Abstract: The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX, formula X, formula XI, formula XII, formula XIII, formula XIV and formula XV and the methods for the treatment of chronic pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of chronic pain.

Abstract: An XYZ flexural mechanism comprising an X-axis flexural mechanism comprising a first voice coil actuator, a motion stage platform, a plurality of flexural bearings, and a plurality of guide rods, a Y-axis flexural mechanism comprising a second voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, and a Z-axis flexural mechanism comprising a third voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, the frame supporting the XYZ flexural mechanism.

Abstract: Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized between the sample application zone and the conjugate zone. In embodiments with a sample compressor, one or more mucolytic agents may be pre-loaded and dried on the sample compressor, the sample collector, in various locations on the test strip, or in the running buffer.

Abstract: A measuring element for a water meter assembly is provided. The measuring element may be interchangeably installed within a main case that is permanently situated in-line with a monitored piping system. The measuring element includes a measuring channel, an electronics module, and an acoustic reflector plate. The measuring element has a top wall with multiple ports and a bottom wall with a recess. The electronics module is mounted above the top wall. The electronics module includes one or more pairs of ultrasonic transducers configured to transmit ultrasonic signals through the multiple ports into the measuring channel, and a processor to calculate a flow value based on the transmitted ultrasonic signals from the one or more pairs of ultrasonic transducers. The acoustic reflector plate is mounted in the recess and includes at least one concave reflector that reflects the transmitted ultrasonic signals between the one or more pairs of ultrasonic transducers.

Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.

Abstract: A tire sealant composition for use in tubeless tires is disclosed. The tire sealant composition primarily serves to seal the tire around the wheel rim and particularly in the tread area of the tire against punctures. The composition includes polymeric material, carrier fluid and particulate system. The tire sealant composition is flowable, non-toxic, non-corrosive and thermally stable.

Abstract: A method performed by a computing system that collects information on transactions in a telecommunication system includes receiving an event object. The event object includes parameters associated with a telecommunication event. The method further includes classifying the event object, using a classification mechanism, as one of a plurality of Key Performance Indicators (KPIs) by using the parameters, including considering events from multiple protocols for classifying event objects. The method further includes, after classifying the event object, inferring relationships between a set of inputs and a set of outputs, the set of inputs including information types from the event object and the set of outputs including KPIs.

Abstract: In some aspects, the present disclosure provides methods of aminating an aromatic compound comprising reacting an aminating agent with an aromatic compound in the presence of a rhodium catalyst. In some embodiments, the methods may comprise aminating an aromatic compound which contains multiple different functional groups. The methods described herein may also be used to create bicyclic system comprising reacting an intramolecular aminating agent with an aromatic ring to obtain a second ring containing a nitrogen atom. In another aspect, the methods described herein may also be used to create a cyclic aliphatic cyclic/poly cyclic amine system comprising a reacting an intramolecular aminating agent by insertion into a C(sp3)-H bond.

Abstract: A networked device communication system can configure network devices (e.g., a primary and secondary database) to send and receive sequences of messages, such as replicated data, using one or more keypairs and wrapping keys. The sequences of messages can include an initial set of messages that are encrypted by a wrapping key, and further include another set of messages that are encrypted by a replaced staggered key. The sequence of messages can be configured to be decrypted without exporting keys of hardware security modules.

Abstract: Methods, systems, and techniques for facilitating improved training of a supervised machine learning process, such as a decision tree. First and second object detections of an object depicted in a video are respectively generated using first and second object detectors, with the second object detector requiring more computational resources than the first object detector to detect the object. Whether a similarity and a difference between the first and second object detections respectively satisfy a similarity threshold and a difference threshold is determined. When the similarity threshold is satisfied, the first object detection is stored as a positive example for the machine learning training. When the difference threshold is satisfied, the first object detection is stored as a negative example for the machine learning training.

Abstract: A method of implementing sub-table replication starts with the processor detecting a first update to an entitlements table. The processor filters of a data table based on the first update. The processor then detects a second update to the entitlements table and performs incremental replication of the data table by causing a full inventory replication at a next refresh to be executed for provider accounts associated with the provider account identifiers in the entitlements table. Other embodiments are also described herein.

