostatic seal with the hemostatic seal closed. In the distal position, the distal end of the tube extends through the hemostatic seal and permits the medical device to be inserted through the housing and into the patient's vasculature without contacting the hemostatic seal.

Abstract: In an example, a computer-implemented method to structure an analytical workflow that improves reasoning based on a problem context and demonstrated abilities of each individual user may include displaying a reasoning problem to an analyst. The method may include receiving input from the analyst to identify a reasoning problem type of the reasoning problem. providing a recommended analytic approach for the reasoning problem type to the analyst. The method may include assisting the analyst in analyzing and evaluating one or more information sources relevant to the reasoning problem. The method may include guiding the analyst through a structured technique (ST) to support reasoning of the analyst in formulation of a solution to the reasoning problem. The method may include generating a report that includes the analyst's solution to the reasoning problem based on input from the analyst.

Abstract: A dental water jet is provided. The dental water jet may include a base unit, a reservoir supported by the base unit, a handle supported by the base unit, and a container covering an opening of the reservoir. The container may include a base supported by the reservoir and a lid movable relative to the base. The container may be configured to store one or more tips for use with the handle.

Abstract: The techniques of this disclosure relate to a system for adjusting a focus of an image. A system includes a phased metalens configured to adjust a focus of an image detected by an imaging substrate of an image sensor to compensate for warpage of the imaging substrate. The phased metalens can achieve a near-diffraction-limited focusing over incoming light wavelengths using precisely defined nanoscale subwavelength resolution structures.

Abstract: The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.