Abstract: The object of the present invention is to provide a novel dehydrogenase having a property which is different from that of known dehydrogenases. The present invention provides a dehydrogenase having the following physicochemical properties: (1) effect: to produce N-alkyl-L-alanine from pyruvic acid and alkylamine or dialkylamine using NADPH and/or NADH as coenzyme; (2) substrate specificity: to show activity to alkylamine or dialkylamine but not to ammonium; (3) optimal pH when using phenylpyruvic acid and methylamine as substrates is around 10; and (4) when treated at 30° C. for 30 minutes, the enzyme is stable at around pH 5 to 10.5.

Abstract: The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a ?-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group.

Abstract: According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase according to the present invention is excellent in activity and stereoselectivity. Thus, according to the present invention, there is provided a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc.

Abstract: A container for an analyzer capable of preventing a sample or a reagent from contamination is obtained. This container for an analyzer comprises a container body, having an opening, storing a sample therein, a lid member, coupled to the container body, having a closing part closing the opening of the container body, and a closing state holding part holding the closing part in a state closing the opening.

Abstract: A sample analyzer allowing miniaturization and sufficiently prompt analysis is obtained. This sample analyzer comprises a dispensing part rendered movable above a sample container set part, a reagent container set part and a detection part for sucking a sample and a reagent from the sample container and the reagent container respectively while discharging the sucked sample and the sucked reagent into the detection container. The detection part is arranged oppositely to the sample container set part and the reagent container set part.

Abstract: The present invention provides a transparent latch circuit capable of performing a scan test in general scan design (GSD). In the transparent latch circuit a test signal is at a Low level during normal operation. Since a latch stop circuit outputs a High-level latch stop signal, a slave latch circuit has a received signal pass through it directly and a master latch circuit operates as a latch circuit in response to a signal output from an inverter. On the other hand, a test signal is at a High level during scan test. At this point, the latch stop circuit outputs a signal complementary to the signal output from the inverter. Therefore, the master latch circuit and the slave latch circuit operate as latch circuits responding to signals complementary to each other. Thereby, the entire transparent latch circuit operates as a flip-flop circuit.

Abstract: A method of detecting a gene as an amplified product includes subjecting a solution containing the gene to a gene amplification reaction at a predetermined reaction temperature in the presence of a surfactant having a higher clouding point than the predetermined reaction temperature and detecting the gene as an amplified product, and a reagent kit for the method of detecting the gene as the amplified product utilizing the gene amplification includes a primer necessary for amplifying the gene, an enzyme for amplifying the gene, and a surfactant having a clouding point higher than the predetermined reaction temperature, wherein the primer is packed separately from the enzyme, and the surfactant is packed with the primer or the enzyme, or separately.

Abstract: A multiprocessor system includes a plurality of processor modules having a detector for detecting accesses by respective tasks to data shared among cache memories in the processor modules. Also included is a storage device for storing an address of the shared data, identification information of the tasks that accessed the shared data, and the number of accesses to the same shared data by the same task.

Abstract: L-Ribose is produced by the steps of producing ribitol from a saccharide raw material by using a microorganism having an ability to produce ribitol from a saccharide raw material, producing L-ribulose from the ribitol by using a microorganism having an ability to produce L-ribulose from ribitol, and producing L-ribose from the L-ribulose by using a microorganism having an ability to produce L-ribose from L-ribulose.

Abstract: A method for accessing to a DRAM and a DRAM controller of the same, which enables a high speed DRAM access and a DRAM controller. Provided is an accessing method to a DRAM, which comprises the steps of detecting an access type to the DRAM; and changing an access mode depending on the detected access type. Furthermore, provided is an accessing method to a DRAM which comprises the steps of detecting whether a currently accessed row address and an address lastly accessed; and changing an access mode depending on an existence of the coincidence of the detected row addresses.

Abstract: A control rod for a nuclear reactor is composed of a center structural member, a plurality of wings each composed of a sheath member of long plate structure having a U-shaped cross section and secured to the center structural member, a front end structural member secured to a front end side of the wing in a wing inserting direction in a reactor core, a terminal end structural member secured to a terminal end side of the wing, a plurality of integral type neutron absorbing elements each having a plate structure accommodated in each of the sheaths in a row in a longitudinal direction thereof and each being formed in plate shape by integrating one or more neutron absorbing plates, and a plurality of load supporting members for supporting weights of the integral type neutron absorbing elements.

Abstract: There is provided a reactor control rod which is capable of suppressing an excessive frictional force acting on passive state oxide films formed on the surfaces of neutron absorber elements, and also reducing the possibility to cause electrochemical problems, and a method of manufacturing the same. The reactor control rod comprises a wing having a sheath which has a substantially U-shaped cross-section. A top end structure is secured to a longitudinal top end of the sheath. A bottom end structure is secured to a longitudinal bottom end of the sheath. An opening portion of the sheath is secured to a central structure. A neutron absorber element is made of neutron absorbing material. The neutron absorber element is charged in the sheath. A supporting rod through hole is formed in the neutron absorber element, so as to penetrate the neutron absorber element. A supporting rod fitting hole is formed in the sheath. A load supporting rod is inserted into the supporting rod through hole.

