Abstract: Provided is a method and a medicament for treating amyotrophic lateral sclerosis (ALS) in a subject in need thereof, comprising administering to the subject an effective amount of one or more active agents selected from the group consisting of a retinoic acid receptor alpha (RAR?) agonist, a voltage-gated potassium channel (KCNB2) inhibitor, an adrenergic receptor ?2B (ADRA2B) antagonist, a DNA methyltransferase 3 alpha (DNMT3A) antagonist, an insulin like growth factor 1 receptor (IGF1R) inhibitor, a mitogen-activated protein kinase 1 (MAPK1) inhibitor, a nitric oxide synthase 1 (NOS1) inhibitor, a glucocorticoid receptors (NR3C1) antagonist, and a peptidylprolyl Isomerase A (PPIA) antagonist.

Abstract: The disclosure relates to a content processing method and apparatus, a device, and a storage medium. The method includes: showing a target content page to display a multimedia content; determining a content consumption intention on the multimedia content based on browsing information corresponding to the target content page; determining target summary information that adapted to the content consumption intention, where the target summary information is generated at least based on the multimedia content; in response to the content consumption intention being a shallow consumption intention, the target summary information is first summary information; and in response to the content consumption intention being a deep consumption intention, the target summary information is second summary information with a larger information content; and displaying the target summary information on the target content page.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.

Abstract: The present invention provides engineered clostridial toxins comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pi) of the engineered clostridial toxin to a value that is at least 0.2 pi units higher than the pi of an otherwise identical clostridial toxin lacking said at least one amino acid modification, and wherein said at least one amino acid modification is not located in the clostridial toxin binding domain (Hc domain). Also provided are medical uses of the engineered clostridial toxins.

Abstract: The present invention relates to a method for proteolytically processing a single-chain clostridial neurotoxin into a corresponding di-chain clostridial neurotoxin, the method comprising: providing a single-chain clostridial neurotoxin; and contacting the single-chain clostridial neurotoxin with furin; wherein the single-chain clostridial neurotoxin has an activation loop comprising or consisting of the polypeptide sequence Arg-Xaa-Xaa-Arg; and wherein furin hydrolyses a peptide bond of the activation loop thereby producing a di-chain clostridial neurotoxin. The invention also relates to engineered clostridial neurotoxins and methods for manufacturing the same, as well as related pharmaceutical compositions, nucleotide sequences, and therapeutic and cosmetic uses.

Abstract: A fastener includes a main body having a tubular portion and a split portion that extends from a lower end of the tubular portion, and longitudinally includes a tapered section that tapers in a direction towards the tubular portion. The fastener further includes an expansion sleeve annularly surrounding the split portion, wherein the expansion sleeve longitudinally extends to a lower end of the tapered section.

Abstract: Systems and methods for variant calling in single molecule sequencing from a genomic dataset using a convolutional deep neural network. The method includes: transforming properties of each of the variants into a multi-dimensional tensor; passing the multi-dimensional tensors through a trained convolutional deep neural network to predict categorical output variables, the convolutional deep neural network minimizing a cost function iterated over each variant, the convolutional deep neural network trained using a training genomic dataset including previously identified variants, the convolutional neural network including: a plurality of pooled convolutional layers and at least two fully-connected layers connected sequentially after the last of the pooled convolutional layers, the at least two fully-connected layers comprising a second fully-connected layer connected sequentially after a first fully-connected layer; and outputting the predicted categorical output variables.

Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.

Abstract: Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.

Abstract: The invention provides methods for producing soluble di-chain BoNT/A protein.

Abstract: The present invention relates to chimeric neurotoxins with enhanced properties and their use in therapy.

Abstract: The present invention relates to chimeric neurotoxins with enhanced properties and their use in therapy.

Abstract: Embodiments of the present disclosure discloses a temperature detecting device, a temperature detecting system and a temperature detecting method. The temperature detecting device includes: a bearing support, a first end of the bearing support being fixed; a temperature detector, provided on a second end of the bearing support; a moving component, configured to be connected with the bearing support, wherein the second end of the bearing support is movable with respect to the first end under driving of the moving component.

Abstract: A roller head for a skin treatment device configured to drive the roller head by an electro-mechanical mechanism; a surface of the roller head comprises at least one peak, the at least one peak is arranged so that, when in use, a first surface of the peak contacts with the skin with when the roller head rotated in a clockwise direction and a second surface of the peak contacts with the skin with when the roller head rotated in an anticlockwise direction wherein the first surface differs from the second surface and the first surface is configured to provide a first benefit and the second surface is configured to provide a second benefit.

Abstract: A video processing method, apparatus, and device and a storage medium are provided. The method includes: monitoring an operation indication inputted by a user through a personal homepage on a social platform, the personal homepage being used for displaying personal information of the user; obtaining, when the operation indication is a shooting indication for shooting a personal status video, the personal status video; uploading the personal status video to a back-end server of the social platform; and displaying indication information of the personal status video in a personal-information display region of the personal homepage.

Abstract: The present invention provides engineered clostridial toxins comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pi) of the engineered clostridial toxin to a value that is at least 0.2 pi units higher than the pi of an otherwise identical clostridial toxin lacking said at least one amino acid modification, and wherein said at least one amino acid modification is not located in the clostridial toxin binding domain (Hc domain). Also provided are medical uses of the engineered clostridial toxins.

Abstract: The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking said at least one amino acid modification. Also provided are corresponding uses of the engineered clostridial toxin in therapy.

Abstract: Method for preventing or treating a condition or disease in a subject comprising administering to the subject an engineered clostridial toxin comprising at least one amino acid modification that increases the isoelectric point of the toxin to a value that is at least 0.2 pI units higher than the isoelectric point of an otherwise identical clostridial toxin lacking the modification.

Abstract: A fastener includes a main body having a tubular portion and a split portion that extends from a lower end of the tubular portion, and longitudinally includes a tapered section that tapers in a direction towards the tubular portion. The fastener further includes an expansion sleeve annularly surrounding the split portion, wherein the expansion sleeve longitudinally extends to a lower end of the tapered section.

Abstract: The present invention relates to a method for forming silica nanoparticles in an aqueous medium, the method comprising steps of providing a surfactant solution comprising a cationic surfactant in an aqueous medium; and mixing a silane source with the surfactant solution under pH conditions of about pH 5 to 8 for forming said silica nanoparticles. The present invention also relates to silica suspension comprising a plurality of hexagonally shaped silica platelets, said platelets being substantially monodisperse and having a width dimension from around 50 to 1000 nm, said platelets being suspended in an aqueous medium, wherein said aqueous medium comprises a single type of cationic surfactant. Furthermore, the invention relates to a silica nanoparticle prepared by reacting a silane source with a volumetric excess of a surfactant under pH of about 5 to about 8 in the presence of an aqueous solvent. Also, the present invention relates to a silica platelet obtainable by a method as disclosed herein.