Patents by Inventor Malcolm Walden

Malcolm Walden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Buprenorphine-wafer for drug substitution therapy
    Patent number: 9370512
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: June 21, 2016
    Assignee: PURDUE PHARMA L.P.
    Inventors: Alexander Oksche, William Heath, Timothy Holden, Derek A. Prater, Richard S. Sackler, Malcolm Walden
  • IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE
    Publication number: 20160136156
    Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.
    Type: Application
    Filed: January 21, 2016
    Publication date: May 19, 2016
    Inventors: Helen Kathleen Danagher, Geoffrey Gerard Hayes, Gerhard Josef Heun, Hassan Mohammad, Malcolm Walden, Jonathon Oliver Whitehouse
  • Immediate release pharmaceutical compositions comprising oxycodone and naloxone
    Patent number: 9271940
    Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: March 1, 2016
    Assignee: Purdue Pharma L.P.
    Inventors: Helen Kathleen Danagher, Geoffrey Gerard Hayes, Gerhard Josef Heun, Hassan Mohammad, Malcolm Walden, Jonathon Oliver Whitehouse
  • Multiparticulates
    Patent number: 9259872
    Abstract: Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: February 16, 2016
    Assignee: EURO-CELTIQUE S.A.
    Inventors: Geoffrey Gerard Hayes, Vincenzo Martinelli, Hassan Mohammad, Harjit Tamber, Malcolm Walden, Steve Whitelock
  • Buprenorphine-Wafer for Drug Substitution Therapy
    Publication number: 20150328143
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Application
    Filed: July 15, 2015
    Publication date: November 19, 2015
    Inventors: Alexander OKSCHE, William HEATH, Timothy HOLDEN, Derek A. PRATER, Richard S. SACKLER, Malcolm WALDEN
  • Buprenorphine-wafer for drug substitution therapy
    Patent number: 9101625
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: August 11, 2015
    Assignee: PURDUE PHARMA L.P.
    Inventors: Alexander Oksche, William Heath, Timothy Holden, Derek A. Prater, Richard S. Sackler, Malcolm Walden
  • Particulates
    Publication number: 20150148366
    Abstract: A neutral poly(ethyl acrylate, methyl methacrylate) copolymer is employed as a carrier in the manufacture of pharmaceutical formulations containing an active ingredient. The formulations are preferably made by melt extrusion, and can have rubbery characteristics and can exhibit tamper resistance.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 28, 2015
    Inventors: Geoffrey Gerard Hayes, Hassan Mohammad, Harjit Tamber, Malcolm Walden, Steve Whitelock, Helen Kathleen Danagher, Derek Allan Prater
  • Pharmaceutical spheroids
    Patent number: 9034373
    Abstract: According to the invention glyceryl monostearate and a polymeric binder are employed as a spheronising aid in the manufacture of pharmaceutical spheroids containing no or substantially no microcrystalline cellulose. The spheroids can contain one or more therapeutically active agent which undergoes no or substantially no degradation when stored under accelerated temperature and humidity conditions. A coating may be applied to the spheroids; when present, the coating is preferably a controlled release coating.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: May 19, 2015
    Assignee: EURO-CELTIQUE S.A.
    Inventors: Malcolm Walden, Hassan Mohammad, Geoffrey Gerard Hayes, Helen Kathleen Danagher, Jonathon Oliver Whitehouse
  • Buprenorphine-Wafer for Drug Substitution Therapy
    Publication number: 20150025102
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 22, 2015
    Inventors: Alexander OKSCHE, William HEATH, Timothy HOLDEN, Derek A. PRATER, Richard S. SACKLER, Malcolm WALDEN
  • Particulates
    Patent number: 8920836
    Abstract: A neutral poly(ethyl acrylate, methyl methacrylate) copolymer is employed as a carrier in the manufacture of pharmaceutical formulations containing an active ingredient. The formulations are preferably made by melt extrusion, and can have rubbery characteristics and can exhibit tamper resistance.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: December 30, 2014
    Assignee: Euro-Celtique S.A.
    Inventors: Geoffrey Gerard Hayes, Hassan Mohammad, Harjit Tamber, Malcolm Walden, Steve Whitelock, Helen Kathleen Danagher, Derek Allan Prater
  • COMBINATION OF ACTIVE LOADED GRANULES WITH ADDITIONAL ACTIVES
    Publication number: 20130197021
    Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human being
    Type: Application
    Filed: May 10, 2011
    Publication date: August 1, 2013
    Applicant: Euro-Celtique S.A.
