Patents by Inventor M. Wolfe
M. Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250135015Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.Type: ApplicationFiled: August 9, 2024Publication date: May 1, 2025Applicants: Sarepta Therapeutics, Inc., Massachusetts Institute of TechnologyInventors: Justin M. WOLFE, Colin M. FADZEN, Zi-Ning CHOO, Rebecca L. HOLDEN, Monica YAO, Gunnar J. HANSON, Bradley L. PENTELUTE
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Patent number: 12138312Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.Type: GrantFiled: October 17, 2018Date of Patent: November 12, 2024Assignees: Sarepta Therapeutics, Inc., Massachusetts Institute of TechnologyInventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
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Publication number: 20240119869Abstract: A pressure-sensitive label is provided. The pressure-sensitive label includes a support portion including a carrier layer and a transfer portion operatively connected to the support portion. The transfer portion includes at least an adhesive layer and an indicia layer. The transfer portion does not include a face stock layer. The transfer portion is configured for transfer of the transfer portion from the support portion to an article upon application of pressure to the transfer portion while the transfer portion is in contact with the article. A method of making a pressure-sensitive label is also provided. The method includes providing a first carrier layer, applying an indicia layer atop the first carrier layer, applying an adhesive layer atop the indicia layer, and applying a second carrier layer atop the adhesive layer.Type: ApplicationFiled: October 11, 2023Publication date: April 11, 2024Inventors: Barron G. McKillip, Justin G. Long, Benjamin M. Wolfe, A. Craig Bushman
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Patent number: 11946392Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.Type: GrantFiled: January 18, 2023Date of Patent: April 2, 2024Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Michael E. Slipper, Tristan M. Wolfe, Kyle J. Verrinder
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Patent number: 11826678Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.Type: GrantFiled: March 2, 2021Date of Patent: November 28, 2023Assignee: Aqseptence Group, Inc.Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
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Patent number: 11585227Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.Type: GrantFiled: October 31, 2019Date of Patent: February 21, 2023Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Michael E. Slipper, Tristan M. Wolfe, Kyle J. Verrinder
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Publication number: 20210354057Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.Type: ApplicationFiled: March 2, 2021Publication date: November 18, 2021Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
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Publication number: 20210260206Abstract: Provided herein are oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates described herein.Type: ApplicationFiled: March 15, 2019Publication date: August 26, 2021Applicants: Sarepta Therapeutics, Inc., Massachusetts Institute of TechnologyInventors: Bradley L. PENTELUTE, Colin M. FADZEN, Rebecca L. HOLDEN, Justin M. WOLFE, Zi-Ning CHOO, Monica YAO, Gunnar J. HANSON
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Patent number: 10933353Abstract: A support grid assembly for use in a vessel. The support grid assembly includes panels each including a first wall including a media-supporting screen and a second wall to be supported by the vessel wall inner surface. A manifold is coupled to the panels and is in hydraulic communication with vessel outlet. The manifold and the panels permit fluid to flow through the screen in each panel, through the panels, into the manifold, and through the manifold to the outlet of the vessel, as well as in the reverse direction. At least a portion of the first wall may slope downward toward the manifold, and at least a portion of the second wall may form a bottom surface that is curved to substantially conform to a curvature of the vessel wall inner surface. The panels may be arranged in a circular configuration extending radially from the manifold.Type: GrantFiled: July 26, 2013Date of Patent: March 2, 2021Assignee: Aqseptence Group, Inc.Inventors: Garth Hayes Saul, Robert Glen Norell, Dean Gerald Brabec, Benjamin Schmitt, Dusan Visekruna, Michael Richard Ekholm, Eugene Eberhardt, Edmund M. Wolfe
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Publication number: 20200316210Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.Type: ApplicationFiled: October 17, 2018Publication date: October 8, 2020Inventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
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Publication number: 20200237922Abstract: Provided herein are oligonucleotides, bicyclic peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.Type: ApplicationFiled: October 17, 2018Publication date: July 30, 2020Inventors: Justin M. Wolfe, Colin M. Fadzen, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
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Patent number: 10109970Abstract: The disclosed invention is a slip ring assembly that provides electrical power transfer to centrifugal turbomachinery while minimizing or eliminating the presence of wires in the flow path. The device transfers electrical power through a set of wires connected to a plurality of brushes that are held rotationally stationary, but allowed to displace axially or radially through a set of springs. The brushes make contact with conductive busbar rings, transferring electricity to the busbar rings. The busbar rings rotate with the centrifugal turbomachine with a set of wires that connect the busbar rings to the blades or other aerodynamic surfaces of the centrifugal turbomachine.Type: GrantFiled: May 23, 2017Date of Patent: October 23, 2018Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael E. Slipper, Tristan M. Wolfe, Daniel J. Simmons
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Patent number: 10033145Abstract: The disclosed invention is a slip ring assembly that provides electrical power transfer to centrifugal turbomachinery while minimizing or eliminating the presence of wires in the flow path. The device transfers electrical power through a set of wires connected to a plurality of brushes that are held rotationally stationary, but allowed to displace axially or radially through a set of springs. The brushes make contact with conductive busbar rings, transferring electricity to the busbar rings. The busbar rings rotate with the centrifugal turbomachine with a set of wires that connect the busbar rings to the blades or other aerodynamic surfaces of the centrifugal turbomachine.Type: GrantFiled: May 23, 2017Date of Patent: July 24, 2018Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael E. Slipper, Tristan M. Wolfe, Daniel J. Simmons
