Patents by Inventor Mallikarjun Sundaram

Mallikarjun Sundaram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190353640
    Abstract: The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said culturing provides human ligands and tumor tissue micro-environment to mimic physiologically relevant signalling systems. The present disclosure further relates to the development of a Clinical Response Predictor and its application in the prognostic field (selection of treatment option for the patient) and translational biology field (development of anticancer drugs). The disclosure further relates to a method of predicting clinical response of a tumor patient to drug(s). The disclosure further relates to a method for screening tumor cells for the presence of specific markers for determining the viability of said cells for indication of tumor status.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 21, 2019
    Inventors: Mallikarjun SUNDARAM, Pradip MAJUMDER, Biswanath MAJUMDER, Misti JAIN, Saravanan THIAGARAJAN, Dency PINTO, Padhma RADHAKRISHNAN
  • Publication number: 20190346428
    Abstract: The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said culturing provides human ligands and tumor tissue micro-environment to mimic physiologically relevant signalling systems. The present disclosure further relates to the development of a Clinical Response Predictor and its application in the prognostic field (selection of treatment option for the patient) and translational biology field (development of anticancer drugs). The disclosure further relates to a method of predicting clinical response of a tumor patient to drug(s). The disclosure further relates to a method for screening tumor cells for the presence of specific markers for determining the viability of said cells for indication of tumor status.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 14, 2019
    Inventors: Mallikarjun SUNDARAM, Pradip MAJUMDER, Biswanath MAJUMDER, Misti JAIN, Saravanan THIAGARAJAN, Dency PINTO, Padhma RADHAKRISHNAN
  • Publication number: 20190170730
    Abstract: The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said culturing provides human ligands and tumor tissue micro-environment to mimic physiologically relevant signalling systems. The present disclosure further relates to the development of a Clinical Response Predictor and its application in the prognostic field (selection of treatment option for the patient) and translational biology field (development of anticancer drugs). The disclosure further relates to a method of predicting clinical response of a tumor patient to drug(s). The disclosure further relates to a method for screening tumor cells for the presence of specific markers for determining the viability of said cells for indication of tumor status.
    Type: Application
    Filed: October 26, 2018
    Publication date: June 6, 2019
    Inventors: Mallikarjun SUNDARAM, Pradip MAJUMDER, Biswanath MAJUMDER, Misti JAIN, Saravanan THIAGARAJAN, Dency PINTO, Padhma RADHAKRISHNAN
  • Publication number: 20160243153
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 9358252
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: June 7, 2016
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 9351992
    Abstract: Preparations of polysaccharides lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: May 31, 2016
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Publication number: 20160060366
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: November 9, 2015
    Publication date: March 3, 2016
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 9212233
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: December 15, 2015
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Publication number: 20140228246
    Abstract: The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said culturing provides human ligands and tumor tissue micro-environment to mimic physiologically relevant signalling systems. The present disclosure further relates to the development of a Clinical Response Predictor and its application in the prognostic field (selection of treatment option for the patient) and translational biology field (development of anticancer drugs). The disclosure further relates to a method of predicting clinical response of a tumor patient to drug(s). The disclosure further relates to a method for screening tumor cells for the presence of specific markers for determining the viability of said cells for indication of tumor status.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 14, 2014
    Inventors: Mallikarjun Sundaram, Pradip Majumder, Biswanath Majumder, Misti Jain, Saravanan Thiagarajan, Dency Pinto, Padhma Radhakrishnan
  • Patent number: 8715953
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 6, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ganesh Kaundinya, Zachary Shriver, Mallikarjun Sundaram, Yi-wei Qi, Ram Sasisekharan
  • Publication number: 20140057358
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: November 1, 2013
    Publication date: February 27, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Ganesh Kaundinya, Zachary Shriver, Mallikarjun Sundaram, Yi-wei Qi, Ram Sasisekharan
  • Publication number: 20140031315
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 30, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Publication number: 20140024602
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 23, 2014
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 8609632
    Abstract: Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: December 17, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Pat Oliver-Shaffer, Yiming Yao, Zainab Sirajbhai Mamuwala, Ian David Fier, Yiwei Qi, Ishan Capila, Nur Sibel Gunay, Daniela Beccati, Cuihua Liu, Corinne Bauer, Ying Li
  • Patent number: 8592393
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: November 26, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 8569262
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: October 29, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Patent number: 8512969
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: August 20, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Publication number: 20130065852
    Abstract: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 14, 2013
    Inventors: Ganesh Venkataraman, Zachary Shriver, Mallikarjun Sundaram, Yi-wei Qi, Ram Sasisekharan
  • Publication number: 20130017565
    Abstract: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
    Type: Application
    Filed: May 7, 2012
    Publication date: January 17, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi
  • Patent number: 8173384
    Abstract: The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: May 8, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Zachary Shriver, Dongfang Liu, Mallikarjun Sundaram, Yiwei Qi