Abstract: An object of this invention is to provide a method, etc., for efficiently proliferating a pluripotent epithelial somatic stem cell. A method for producing an epithelial somatic stem cell comprising Steps (A) and (B) below: (A) expressing a gene of a protein having an activity for causing a cell in G0 phase or G1 phase to enter S phase, in a cell population including an epithelial somatic stem cell; and (B) culturing the cell obtained in Step (A) in the presence of an extracellular growth factor.

Abstract: An object of this invention is to provide a method, etc., for efficiently proliferating a pluripotent epithelial somatic stem cell. A method for producing an epithelial somatic stem cell comprising Steps (A) and (B) below: (A) expressing a gene of a protein having an activity for causing a cell in G0 phase or G1 phase to enter S phase, in a cell population including an epithelial somatic stem cell; and (B) culturing the cell obtained in Step (A) in the presence of an extracellular growth factor.

Abstract: Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g., of formula (I, Ia or II) as defined herein, having useful properties in the prevention of Hepatitis C infections.

Abstract: The present invention provides (i) a method for proliferating a hepatitis virus, the method including the steps of: infecting, with the hepatitis virus, cells packed into a lumen of a hollow fiber made of a permeabilized membrane; and culturing the cells or (ii) a method for proliferating a hepatitis virus, the method including the steps of: infecting cells with the hepatitis virus; packing the cells into a lumen of a hollow fiber made of a permeabilized membrane; and culturing the cells. This provides an experimental system for infecting in vitro culture cells with a hepatitis virus such as HBV or HCV and then proliferating the hepatitis virus.

Abstract: Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g. of formula (I, Ia or II) as defined herein, having useful properties in the prevention or treatment of Hepatitis C infections.

Abstract: A navigation apparatus is provided with: a first storing device for storing original data for a navigation based on a predetermined format and including map data, in such a manner that an empty area exists on the predetermined format in each processing unit for a predetermined kind of navigation processing; a second storing device for storing difference update data representing a data portion for the navigation that is updated with respect to the original data as a standard; and a re-writing device for generating updated data based on the format and including the original data and merge data, by re-writing the merge data at least partially into the empty area corresponding to the merge data. The merge data defines a relationship of the difference update data with respect to the original data. The navigation apparatus is also provided with a processing device performing the navigation processing on the basis of the original data and the difference update data.

Abstract: The navigation apparatus comprises: a GPS receiving unit, a sensor unit, a DVD disc drive that reads data from a DVD disc on which data such as map data are pre-recorded, a map-data-storage unit that acquires the map data in advance from the DVD disc with perform route guidance and stores it, and a system-control unit that controls the entire system, and that performs route guidance for an automobile based on the map data stored in the map-data-storage unit.

Abstract: A navigation apparatus is provided with: a first storing device for storing original data for a navigation based on a predetermined format and including map data, in such a manner that an empty area exists on the predetermined format in each processing unit for a predetermined kind of navigation processing; a second storing device for storing difference update data representing a data portion for the navigation that is updated with respect to the original data as a standard; and a re-writing device for generating updated data based on the format and including the original data and merge data, by re-writing the merge data at least partially into the empty area corresponding to the merge data. The merge data defines a relationship of the difference update data with respect to the original data. The navigation apparatus is also provided with a processing device performing the navigation processing on the basis of the original data and the difference update data.

Abstract: An apparatus generates difference update data for navigation with respect to a plurality of road data for the navigation. Each of the plurality of road data indicates at least one of an existing road and a junction thereof in a preset road network. The difference update data includes one road data for the navigation. The one road data indicates at least one of a new road and a junction thereof and is updated versus the plurality of road data as a standard.

Abstract: A navigation apparatus which can improve convenience of navigation by starting assisting of the movement without delay by inferring a predetermined route. This navigation apparatus includes a system controlling unit for setting a predetermined route which a vehicle travels, for inferring whether or not the vehicle deviates from a predetermined route and continues during travel of the vehicle along a predetermined route, when it is inferred that the vehicle deviates from the predetermined route, which then begins to set an inferred predetermined route where the vehicle should travel after deviating from the predetermined route.

Abstract: An on-vehicle navigation system having a route searching function for automatically selecting a guiding route to a destination in consideration of run experiences of the user. Run experience data indicative of the run experience is formed every road unit which the vehicle has run and is stored, a plurality of traveling routes which a vehicle can run between a start point and the destination are searched for and weights of the road units in the traveling route and the corresponding run experience data is obtained from memory for each of the plurality of traveling routes in the route searching operation, the weight of each road unit in the traveling route is corrected by the corresponding run experience data for each of the plurality of traveling routes, a sum value of the corrected weights corresponding to the road units in the traveling route is calculated for each of the plurality of traveling routes, and a traveling route of which sum value is the minimum is selected from the plurality of traveling routes.