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Publication number: 20180185980Abstract: The present disclosure relates to a dressing tool. The dressing tool can include a shank having a proximal end and a distal end as well as an abrasive tip. The abrasive tip may include a superabrasive material that may be bonded to the distal end of the shank. The abrasive tip may be tilted relative to a longitudinal axis of the shank.Type: ApplicationFiled: December 29, 2017Publication date: July 5, 2018Inventors: Kevin M. WOLFE, Elizabeth SKOMRA, Juan ARAIZA, IV
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Patent number: 9960715Abstract: Provided is a light activated piezoelectric converter comprising a cantilever vane coupled to a foundation. The vane comprises a first surface and a second surface. The first and second surfaces are generally co-planer and adjacent to a common boundary and have differing emissivities. A piezoelectric material is additionally coupled to the vane, arranged such that a deflection of the free end of the vane generates stress acting on the piezoelectric material. When the piezoelectric converter is illuminated with a radiant flux, the differing emissivities of the first and second surfaces produce a temperature gradient across the vane and a thermal creep force across the planar surface generates a deflection of the vane, and a subsequent voltage induced by the stress on the piezoelectric material generates a voltage between a first electrode and second electrode in electrical contact with the piezoelectric material.Type: GrantFiled: May 5, 2016Date of Patent: May 1, 2018Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Andres Larraza, David M. Wolfe
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Patent number: 9943201Abstract: A movable fluid collection device includes a mat assembly, a first conduit segment, and a second conduit segment. The mat assembly includes an absorption material and a low-friction sliding floor-contact material. The first conduit segment may include a loop of tubing having at least one fluid collection opening formed therein, and the second conduit segment connects the first conduit to a suction collection system.Type: GrantFiled: May 22, 2015Date of Patent: April 17, 2018Assignee: BIG FOOT SUCTION, LLCInventors: Nicholas A. Esposito, Carol M. Wolfe, Justin Pagano, Keith Bright
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Patent number: 9894069Abstract: Secret application and maintenance policy data is generated for different classes of data. The class of data to be protected is determined and the secret application and maintenance policy data for the determined class of the data to be protected is identified and obtained. Required secrets data representing one or more secrets to be applied to the data to be protected is obtained and then automatically scheduled for application to the data to be protected in accordance with the secret application and maintenance policy data for the determined class of the data to be protected. Maintenance of the one or more secrets is also automatically scheduled in accordance with the secret application and maintenance policy data for the determined class of the data to be protected.Type: GrantFiled: November 1, 2013Date of Patent: February 13, 2018Assignee: Intuit Inc.Inventors: Brett Weaver, Sabu Kuruvila Philip, Troy Otillio, Jinglei Whitehouse, III, Oleg Gryb, Jeffrey M. Wolfe, Ankur Jain, M. Shannon Lietz, Luis Felipe Cabrera
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Publication number: 20180007048Abstract: Secret application and maintenance policy data is generated for different classes of data. The class of data to be protected is determined and the secret application and maintenance policy data for the determined class of the data to be protected is identified and obtained. Required secrets data representing one or more secrets to be applied to the data to be protected is obtained and then automatically scheduled for application to the data to be protected in accordance with the secret application and maintenance policy data for the determined class of the data to be protected. Maintenance of the one or more secrets is also automatically scheduled in accordance with the secret application and maintenance policy data for the determined class of the data to be protected.Type: ApplicationFiled: November 1, 2013Publication date: January 4, 2018Applicant: Intuit Inc.Inventors: Brett Weaver, Sabu Kuruvila Philip, Troy Otillio, Jinglei Whitehouse, Oleg Gryb, Jeffrey M. Wolfe, Ankur Jain, M. Shannon Lietz, Luis Felipe Cabrera
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Patent number: 9822786Abstract: Provided is a light activated rotor comprising typically a plurality of vanes affixed to a hub rotatable around the longitudinal axis of an axle. Each vane comprises a planar surface oriented generally perpendicular to the longitudinal axis of the axle with each vane separated into a first surface and a second surface. The first and second surface are adjacent and share a common boundary generally perpendicular to the longitudinal axis of the axle. Additionally, the first and second surfaces have differing emissivities. When the light activated rotor is illuminated with a radiant flux, the differing emissivities of the first and second surfaces produce a temperature gradient across the vane and generally perpendicular to the longitudinal axis, and a thermal creep force across the planar surface of the vane generates a revolution of the vane and the affixed hub around the longitudinal axis of the axle.Type: GrantFiled: April 7, 2016Date of Patent: November 21, 2017Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Andres Larraza, David M. Wolfe
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Patent number: 9811017Abstract: A low melt toner includes a core having a core polystyrene-butyl acrylate resin, a crystalline polyester resin, a pigment present in an amount from about 7% to about 20% by weight of the low melt toner, and a paraffin wax; a ratio of the polystyrene-butyl acrylate resin to crystalline polyester resin is in a range from about 5:1 to about 7:1; and a shell disposed over the core including a shell polystyrene-butyl acrylate resin.Type: GrantFiled: February 26, 2016Date of Patent: November 7, 2017Assignee: XEROX CORPORATIONInventors: Christopher M. Wolfe, Padam K. Angra, Jacob W. Myers, II