Patents by Inventor Mahalakshmi Yerramilli

Mahalakshmi Yerramilli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10436797
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 8, 2019
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Publication number: 20180335423
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 22, 2018
    Inventors: Murthy V.S.N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Patent number: 9970927
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: May 15, 2018
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Murthy V. S. N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Publication number: 20180120326
    Abstract: Methods for determining renal function in an animal subject, the method including measuring the concentration of ?-ammoisobutyric acid (?-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.
    Type: Application
    Filed: May 2, 2016
    Publication date: May 3, 2018
    Inventors: Mahalakshmi Yerramilli, Edward Obare, John Joseph Quinn, Murthy VSN Yerramilli
  • Publication number: 20170269101
    Abstract: The disclosure provides compositions and methods for the detection of renal disease and periodontal disease in mammals.
    Type: Application
    Filed: March 2, 2017
    Publication date: September 21, 2017
    Inventors: Mahalakshmi Yerramilli, Giosi Farace, John J. Quinn, Murthy V.S.N. Yerramilli
  • Publication number: 20160187348
    Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.
    Type: Application
    Filed: March 4, 2016
    Publication date: June 30, 2016
    Inventors: Mahalakshmi Yerramilli, Murthy VSN Yerramilli
  • Patent number: 9091684
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: July 28, 2015
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Murthy V. S. N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Publication number: 20140295464
    Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 2, 2014
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V.S.N. Yerramilli
  • Publication number: 20140242723
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Application
    Filed: February 28, 2014
    Publication date: August 28, 2014
    Applicant: IDEXX Laboratories, Inc.
    Inventors: Murthy V.S.N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Patent number: 8778699
    Abstract: A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits and device.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: July 15, 2014
    Assignee: Idexx Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V. S. N. Yerramilli
  • Publication number: 20130280740
    Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 24, 2013
    Inventors: Murthy V.S.N. Yerramilli, Mahalakshmi Yerramilli, Michael Atkinson, Kwok Kam Yeung
  • Publication number: 20130274453
    Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 17, 2013
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V.S.N. Yerramilli
  • Patent number: 8481333
    Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: July 9, 2013
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V. S. N. Yerramilli
  • Publication number: 20130130285
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 23, 2013
    Applicant: IDEXX LABORATORIES, INC.
    Inventors: Michael Randolph Atkinson, Mahalakshmi Yerramilli, Murthy V.S.N. Yerramilli
  • Publication number: 20120329175
    Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
    Type: Application
    Filed: May 31, 2012
    Publication date: December 27, 2012
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V.S.N. Yerramilli
  • Publication number: 20120034710
    Abstract: A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits and device.
    Type: Application
    Filed: August 4, 2011
    Publication date: February 9, 2012
    Applicant: IDEXX LABORATORIES, INC.
    Inventors: Mahalakshmi Yerramilli, Michael Atkinson, Murthy V.S.N. Yerramilli