Abstract: The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.

Abstract: The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.

Abstract: Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely and conveniently examined. Namely, theses preparations are useful in objectively diagnosing the gastric motor function, as well as in evaluating and judging the drug effect or therapeutic effect of a drug concerning the gastric motor function on individual patients.

Abstract: The present invention provides a preparation for easily and non-invasively measuring gastric pH, for example, a preparation for measuring gastric pH using the expired air, and a method for measuring gastric pH using the preparation. The preparation of the present invention can be produced by covering a composition containing a compound labeled with an isotope (13C, 14C, 15N, or 18O), with a pH-dependent soluble base.

Abstract: The present invention provide a method for measuring and assessing the capacity in an individual subject to metabolize a variety of fluorouracil drugs, such as 5-fluorouracil, which are degraded in the pyrimidine metabolic pathway, and a preparation useful for the measurement and assessment. The present invention can be carried out by: administering a preparation for determining pyrimidine metabolic capacity comprising as an active ingredient a pyrimidine compound or pyrimidine metabolic compound that acts as a substrate for a pyrimidine metabolizing enzyme, in which at least one of the carbon, oxygen, and nitrogen atoms is labeled with an isotope; and assessing in vivo pyrimidine metabolic capacity based on the behavior of an excreted metabolite.

Abstract: The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine metabolizing activity, of an individual subject; and a preparation useful for the assessment. The present invention can be carried out by: administering a preparation comprising as an active ingredient a pyrimidine compound or its metabolite which acts as a substrate for a pyrimidine metabolizing enzyme, in which compound or metabolite at least one of C, O and N is labeled with an isotope; and assessing in vivo pyrimidine metabolizing activity based on the amount of excreted metabolite.

Abstract: A back electrode (6), linear hot cathodes (7) as electron beam sources, and an electrode unit (8) are placed on and fixed to a rear case (4). On the other hand, wire electrodes (9) fixed to a grid frame (10) are positioned relative to stripes of a phosphor screen (2) and are then placed on and fixed to a supporting frame (11) placed in a front case (3) using stud pins (21). According to such a configuration, when the front case and the rear case are bonded and are thus fixed, the position shift between the phosphor screen (2) and the wire electrodes (9) can be suppressed within a tolerance. As a result, a flat-type display apparatus that can display excellent images can be provided.

Abstract: A method of fabricating an electrode unit for use in a flat type image display apparatus, wherein the flat type image display apparatus includes a plurality of flat sheet-shaped electrodes, comprises the steps of mounting in position a first electrode on a second electrode via an insulative bonding material, temporarily fixing the first electrode to the second electrode via a pair of opposing temporary fixing parts formed in each of the first and second electrodes, permanently fixing the first electrode to the second electrode via the insulative bonding material, and removing the pair of temporary fixing parts. The step of temporarily fixing is performed using a temporary fixing spacer disposed between the temporary fixing parts.

Abstract: A novel electrode unit includes a plurality of linear cathodes and a plurality of flat-shaped electrodes. Each of the electrodes has a plurality of identification holes. The relative positional relationship of the identification holes is uniform with regard to each of the electrodes. However, the positions of the identification holes are shifted from those of adjacent electrodes by a predetermined interval so that a line connecting centers of the ID holes is parallel or perpendicular to a longitudinal direction of the linear cathodes when the electrodes are piled up and evenly aligned. The identification holes allow the electrodes to be accurately positioned with respect to each other when assembling the electrodes into the electrode unit. Each of the electrodes also includes a temporary fixing part at an area indented from an outer circumference of the electrode. During assembly of an electrode unit, the temporary fixing part is fixed to a temporary fixing part of an adjacent electrode via a spacer.

Abstract: A fixed construction for plate electrodes in a flat display unit, wherein holes provided along a common axis through a plurality of plate electrodes have a diameter smaller than that of a tapered insulating pin to be inserted therein, and the peripheral portions of the holes are formed in a thin or tapered construction, thereby supporting and fixing the plate electrodes in position without interposing a spacer and without causing deformation to the areas around the peripheries of the holes formed in the plate electrodes when insulating pins are fitted.