Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

Abstract: This document provides methods and materials for detecting misfolded poly peptides. For example, devices (e.g., feeding devices) designed to collect samples from one or more mammals (e.g., one or more cervids) are provided. In some cases, methods and materials that can be used to detect one or more prion diseases (e.g., chronic wasting disease (CWD)) in a population of mammals (e.g., a herd of cervids) based, at least in part, on the presence or absence of misfolded polypeptides in a sample from one or more mammals that was obtained from a feeding device are provided.

Abstract: A flight school credentialing and verification system uses software tools to implement flight school functionality, including scheduling flight course sessions, customizing flight course sessions, and integrating third party tools, all in accordance with safety requirements as established by a regulatory body. For example, a flight school credentialing and verification software application may determine whether credential items of a user satisfy credential definitions defined for a flight course. Responsive to a determination that the credential items satisfy the credential definitions, an availability of one or more resources of a flight school used for the flight course can be verified, and, responsive to that verification, one or more candidate flight course registrations are determined. A flight course output indicative of a selected flight course registration is then generated.

Abstract: Systems and methods for identity-based interconnected transactions are disclosed. The system may receive an interconnected transaction request comprising a first financial subsystem identifier, a second financial subsystem identifier, and a transaction request. The first financial subsystem and the second financial subsystem may not be in direct communication with each other. The first financial subsystem may write the interconnected transaction request to an interconnected transaction ledger. The second financial subsystem may retrieve the interconnected transaction request from the interconnected transaction ledger. In response to retrieving the interconnected transaction request the second financial subsystem may complete the transaction request.

Abstract: A pressure-sensitive label is provided. The pressure-sensitive label includes a support portion including a carrier layer and a transfer portion operatively connected to the support portion. The transfer portion includes at least an adhesive layer and an indicia layer. The transfer portion does not include a face stock layer. The transfer portion is configured for transfer of the transfer portion from the support portion to an article upon application of pressure to the transfer portion while the transfer portion is in contact with the article. A method of making a pressure-sensitive label is also provided. The method includes providing a first carrier layer, applying an indicia layer atop the first carrier layer, applying an adhesive layer atop the indicia layer, and applying a second carrier layer atop the adhesive layer.

Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.

Abstract: Provided herein is technology relating to functional microbial consortia and particularly, but not exclusively, to methods and systems for producing a microbial consortium possessing a desired function and microbial consortia produced according to such methods. The microbial consortia may be used to improve soil, e.g., for agricultural uses.

Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.

Abstract: The present invention relates to a self-contained growth system that functions as a stand-alone growth system or combined with a hydroponic or aeroponic growth system for the controlled growth of plants. A Spiral Tower having an entry port for seedling or seeds embedded onto trays floating on a downward spiraling water flow provides a closed environment with optimum nutrient and growth conditions for each plant type. The Spiral Tower is capable of germinating seedlings in a closed environment for subsequent maturation in an aeroponic or other system. As a stand-alone growth system, the Spiral Tower is capable of the continued growth of certain early life plants. Other applications as a seed to harvest system used in harvesting wheatgrass and similar plants. The system is designed for cost-effective use in restricted space and in regions not conducive for commercial plant production.

Abstract: A core training apparatus for the golf swing. A semicircular member is coupled with a support member, and a resistance member is connected to one of the coupling points. The resistance member is secured to a fixed point, and the user rotates the apparatus back and forth with the user standing at the center rotational axis of the semicircular member, with the resistance member being guided along the semicircular member. The back-and-forth rotation acts to increase and decrease tension on the resistance member thereby exercising the core of the user.

Abstract: A core training apparatus for the golf swing. A semicircular member is coupled with a support member, and a resistance member is connected to one of the coupling points. The resistance member is secured to a fixed point, and the user rotates the apparatus back and forth with the user standing at the center rotational axis of the semicircular member, with the resistance member being guided along the semicircular member. The back-and-forth rotation acts to increase and decrease tension on the resistance member thereby exercising the core of the user.

Abstract: An electronic trading system utilizes a Match Engine that receives orders, stores them internally, calculates tradable combinations and advertises the availability of real and implied orders in the form of market data. New tradable items defined as combinations of other tradable items may be included in the calculation of tradable combinations. A technique is disclosed for suppression of the calculation and/or subsequent listing of an implied order when the order is either undesired or unnecessary in the market therefore.

Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.

Abstract: An electronic trading system utilizes a Match Engine that receives orders, stores them internally, calculates tradable combinations and advertises the availability of real and implied orders in the form of market data. New tradable items defined as combinations of other tradable items may be included in the calculation of tradable combinations. A technique is disclosed for suppression of the calculation and/or subsequent listing of an implied order when the order is either undesired or unnecessary in the market therefore.

Abstract: An antenna assembly has a main body configured to receive an antenna, and an uninterrupted top cap attached to the main body. The uninterrupted top cap has an outer surface. A lifting assembly is attached to at the outer surface of said top cap without penetrating the cap. Accordingly, the uninterrupted cap forms an unbroken whole. The uninterrupted cap is continuous without any through-holes or other perturbances or features that extend through the cap or otherwise might allow fluid to pass through the cap into an interior of the main body.

Abstract: Provided herein is technology relating to identifying and isolating microorganisms having a targeted function and particularly, but not exclusively, to methods, compositions, and systems for screening and/or selecting individual microorganisms or microbial consortia that provide specified functions.

Abstract: A flight school credentialing and verification system uses software tools to implement flight school functionality, including scheduling flight course sessions, customizing flight course sessions, and integrating third party tools, all in accordance with safety requirements as established by a regulatory body. For example, a flight school credentialing and verification software application may determine whether credential items of a user satisfy credential definitions defined for a flight course. Responsive to a determination that the credential items satisfy the credential definitions, an availability of one or more resources of a flight school used for the flight course can be verified, and, responsive to that verification, one or more candidate flight course registrations are determined. A flight course output indicative of a selected flight course registration is then generated.

Abstract: The present invention relates to a self-contained growth system that functions as a stand-alone growth system or combined with a hydroponic or aeroponic growth system for the controlled growth of plants. A Spiral Tower having an entry port for seedling or seeds embedded onto trays floating on a downward spiraling water flow provides a closed environment with optimum nutrient and growth conditions for each plant type. The Spiral Tower is capable of germinating seedlings in a closed environment for subsequent maturation in an aeroponic or other system. As a stand-alone growth system, the Spiral Tower is capable of the continued growth of certain early life plants. Other applications as a seed to harvest system used in harvesting wheatgrass and similar plants. The system is designed for cost-effective use in restricted space and in regions not conducive for commercial plant production.

Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.

Abstract: Devices (dot blot boxes) for use in immunoblotting are described. The dot blot boxes can include a series of hooks, clips or the like on opposite sides of a container for retaining a test strip there between. The dot blot boxes can be sized to retain a plurality of test strips generally parallel to one another such that they do not contact one another and do not contact the base of the container. A container can hold a fluid, e.g., a blocking buffer solution or antibody solution, and the test strips can be submerged in the fluid while retained in the container.