Patents by Inventor M. Wolfe

M. Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250135015
    Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: August 9, 2024
    Publication date: May 1, 2025
    Applicants: Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
    Inventors: Justin M. WOLFE, Colin M. FADZEN, Zi-Ning CHOO, Rebecca L. HOLDEN, Monica YAO, Gunnar J. HANSON, Bradley L. PENTELUTE
  • Patent number: 12138312
    Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 12, 2024
    Assignees: Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
  • Publication number: 20240119869
    Abstract: A pressure-sensitive label is provided. The pressure-sensitive label includes a support portion including a carrier layer and a transfer portion operatively connected to the support portion. The transfer portion includes at least an adhesive layer and an indicia layer. The transfer portion does not include a face stock layer. The transfer portion is configured for transfer of the transfer portion from the support portion to an article upon application of pressure to the transfer portion while the transfer portion is in contact with the article. A method of making a pressure-sensitive label is also provided. The method includes providing a first carrier layer, applying an indicia layer atop the first carrier layer, applying an adhesive layer atop the indicia layer, and applying a second carrier layer atop the adhesive layer.
    Type: Application
    Filed: October 11, 2023
    Publication date: April 11, 2024
    Inventors: Barron G. McKillip, Justin G. Long, Benjamin M. Wolfe, A. Craig Bushman
  • Patent number: 11946392
    Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: April 2, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Michael E. Slipper, Tristan M. Wolfe, Kyle J. Verrinder
  • Patent number: 11826678
    Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: November 28, 2023
    Assignee: Aqseptence Group, Inc.
    Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
  • Patent number: 11585227
    Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: February 21, 2023
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Michael E. Slipper, Tristan M. Wolfe, Kyle J. Verrinder
  • Publication number: 20210354057
    Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.
    Type: Application
    Filed: March 2, 2021
    Publication date: November 18, 2021
    Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
  • Publication number: 20210260206
    Abstract: Provided herein are oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: March 15, 2019
    Publication date: August 26, 2021
    Applicants: Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
    Inventors: Bradley L. PENTELUTE, Colin M. FADZEN, Rebecca L. HOLDEN, Justin M. WOLFE, Zi-Ning CHOO, Monica YAO, Gunnar J. HANSON
  • Patent number: 10933353
    Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: March 2, 2021
    Assignee: Aqseptence Group, Inc.
    Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
  • Publication number: 20200316210
    Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: October 17, 2018
    Publication date: October 8, 2020
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
  • Publication number: 20200237922
    Abstract: Provided herein are oligonucleotides, bicyclic peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: October 17, 2018
    Publication date: July 30, 2020
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
  • Patent number: 10109970
    Abstract: The disclosed invention is a slip ring assembly that provides electrical power transfer to centrifugal turbomachinery while minimizing or eliminating the presence of wires in the flow path. The device transfers electrical power through a set of wires connected to a plurality of brushes that are held rotationally stationary, but allowed to displace axially or radially through a set of springs. The brushes make contact with conductive busbar rings, transferring electricity to the busbar rings. The busbar rings rotate with the centrifugal turbomachine with a set of wires that connect the busbar rings to the blades or other aerodynamic surfaces of the centrifugal turbomachine.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: October 23, 2018
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Michael E. Slipper, Tristan M. Wolfe, Daniel J. Simmons
  • Patent number: 10033145
    Abstract: The disclosed invention is a slip ring assembly that provides electrical power transfer to centrifugal turbomachinery while minimizing or eliminating the presence of wires in the flow path. The device transfers electrical power through a set of wires connected to a plurality of brushes that are held rotationally stationary, but allowed to displace axially or radially through a set of springs. The brushes make contact with conductive busbar rings, transferring electricity to the busbar rings. The busbar rings rotate with the centrifugal turbomachine with a set of wires that connect the busbar rings to the blades or other aerodynamic surfaces of the centrifugal turbomachine.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: July 24, 2018
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Michael E. Slipper, Tristan M. Wolfe, Daniel J. Simmons
  • Publication number: 20180185980
    Abstract: The present disclosure relates to a dressing tool. The dressing tool can include a shank having a proximal end and a distal end as well as an abrasive tip. The abrasive tip may include a superabrasive material that may be bonded to the distal end of the shank. The abrasive tip may be tilted relative to a longitudinal axis of the shank.