Abstract: A method for performing a backup operation includes obtaining a restoration request, and in response to the restoration request: identifying a first set of backups, wherein each backup in the first set of backups is associated with requested data, mounting the first set of backups from the backup storage system, performing data mining on the first set of backups to obtain a hierarchical structure, providing a set of options to a client based on the hierarchical structure, obtaining a selection from the client, wherein the selection is a portion of the set of options, obtaining selected content based on the selection, wherein the selected content is in a source format, converting the selected content from a source format to a target format to obtain target formatted user-specified content, and initiating a transfer of the target-formatted user-specified content to a cloud-based service.

Abstract: A method for performing a backup operation includes obtaining, by a backup server, a backup request, wherein the backup request specifies a virtual machine to be backed up, wherein the virtual machine is hosted by a production host, and in response to the backup request: obtaining classification data from the backup agent, initiating a backup classification on an unprocessed backup associated with the virtual machine based on the classification data to obtain a sensitivity tag, and initiating a data processing on the unprocessed backup based on the sensitivity tag.

Abstract: A method for producing a streak-suppressed magnetic resonance (MR) image of a subject includes generating an interference covariance matrix {circumflex over (?)}R front N coil images Ij (x,y), j={1, 2, . . . , N}, each of the N coil images Ij (x,y) corresponding to MR signals detected by a respective one of a phased array of N coils of an MRI scanner. The MR signals originate in voxels of the subject corresponding to an artifact-corrupted region of a coil image. Coordinates (x,y) correspond to a location within a cross-sectional plane of the subject. The method also includes, for subject-regions of cross-sectional plane centered at a respective location (x,y), determining a coil weight vector W (x,y) from {circumflex over (?)}R. The method also includes generating the streak-suppressed MR image as a weighted sum of the coil images Ij (x,y), each weight of the weighted sum being Wj* (x,y), a jth element of a complex conjugate of coil weight vector W (x,y).

Abstract: Methods, systems, and computer-readable storage media for automatic creation of distributed ledger networks. A request to deploy a distributed ledger network is received by an automation framework. The request comprising a configuration file and is associated with a platform type for one or more platforms for deployment of the distributed ledger network. Configuration prerequisites are determined for performing installations of software components on the one or more platforms. In response to installing the software components, the software components are configured and executed to set up an environment for deploying the distributed ledger network by creating a build folder, copying the configuration file and key files for accessing a source code repository into the build folder, and updating the configuration file according to criteria associated with the platform type.

Abstract: A device identifies training data and scoring data for a model, and removes bias from the training data to generate unbiased training data. The device trains the model with the unbiased training data to generate trained models, and processes the trained models, with the scoring data, to generate scores for the trained models. The device selects a trained model, from the trained models, based on model metrics and the scores, and processes a training sample, with the trained model, to generate first results, wherein the training sample is created based on the unbiased training data and production data. The device processes a production sample, with the trained model, to generate second results, wherein the production sample is created based on the production data and the training sample. The device provides the trained model for use in a production environment based on the first results and the second results.

Abstract: Methods and systems of identifying a time reduction in a manufacturing time associated with a plurality of products. One system includes an electronic processor configured to receive a dataset associated with an assembly line. The dataset includes a classification for each of the plurality of products produced by the assembly line, where the assembly line is associated with a plurality of tests. The electronic processor is also configured to determine a set of test combinations for the assembly line based on the plurality of tests and, for each test combination, determine a number of missing products based on the classification for each of the plurality of products. The electronic processor is also configured to determine at least one test to remove based on the number of missing products for each test combination and output a result including an indication of the at least one test to remove.

Abstract: A system and method for reliable control of a high rotor pole switched reluctance machine (HRSRM) utilizing a sensorless reliable control system. The method comprising: energizing at least one of the plurality of stator phases; measuring a first current value and time taken by the first current value to reach a first peak value or preset threshold value of current; determining a self-inductance value; measuring a second current value and time taken by an adjacent un-energized stator phase to reach a second peak value of current; determining a mutual inductance value; and estimating a rotor position utilizing the self-inductance and mutual inductance values; and controlling the HRSRM based on the estimated rotor position.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a touchless testing platform employed to, for example, create automated testing scripts, sequence test cases, and implement determine defect solutions.

Abstract: The present disclosure may be directed to defoaming methods and compositions. A method of treating a subterranean formation may comprise providing a defoaming composition, wherein the defoaming composition comprises a tall-oil-derived surfactant. The method may further comprise mixing the defoaming composition with an aqueous fluid to form a treatment fluid such that foaming in the treatment fluid is reduced, wherein the treatment fluid is a water-based fluid. The method may further comprise placing the treatment fluid into the subterranean formation.