Abstract: According to the present invention, there is provided a navigation apparatus and so forth which can improve its convenience as a navigation apparatus by starting assisting of the movement without delay by inferring the predetermined route. This navigation apparatus includes a system controlling unit 16 for setting a predetermined route which a vehicle travels, for inferring whether or not the vehicle deviates from the predetermined route and continues traveling during traveling of the vehicle along the predetermined route, when it is inferred that the vehicle deviates from the predetermined route, for starting to set the inferred predetermined route where the vehicle travels after deviating from the predetermined route.

Abstract: In a map information display device, the map data extracting unit extracts character data corresponding to characters from map data corresponding to the map, and the map data converting unit converts the map data including no character data to a bird's-eye-view map data. The character data converting unit selects designated character data from the extracted character data and converts the character data other than the designated character data to bird's-eye-view character data. Then, the combining unit combines the bird's-eye-view character data, the bird's-eye-view map data and the designated character data to produce combined bird's-eye-view data. Then, the display unit displays the map of bird's-eye-view using the combined bird's-eye-view data.

Abstract: In a map information display device, the map data extracting unit extracts character data corresponding to characters from map data corresponding to the map, and the map data converting unit converts the map data including no character data to a bird's-eye-view map data. The character data converting unit selects designated character data from the extracted character data and converts the character data other than the designated character data to bird's-eye-view character data. Then, the combining unit combines the bird's-eye-view character data, the bird's-eye-view map data and the designated character data to produce combined bird's-eye-view data. Then, the display unit displays the map of bird's-eye-view using the combined bird's-eye-view data.

Abstract: A navigation apparatus displays a map so as to support a travel of a movable body.

Abstract: An automatic transmission including at least one rotary member; a rotary member enclosure enclosing the rotary member; and an oil reservoir arranged below the rotary member enclosure for collecting and reserving the oil. An oil separator is located facing the outer circumference of the rotary member for separating the oil adhering to the rotary member. Because the amount of oil left on the surface of the rotary member is reduced, the amount of oil recovered in the oil reservoir is accordingly increased and the level of the oil surface in the oil reservoir is prevented from falling.

Abstract: An oil seal member is compressed between a connecting pipe for supplying oil to an oil chamber of a hydraulic servo and the cylinder drum of the hydraulic servo. The cylinder drum has an interior oil chamber and turns through a predetermined angle upon operation of a frictional engagement element by the hydraulic servo. The end of the seal member pressed against the cylindrical drum surrounds an oil hole 73 formed in the cylindrical drum, and oil pressure is supplied to the oil chamber through an oil passage in which the seal member is mounted and through the oil hole. A recess is formed in the outer surface of the cylindrical drum around the oil hole and the end of the seal member is received in the recess. When the cylindrical member turns within the predetermined angular range, the end of the seal member is protected by the recess. As a result, the end of the seal member is not damaged and the integrity of the seal is protected.

Abstract: A control system for an automatic transmission, in which a first frictional engagement element and a second frictional engagement element are released according to a shift from a running range to a non-running range. The shift from the running range to the non-running range is detected, and the reduction in the oil pressure of the second frictional engagement element is controlled on the basis of the reduction in the oil pressure of the first frictional engagement element when the shift from the running range to the non-running range is detected.

Abstract: An on-vehicle navigation system having a route searching function for automatically selecting a guiding route to a destination in consideration of run experiences of the user. Run experience data indicative of the run experience is formed every road unit which the vehicle has run and is stored, a plurality of traveling routes which a vehicle can run between a start point and the destination are searched for and weights of the road units in the traveling route and the corresponding run experience data is obtained from memory for each of the plurality of traveling routes in the route searching operation, the weight of each road unit in the traveling route is corrected by the corresponding run experience data for each of the plurality of traveling routes, a sum value of the corrected weights corresponding to the road units in the traveling route is calculated for each of the plurality of traveling routes, and a traveling route of which sum value is the minimum is selected from the plurality of traveling routes.

Abstract: An oil temperature responsive hydraulic control system for an automatic transmission includes a hydraulic servo for applying/releasing a frictional engagement element; a pressure regulator valve for regulating oil pressure fed to the hydraulic servo; and a signal pressure oil passage for applying a pressure regulating signal pressure to the pressure regulator valve. A control valve is arranged in the signal pressure oil passage for changing the effective diameter of the signal pressure oil passage responsive to change in oil temperature.