    Type: Application
    Filed: December 29, 2017
    Publication date: July 5, 2018
    Inventors: Kevin M. WOLFE, Elizabeth SKOMRA, Juan ARAIZA, IV
  • Patent number: 9960715
    Abstract: Provided is a light activated piezoelectric converter comprising a cantilever vane coupled to a foundation. The vane comprises a first surface and a second surface. The first and second surfaces are generally co-planer and adjacent to a common boundary and have differing emissivities. A piezoelectric material is additionally coupled to the vane, arranged such that a deflection of the free end of the vane generates stress acting on the piezoelectric material. When the piezoelectric converter is illuminated with a radiant flux, the differing emissivities of the first and second surfaces produce a temperature gradient across the vane and a thermal creep force across the planar surface generates a deflection of the vane, and a subsequent voltage induced by the stress on the piezoelectric material generates a voltage between a first electrode and second electrode in electrical contact with the piezoelectric material.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: May 1, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Andres Larraza, David M. Wolfe
  • Patent number: 9943201
    Abstract: A movable fluid collection device includes a mat assembly, a first conduit segment, and a second conduit segment. The mat assembly includes an absorption material and a low-friction sliding floor-contact material. The first conduit segment may include a loop of tubing having at least one fluid collection opening formed therein, and the second conduit segment connects the first conduit to a suction collection system.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: April 17, 2018
    Assignee: BIG FOOT SUCTION, LLC
    Inventors: Nicholas A. Esposito, Carol M. Wolfe, Justin Pagano, Keith Bright
  • Patent number: 9894069
    Abstract: Secret application and maintenance policy data is generated for different classes of data. The class of data to be protected is determined and the secret application and maintenance policy data for the determined class of the data to be protected is identified and obtained. Required secrets data representing one or more secrets to be applied to the data to be protected is obtained and then automatically scheduled for application to the data to be protected in accordance with the secret application and maintenance policy data for the determined class of the data to be protected. Maintenance of the one or more secrets is also automatically scheduled in accordance with the secret application and maintenance policy data for the determined class of the data to be protected.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: February 13, 2018
    Assignee: Intuit Inc.
    Inventors: Brett Weaver, Sabu Kuruvila Philip, Troy Otillio, Jinglei Whitehouse, III, Oleg Gryb, Jeffrey M. Wolfe, Ankur Jain, M. Shannon Lietz, Luis Felipe Cabrera
  • Publication number: 20180007048
    Abstract: Secret application and maintenance policy data is generated for different classes of data. The class of data to be protected is determined and the secret application and maintenance policy data for the determined class of the data to be protected is identified and obtained. Required secrets data representing one or more secrets to be applied to the data to be protected is obtained and then automatically scheduled for application to the data to be protected in accordance with the secret application and maintenance policy data for the determined class of the data to be protected. Maintenance of the one or more secrets is also automatically scheduled in accordance with the secret application and maintenance policy data for the determined class of the data to be protected.
    Type: Application
    Filed: November 1, 2013
    Publication date: January 4, 2018
    Applicant: Intuit Inc.
    Inventors: Brett Weaver, Sabu Kuruvila Philip, Troy Otillio, Jinglei Whitehouse, Oleg Gryb, Jeffrey M. Wolfe, Ankur Jain, M. Shannon Lietz, Luis Felipe Cabrera
  • Patent number: 9822786
    Abstract: Provided is a light activated rotor comprising typically a plurality of vanes affixed to a hub rotatable around the longitudinal axis of an axle. Each vane comprises a planar surface oriented generally perpendicular to the longitudinal axis of the axle with each vane separated into a first surface and a second surface. The first and second surface are adjacent and share a common boundary generally perpendicular to the longitudinal axis of the axle. Additionally, the first and second surfaces have differing emissivities. When the light activated rotor is illuminated with a radiant flux, the differing emissivities of the first and second surfaces produce a temperature gradient across the vane and generally perpendicular to the longitudinal axis, and a thermal creep force across the planar surface of the vane generates a revolution of the vane and the affixed hub around the longitudinal axis of the axle.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: November 21, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Andres Larraza, David M. Wolfe
  • Patent number: 9811017
    Abstract: A low melt toner includes a core having a core polystyrene-butyl acrylate resin, a crystalline polyester resin, a pigment present in an amount from about 7% to about 20% by weight of the low melt toner, and a paraffin wax; a ratio of the polystyrene-butyl acrylate resin to crystalline polyester resin is in a range from about 5:1 to about 7:1; and a shell disposed over the core including a shell polystyrene-butyl acrylate resin.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 7, 2017
    Assignee: XEROX CORPORATION
    Inventors: Christopher M. Wolfe, Padam K. Angra, Jacob W. Myers, II