Abstract: The application discloses a method for obtaining MSC-derived cells with improved transplantation properties from MSC, the method comprising a cell size reduction step, wherein said cell size reduction step is characterized by contacting MSC or MSC-derived cells in vitro or ex vivo with heparin or a derivative or analogue thereof at a concentration of at least 0.01 IU/ml. The application further provides a method for obtaining mesenchymal stem cell-derived cells from mesenchymal stem cells (MSC) comprising contacting MSC in vitro or ex vivo with FGF-2, TGF? and at least 0.01 IU/ml heparin or a derivative or analogue thereof. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof.

Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent. In certain embodiments, the method includes determining, by immunohistochemistry, the number of PD-L1 positive malignant cells in a tumor tissue section as well as the number of infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area. The infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area are positive for a marker selected from PD-L1, CD8, CD68, and any combination thereof. Compositions and kits or performing the disclosed methods are also provided.

Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.

Abstract: A cover device selectively covers a camera of an electronic device. The cover device includes a housing and a camera cover device to selectively cover or uncover the camera. The housing has an opening to receive the electronic device. The camera cover device is positioned on a front wall of the housing, and is configured to be selectively moveable to a closed position in which the camera of the electronic device is covered and an open position in which the camera of the electronic device is not covered when the electronic device is inserted into the opening, the camera cover device including a removeable portion. The removeable portion has a design element visible to a user when the removeable portion is disposed on the camera cover device. A user of the camera cover device can utilize removeable portions with different design elements to present a different look.

Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.

Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.

Abstract: System and methods for manipulating rights expressions for use in connection with a rights management system include one or more tokenized templates. Each tokenized template includes one or more rights expression language statements and one or more tokens associated with at least one of the rights expression language statements. Further, the tokens can be place holders for data items or rights expression elements. The system further includes a license template module that creates the tokenized templates, and a license instance creation module that replaces at least one of the tokens in one or more selected license templates with one or more of the data items or rights expression elements to generate a license instance. Additionally, the system includes a license instance analysis module having sub-modules for validating and interpreting license instances, and a data parsing module for extracting data from created license instances.

Abstract: Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent. In certain embodiments, the method includes determining, by immunohistochemistry, the number of PD-L1 positive malignant cells in a tumor tissue section as well as the number of infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area. The infiltrating non-malignant cells and/or non-malignant cells of the stromal interface area are positive for a marker selected from PD-L1, CD8, CD68, and any combination thereof. Compositions and kits or performing the disclosed methods are also provided.

Abstract: Methods and system for producing combined photoacoustic/ultrasonic image frames use a low-power narrow beam laser to direct sequential pulses along a path overlying an internal region of interest. Photoacoustic responses are received and used to generate sub-frames. Between each of the laser pulses a plurality of ultrasound pulse-echo beams are sequentially emitted towards the region of interest, and the reflections are received and used to generate ultrasound sub-frames. The photoacoustic sub-frames are combined to produce a photoacoustic frame, and the ultrasound sub-frames are combined to produce an ultrasound frame. The photoacoustic and ultrasound frames are combined to produce an image frame. The method and system are suitable for producing real-time, high-contrast video.

Abstract: Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.

Abstract: An example fluidic device may include a plurality of channels including one or more curved channels having a channel input and a channel output. Each of the one or more curved channels may have a substantially circular cross-section. The fluidic device may also include an input interface between the channel input of the one or more curved channels and an exterior of the fluidic device. The input interface may be configured to receive a biological tissue sample. The fluidic device may also include an output interface between the channel output of the one or more curved channels and the exterior of the fluidic device.

Abstract: The present disclosure provides systems, methods, and devices for improved generation and application of radiation force to a material. In one aspect, a system for producing an acoustic radiation force to generate displacement in a material comprises an ultrasonic transducer array, one or more processors, and memory. The memory can comprise instructions that, when executed by the one or more processors, cause the system to generate a push acoustic energy focused to a push focal region in the material using the ultrasonic transducer array, so as to produce the acoustic radiation force to generate displacement in the material. The push focal region can comprise a first width along a first direction transverse to a direction of propagation of the push acoustic energy greater than a second width along a second direction transverse to the direction of propagation of the push acoustic energy.

Abstract: The invention relates to method for deriving a sub-right from a right, the right comprising a plurality of components, each of which specifies an aspect of the right. A component may be, for example, a principal, an action, a resource, and a condition. The invention also relates to a method for integrating a first right with a second right. Furthermore, the invention relates to a method of sharing rights by deriving a sub-right from a right, allowing use of the sub-right, and integrating the sub-right with the right.

Abstract: A system, method and computer program product for a digital content player having a DRM agent to perform rights management operations on a digital content package, including loading rights management instructions to be executed by the digital content player, the rights management instructions being associated with the digital content package, executing the rights management instructions on the digital content player, and loading supporting licenses associated with the digital content package for processing by the DRM agent. The DRM agent deciding whether to permit the rights management operations requested by the rights management instructions. Further exemplary embodiments include systems, methods and computer program products for associating usage rights with digital content packages, managing of digital rights tokens, managing of digital content packages having predetermined broadcast dates, preserving of usage rights when content is transferred between DRM environments, and distributing content packages.

Abstract: The present invention relates to uses of growth and differentiation factor 8 (GDF-8) in vitro or in vivo for reducing the immunogenicity or risk of rejection of cells such as in particular mesenchymal stem cells (MSC), tissues or materials. The present invention further relates to methods for differentiating MSC in vitro or ex vivo into osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells using FGF-2 and GDF-8. In addition, the present invention relates to osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells obtainable by such methods and to the osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells for use in the treatment of musculoskeletal diseases.

Abstract: A non-transient computer usable medium has computer usable instructions embodied thereon, the computer usable instructions configured to cause a computer device to perform the steps of receiving an intermediate program code prior to execution of the intermediate program code; recognizing data storage commands within the intermediate program code; modifying the intermediate program code such that, during execution of the intermediate program code, the data is encrypted before it is stored; recognizing data retrieval commands within the intermediate program code; modifying the intermediate program code such that, during execution of the intermediate program code, the data is decrypted after it is retrieved; and providing the modified intermediate program code for execution.

Abstract: A method of monitoring battery capacity comprises determining a starting capacity of a battery; determining an activity coefficient for a device connected to the battery; determining a voltage and current profile for the battery using the starting capacity; determining a voltage and current operating point for the device using the activity value for the device; and determining an updated capacity of the battery using the voltage and current profile for the battery and the voltage and current operating point for the device.