Abstract: A control rod for a nuclear reactor is composed of a center structural member, a plurality of wings each composed of a sheath member of long plate structure having a U-shaped cross section and secured to the center structural member, a front end structural member secured to a front end side of the wing in a wing inserting direction in a reactor core, a terminal end structural member secured to a terminal end side of the wing, a plurality of integral type neutron absorbing elements each having a plate structure accommodated in each of the sheaths in a row in a longitudinal direction thereof and each being formed in plate shape by integrating one or more neutron absorbing plates, and a plurality of load supporting members for supporting weights of the integral type neutron absorbing elements.

Abstract: Microbial cells and/or a preparation thereof of a microorganism is allowed to act on ester of .gamma.-halogenated-acetoacetic acid, and its carbonyl group at .beta.-position is stereospecifically reduced to produce ester of (S)-.gamma.-halogenated-.beta.-hydroxybutyric acid in a short period of time at a highly accumulated degree and at a high yield, the microorganism being selected from the group consisting of those belonging to the genera Phoma, Nectria, Pseudonectria, Spondylocladium, Melanospora, Metarhizium, Gliocladium, Pestalotia, Pestalotiopsis, Curvularia, Hormonema, Sydowia, Sarcinomyces, Dothiora, Xanthothecium, Dothidea, Pringsheimia, and Selenophoma.

Abstract: The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as intermediates thereof; and a simple process for the preparation of an optically active substituted styrene oxide or 2-amino-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or intermediates thereof. A 2-halo-1-(substituted phenyl)ethanol represented by the following general formula (I) is allowed to contact, in the presence of a carboxylic anhydride, with an enzyme stereoselectively catalyzing ester interchange to produce an optically active 2-halo-1-(substituted phenyl)ethanol: ##STR1## (wherein X represents a chlorine atom or a bromine atom, and R.sup.1, R.sup.2 and R.sup.3 may be the same or different and each represent a hydrogen atom, a halogen atom, a C.sub.1-5 alkyl group, a C.sub.1-5 haloalkyl group, a C.sub.

Abstract: A process tolerant delay circuit includes a plurality of inverters that receive an input signal and provide an output signal related to the input signal but including a propagation delay of the plurality of inverters. At least one inverter comprises FETs of minimum channel lengths dependent upon a fabrication process by which the circuit was made. Accordingly, the plurality of inverters have a propagation delay dependent upon the fabrication process. A delay compensation device receives the output signal of the inverters and provides a compensated output signal related to the received signal but including a variable delay established in accordance with a control signal. A process sense stack provides the control signal only during a transition of the input signal, and with a value dependent upon a channel length of a FET device thereof.

Abstract: A process tolerant delay circuit includes a plurality of inverters that receive an input signal and provide an output signal related to the input signal but including a propagation delay of the plurality of inverters. At least one inverter comprises FETs of minimum channel lengths dependent upon a fabrication process by which the circuit was made. Accordingly, the plurality of inverters have a propagation delay dependent upon the fabrication process. A delay compensation device receives the output signal of the inverters and provides a compensated output signal related to the received signal but including a variable delay established in accordance with a control signal. A process sense stack provides the control signal only during a transition of the input signal, and with a value dependent upon a channel length of a FET device thereof.

Abstract: A method for producing a 3-hydroxy nitrogen-containing six-membered cyclic compound is provided. Namely, microbial cells of a microorganism and/or a preparation obtained from the microbial cells is allowed to act on a nicotinic acid derivative or a 2-pyrazinecarboxylic acid derivative represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, representing hydrogen atom, halogen atom, hydroxyl group, amino group, carboxyl group, cyano group, oxime group, or alkyl group having a number of carbon atom or atoms of 1 to 5 respectively, and A represents carbon atom or nitrogen atom, the microbial cells and/or the preparation obtained from the microbial cells having an ability to perform hydroxylation of the nicotinic acid derivative or the 2-pyrazinecarboxylic acid derivative accompanied by decarboxylation of carboxyl group.

Abstract: Microbial cells and/or a preparation therefrom of a microorganism is allowed to act on an ester of .gamma.-substituted-acetoacetic acid, and a carbonyl group at its .beta.-position is stereospecifically reduced, wherein the microorganism is selected from the group consisting of those belonging to the genera Yarrowia, Filobasidium, Metschnikowia, Galactomyces, Ambrosiozyma, Trichosporonoides, Aureobasidium, Phaeococcomyces, Rosulomyces, Dothichiza, Emericellopsis, Calonectria, Colletotrichum, and Ceratocystis, preferably, the microorganism is microorganism belonging to the genus Aureobasidium. Thus an optically active ester of .gamma.-substituted-.beta.-hydroxybutyric acid having a high optical purity is produced in a short period of time at a high accumulated concentration and a high yield.

Abstract: A process tolerant delay circuit includes a plurality of inverters that receive an input signal and provide an output signal related to the input signal but including a propagation delay of the plurality of inverters. At least one inverter comprises FETs of minimum channel lengths dependent upon a fabrication process by which the circuit was made. Accordingly, the plurality of inverters have a propagation delay dependent upon the fabrication process. A delay compensation device receives the output signal of the inverters and provides a compensated output signal related to the received signal but including a variable delay established in accordance with a control signal. A process sense stack provides the control signal only during a transition of the input signal, and with a value dependent upon a channel length of a FET device thereof.