    Inventors: Hassan Mohammad, Malcolm Walden, Geoffrey Gerard Hayes, Harjit Tamber
  • PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROMORPHONE AND NALOXONE
    Publication number: 20130178492
    Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.
    Type: Application
    Filed: May 10, 2011
    Publication date: July 11, 2013
    Applicant: Euro-Celtique S.A.
    Inventors: Helen Kathleen Danagher, Hassan Mohammad, Malcolm Walden, Geoffrey Gerard Hayes, Jonathon Oliver Whitehouse, Thinnayam Naganathan Krishnamurthy, Ricardo Alberto Vargas Rincon
  • MANUFACTURING OF ACTIVE-FREE GRANULES AND TABLETS COMPRISING THE SAME
    Publication number: 20130165467
    Abstract: The present invention relates to prolonged release pharmaceutical dosage forms, the manufacture thereof as well as their use for administration to human beings.
    Type: Application
    Filed: May 10, 2011
    Publication date: June 27, 2013
    Applicant: Euroceltique S.A.
    Inventors: Geoffrey Gerard Hayes, Hassan Mohammad, Harjit Tamber, Malcolm Walden
  • Opioid Composition for Treating Skin Lesions
    Publication number: 20120093929
    Abstract: The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix.
    Type: Application
    Filed: May 5, 2009
    Publication date: April 19, 2012
    Applicant: Euro-Celtique S.A.
    Inventors: Alexander Oksche, Kevin J. Smith, Derek Prater, Malcolm Walden, Will Heath, Bernard Kennedy, Vanessa Addison, Hassan Mohammad
  • IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE
    Publication number: 20120088786
    Abstract: The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and naloxone or their pharmaceutically acceptable salts.
    Type: Application
    Filed: March 10, 2010
    Publication date: April 12, 2012
    Inventors: Helen Kathleen Dadagher, Geoffrey Gerard Hayes, Gerhard Josef Heun, Hassan Mohammad, Malcolm Walden, Jonathon Oliver Whitehouse
  • Pharmaceutical composition
    Patent number: 7704948
    Abstract: A stool softener and enteric coated bisacodyl form of a pharmaceutical composition.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: April 27, 2010
    Assignee: Euro-Celtique S.A.
    Inventors: Derek Allan Prater, Hassan Mohammed, Malcolm Walden, Geoff Hayes, Harjit Tamber
  • Buprenorphine-Wafer for Drug Substitution Therapy
    Publication number: 20100087470
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Application
    Filed: August 29, 2007
    Publication date: April 8, 2010
    Applicant: EURO-CELTIQUE S.A.
    Inventors: Alexander Oksche, William Heath, Timothy Holden, Derek A. Prater, Richard S. Sackler, Malcolm Walden
  • PHARMACEUTICAL SPHEROIDS
    Publication number: 20100047337
    Abstract: According to the invention glyceryl monostearate and a polymeric binder are employed as a spheronising aid in the manufacture of pharmaceutical spheroids containing no or substantially no microcrystalline cellulose. The spheroids can contain one or more therapeutically active agent which undergoes no or substantially no degradation when stored under accelerated temperature and humidity conditions. A coating may be applied to the spheroids; when present, the coating is preferably a controlled release coating.
    Type: Application
    Filed: March 16, 2007
    Publication date: February 25, 2010
    Applicant: EURO-CELTIQUE S.A.
    Inventors: Malcolm Walden, Hassan Mohammad, Geoffrey Gerard Hayes, Helen Kathleen Danagher, Jonathan Oliver Whitehouse
  • EXTRUSION
    Publication number: 20090029170
    Abstract: The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
    Type: Application
    Filed: September 30, 2008
    Publication date: January 29, 2009
    Inventors: Geoffrey Gerard Hayes, Vincenzo Martinelli, Hassan Mohammad, Derek Allan Prater, Harjit Tamber, Malcolm Walden, Steve Whitelock
  • Multiparticulates
    Publication number: 20080260815
    Abstract: Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticising excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
    Type: Application
    Filed: August 31, 2005
    Publication date: October 23, 2008
    Inventors: Geoffrey Gerard Hayes, Vincenzo Martinelli, Hassan Mohammad, Harjit Tamber, Malcolm Walden, Steve Whitelock